Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts
Pandemic 2009 H1N1 virus isolates containing the neuraminidase inhibitor resistance mutation H275Y have been reported. We describe rapid selection for the H275Y resistance mutation during therapy in 2 immunocompromised individuals at 9 and 14 days of therapy, as well as the first described case of c...
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| Veröffentlicht in: | Clinical infectious diseases 2010-05, Vol.50 (9), p.1252-1255 |
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| creator | Memoli, Matthew J Hrabal, Rachel J Hassantoufighi, Arash Eichelberger, Maryna C Taubenberger, Jeffery K |
| description | Pandemic 2009 H1N1 virus isolates containing the neuraminidase inhibitor resistance mutation H275Y have been reported. We describe rapid selection for the H275Y resistance mutation during therapy in 2 immunocompromised individuals at 9 and 14 days of therapy, as well as the first described case of clinically significant resistance to peramivir. |
| doi_str_mv | 10.1086/651605 |
| format | Article |
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| ispartof | Clinical infectious diseases, 2010-05, Vol.50 (9), p.1252-1255 |
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| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amino Acid Substitution - genetics Antiviral Agents - pharmacology Antiviral drugs Cyclopentanes - pharmacology Drug resistance Drug Resistance, Viral Drug therapy Female Guanidines - pharmacology Humans Immunocompromised Host Infectious diseases Influenza A Virus, H1N1 Subtype - drug effects Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - isolation & purification Influenza, Human - drug therapy Influenza, Human - virology Inhibitor drugs Male Middle Aged Molecular Sequence Data Mutation Mutation, Missense Oseltamivir - pharmacology Pandemics RNA, Viral - genetics Selection, Genetic Sequence Analysis, DNA Swine flu Young Adult |
| title | Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts |
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