New pH-Sensitive Vesicles. Release Control of Trapped Materials from the Inner Aqueous Phase of Vesicles Made from Triple-Chain Amphiphiles Bearing Two Carboxylate Groups
The pH-induced release of trapped materials from the inner aqueous phase of vesicles made from the synthetic triple-chain amphiphile 1 bearing two carboxyl groups was investigated. While a particular pH-dependence of the release of trapped materials from the inside of vesicles made from distearoylph...
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Veröffentlicht in: | Langmuir 2001-02, Vol.17 (3), p.609-612 |
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creator | Sumida, Yasushi Masuyama, Araki Takasu, Mayuko Kida, Toshiyuki Nakatsuji, Yohji Ikeda, Isao Nojima, Masatomo |
description | The pH-induced release of trapped materials from the inner aqueous phase of vesicles made from the synthetic triple-chain amphiphile 1 bearing two carboxyl groups was investigated. While a particular pH-dependence of the release of trapped materials from the inside of vesicles made from distearoylphosphatidylcholine (DSPC) was not observed, vesicles made from compound 1 showed unique pH-sensitive character toward the pH of the outer bulk phase as follows: it released less than 10% of 5(6)-carboxyfluorescein (CF) as a water-soluble marker at pH 7.5 after 1 year. But the vesicular assemblies were broken below pH 3.5−4.0, resulting in the liberation of the trapped CF into the bulk phase. The latter result is associated with a full-protonation of the carboxylate groups of compound 1. In the case of vesicles made from a mixture of DSPC and compound 1, the addition of cholesterol into the vesicle membranes was effective in providing clear pH-sensitive character for this type of vesicle. The ζ potentials of a series of vesicles containing compound 1 at various pH synchronized well with the pK a1 value of vesicles made from compound 1 and the pH-dependence of the release of trapped CF from these vesicles. |
doi_str_mv | 10.1021/la0008939 |
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While a particular pH-dependence of the release of trapped materials from the inside of vesicles made from distearoylphosphatidylcholine (DSPC) was not observed, vesicles made from compound 1 showed unique pH-sensitive character toward the pH of the outer bulk phase as follows: it released less than 10% of 5(6)-carboxyfluorescein (CF) as a water-soluble marker at pH 7.5 after 1 year. But the vesicular assemblies were broken below pH 3.5−4.0, resulting in the liberation of the trapped CF into the bulk phase. The latter result is associated with a full-protonation of the carboxylate groups of compound 1. In the case of vesicles made from a mixture of DSPC and compound 1, the addition of cholesterol into the vesicle membranes was effective in providing clear pH-sensitive character for this type of vesicle. The ζ potentials of a series of vesicles containing compound 1 at various pH synchronized well with the pK a1 value of vesicles made from compound 1 and the pH-dependence of the release of trapped CF from these vesicles.</description><identifier>ISSN: 0743-7463</identifier><identifier>EISSN: 1520-5827</identifier><identifier>DOI: 10.1021/la0008939</identifier><language>eng</language><publisher>American Chemical Society</publisher><subject>Biological membranes ; Lipids ; pH effects</subject><ispartof>Langmuir, 2001-02, Vol.17 (3), p.609-612</ispartof><rights>Copyright © 2001 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a424t-ff0e89ebccc4da778030177c374ef9e393ba3bb9b3aa7e505a58c0e0340fb0b63</citedby><cites>FETCH-LOGICAL-a424t-ff0e89ebccc4da778030177c374ef9e393ba3bb9b3aa7e505a58c0e0340fb0b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/la0008939$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/la0008939$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,777,781,2752,27057,27905,27906,56719,56769</link.rule.ids></links><search><creatorcontrib>Sumida, Yasushi</creatorcontrib><creatorcontrib>Masuyama, Araki</creatorcontrib><creatorcontrib>Takasu, Mayuko</creatorcontrib><creatorcontrib>Kida, Toshiyuki</creatorcontrib><creatorcontrib>Nakatsuji, Yohji</creatorcontrib><creatorcontrib>Ikeda, Isao</creatorcontrib><creatorcontrib>Nojima, Masatomo</creatorcontrib><title>New pH-Sensitive Vesicles. Release Control of Trapped Materials from the Inner Aqueous Phase of Vesicles Made from Triple-Chain Amphiphiles Bearing Two Carboxylate Groups</title><title>Langmuir</title><addtitle>Langmuir</addtitle><description>The pH-induced release of trapped materials from the inner aqueous phase of vesicles made from the synthetic triple-chain amphiphile 1 bearing two carboxyl groups was investigated. While a particular pH-dependence of the release of trapped materials from the inside of vesicles made from distearoylphosphatidylcholine (DSPC) was not observed, vesicles made from compound 1 showed unique pH-sensitive character toward the pH of the outer bulk phase as follows: it released less than 10% of 5(6)-carboxyfluorescein (CF) as a water-soluble marker at pH 7.5 after 1 year. But the vesicular assemblies were broken below pH 3.5−4.0, resulting in the liberation of the trapped CF into the bulk phase. The latter result is associated with a full-protonation of the carboxylate groups of compound 1. In the case of vesicles made from a mixture of DSPC and compound 1, the addition of cholesterol into the vesicle membranes was effective in providing clear pH-sensitive character for this type of vesicle. The ζ potentials of a series of vesicles containing compound 1 at various pH synchronized well with the pK a1 value of vesicles made from compound 1 and the pH-dependence of the release of trapped CF from these vesicles.</description><subject>Biological membranes</subject><subject>Lipids</subject><subject>pH effects</subject><issn>0743-7463</issn><issn>1520-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNp90cFu1DAQBmALgcRSeuANfAHEIa0T2-v4uER0W6ktK5oCN2uSnbAu3ji1s7R9JZ4Sr0J7QsiWfPlmfo2HkDc5O8pZkR87YIyVmutnZJbLgmWyLNRzMmNK8EyJOX9JXsV4k5DmQs_I70u8o8NpdoV9tKP9hfQrRts6jEf0CzqEiLTy_Ri8o76jdYBhwDW9gBGDBRdpF_yWjhukZ32PgS5ud-h3ka42-8pU8dgulaxx0nWwg8Os2oDt6WI7bGy6e_IRIdj-B63vPK0gNP7-waUgugx-N8TX5EWXEvHw73tArk8-1dVpdv55eVYtzjMQhRizrmNYamzathVrUKpknOVKtVwJ7DRyzRvgTaMbDqBQMgmybBkyLljXsGbOD8j7qe8QfJomjmZrY4vOQb8fzSgp0imlTvLdf2WRC5nSRYIfJtgGH2PAzgzBbiE8mJyZ_d7M096SzSZr44j3TxDCTzNXXElTr67MUhffTmSxMt-Tfzt5aKO58bvQp8_5R98_-QqnxQ</recordid><startdate>20010206</startdate><enddate>20010206</enddate><creator>Sumida, Yasushi</creator><creator>Masuyama, Araki</creator><creator>Takasu, Mayuko</creator><creator>Kida, Toshiyuki</creator><creator>Nakatsuji, Yohji</creator><creator>Ikeda, Isao</creator><creator>Nojima, Masatomo</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20010206</creationdate><title>New pH-Sensitive Vesicles. Release Control of Trapped Materials from the Inner Aqueous Phase of Vesicles Made from Triple-Chain Amphiphiles Bearing Two Carboxylate Groups</title><author>Sumida, Yasushi ; Masuyama, Araki ; Takasu, Mayuko ; Kida, Toshiyuki ; Nakatsuji, Yohji ; Ikeda, Isao ; Nojima, Masatomo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a424t-ff0e89ebccc4da778030177c374ef9e393ba3bb9b3aa7e505a58c0e0340fb0b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological membranes</topic><topic>Lipids</topic><topic>pH effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sumida, Yasushi</creatorcontrib><creatorcontrib>Masuyama, Araki</creatorcontrib><creatorcontrib>Takasu, Mayuko</creatorcontrib><creatorcontrib>Kida, Toshiyuki</creatorcontrib><creatorcontrib>Nakatsuji, Yohji</creatorcontrib><creatorcontrib>Ikeda, Isao</creatorcontrib><creatorcontrib>Nojima, Masatomo</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Langmuir</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sumida, Yasushi</au><au>Masuyama, Araki</au><au>Takasu, Mayuko</au><au>Kida, Toshiyuki</au><au>Nakatsuji, Yohji</au><au>Ikeda, Isao</au><au>Nojima, Masatomo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New pH-Sensitive Vesicles. Release Control of Trapped Materials from the Inner Aqueous Phase of Vesicles Made from Triple-Chain Amphiphiles Bearing Two Carboxylate Groups</atitle><jtitle>Langmuir</jtitle><addtitle>Langmuir</addtitle><date>2001-02-06</date><risdate>2001</risdate><volume>17</volume><issue>3</issue><spage>609</spage><epage>612</epage><pages>609-612</pages><issn>0743-7463</issn><eissn>1520-5827</eissn><abstract>The pH-induced release of trapped materials from the inner aqueous phase of vesicles made from the synthetic triple-chain amphiphile 1 bearing two carboxyl groups was investigated. While a particular pH-dependence of the release of trapped materials from the inside of vesicles made from distearoylphosphatidylcholine (DSPC) was not observed, vesicles made from compound 1 showed unique pH-sensitive character toward the pH of the outer bulk phase as follows: it released less than 10% of 5(6)-carboxyfluorescein (CF) as a water-soluble marker at pH 7.5 after 1 year. But the vesicular assemblies were broken below pH 3.5−4.0, resulting in the liberation of the trapped CF into the bulk phase. The latter result is associated with a full-protonation of the carboxylate groups of compound 1. In the case of vesicles made from a mixture of DSPC and compound 1, the addition of cholesterol into the vesicle membranes was effective in providing clear pH-sensitive character for this type of vesicle. The ζ potentials of a series of vesicles containing compound 1 at various pH synchronized well with the pK a1 value of vesicles made from compound 1 and the pH-dependence of the release of trapped CF from these vesicles.</abstract><pub>American Chemical Society</pub><doi>10.1021/la0008939</doi><tpages>4</tpages></addata></record> |
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subjects | Biological membranes Lipids pH effects |
title | New pH-Sensitive Vesicles. Release Control of Trapped Materials from the Inner Aqueous Phase of Vesicles Made from Triple-Chain Amphiphiles Bearing Two Carboxylate Groups |
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