Ten-Membered Lactones from the Marine-Derived Fungus Curvularia sp

Investigation of the secondary metabolites of the marine-derived fungus Curvularia sp. yielded four new 10-membered lactones (1−4), along with the known modiolide A (5). The structures of 1−4 were characterized on the basis of spectroscopic and MS data and resemble known 10-membered lactones, but fe...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2008-09, Vol.71 (9), p.1651-1653
Hauptverfasser:	Greve, Hendrik, Schupp, Peter J, Eguereva, Ekaterina, Kehraus, Stefan, König, Gabriele M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthophora Acanthophora spicifera algae and seaweeds Ascomycota - chemistry Biological and medical sciences chemical structure Curvularia curvulide Fundamental and applied biological sciences. Psychology lactones Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology Marine Biology marine fungi Microbial Sensitivity Tests Microbiology modiolide Molecular Structure Morphology, structure, chemical composition Mycology Rhodophyta - microbiology secondary metabolites spectral analysis
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container_end_page	1653
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container_title	Journal of natural products (Washington, D.C.)
container_volume	71
creator	Greve, Hendrik Schupp, Peter J Eguereva, Ekaterina Kehraus, Stefan König, Gabriele M
description	Investigation of the secondary metabolites of the marine-derived fungus Curvularia sp. yielded four new 10-membered lactones (1−4), along with the known modiolide A (5). The structures of 1−4 were characterized on the basis of spectroscopic and MS data and resemble known 10-membered lactones, but feature modified oxidation patterns around their macrocycles.
doi_str_mv	10.1021/np8003326
format	Article
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The structures of 1−4 were characterized on the basis of spectroscopic and MS data and resemble known 10-membered lactones, but feature modified oxidation patterns around their macrocycles.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np8003326</identifier><identifier>PMID: 18729518</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society and American Society of Pharmacognosy</publisher><subject>Acanthophora ; Acanthophora spicifera ; algae and seaweeds ; Ascomycota - chemistry ; Biological and medical sciences ; chemical structure ; Curvularia ; curvulide ; Fundamental and applied biological sciences. Psychology ; lactones ; Lactones - chemistry ; Lactones - isolation & purification ; Lactones - pharmacology ; Marine Biology ; marine fungi ; Microbial Sensitivity Tests ; Microbiology ; modiolide ; Molecular Structure ; Morphology, structure, chemical composition ; Mycology ; Rhodophyta - microbiology ; secondary metabolites ; spectral analysis</subject><ispartof>Journal of natural products (Washington, D.C.), 2008-09, Vol.71 (9), p.1651-1653</ispartof><rights>Copyright © 2008 American Chemical Society and American Society of Pharmacognosy</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a437t-e6776e59b0b8a41762f90892d58034f58f19c57c8ec13acd68268e07612c24a83</citedby><cites>FETCH-LOGICAL-a437t-e6776e59b0b8a41762f90892d58034f58f19c57c8ec13acd68268e07612c24a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np8003326$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np8003326$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20702559$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18729518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greve, Hendrik</creatorcontrib><creatorcontrib>Schupp, Peter J</creatorcontrib><creatorcontrib>Eguereva, Ekaterina</creatorcontrib><creatorcontrib>Kehraus, Stefan</creatorcontrib><creatorcontrib>König, Gabriele M</creatorcontrib><title>Ten-Membered Lactones from the Marine-Derived Fungus Curvularia sp</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Investigation of the secondary metabolites of the marine-derived fungus Curvularia sp. yielded four new 10-membered lactones (1−4), along with the known modiolide A (5). The structures of 1−4 were characterized on the basis of spectroscopic and MS data and resemble known 10-membered lactones, but feature modified oxidation patterns around their macrocycles.</description><subject>Acanthophora</subject><subject>Acanthophora spicifera</subject><subject>algae and seaweeds</subject><subject>Ascomycota - chemistry</subject><subject>Biological and medical sciences</subject><subject>chemical structure</subject><subject>Curvularia</subject><subject>curvulide</subject><subject>Fundamental and applied biological sciences. 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Nat. Prod</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>71</volume><issue>9</issue><spage>1651</spage><epage>1653</epage><pages>1651-1653</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Investigation of the secondary metabolites of the marine-derived fungus Curvularia sp. yielded four new 10-membered lactones (1−4), along with the known modiolide A (5). The structures of 1−4 were characterized on the basis of spectroscopic and MS data and resemble known 10-membered lactones, but feature modified oxidation patterns around their macrocycles.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society and American Society of Pharmacognosy</pub><pmid>18729518</pmid><doi>10.1021/np8003326</doi><tpages>3</tpages></addata></record>
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subjects	Acanthophora Acanthophora spicifera algae and seaweeds Ascomycota - chemistry Biological and medical sciences chemical structure Curvularia curvulide Fundamental and applied biological sciences. Psychology lactones Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology Marine Biology marine fungi Microbial Sensitivity Tests Microbiology modiolide Molecular Structure Morphology, structure, chemical composition Mycology Rhodophyta - microbiology secondary metabolites spectral analysis
title	Ten-Membered Lactones from the Marine-Derived Fungus Curvularia sp
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