Beta2-Microglobulin Can Be a Disease Activity Marker in Systemic Lupus Erythematosus
To investigate the clinical significance of beta2-microglobulin in Korean patients with systemic lupus erythematosus (SLE). Blood samples were collected from patients with SLE (n=100) and normal healthy controls (n=50). The level of beta2-microglobulin was investigated by enzyme-linked immunosorbent...
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| Veröffentlicht in: | The American journal of the medical sciences 2010-04, Vol.339 (4), p.337-340 |
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| container_title | The American journal of the medical sciences |
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| creator | Kim, Hyoun-Ah Jeon, Ja-Young Yoon, Jeong-Moon Suh, Chang-Hee |
| description | To investigate the clinical significance of beta2-microglobulin in Korean patients with systemic lupus erythematosus (SLE).
Blood samples were collected from patients with SLE (n=100) and normal healthy controls (n=50). The level of beta2-microglobulin was investigated by enzyme-linked immunosorbent assay. Serial samples from SLE patients were collected at 4.2±2.6months after first sampling.
The beta2-microglobulin levels of the SLE patients (2.64±0.11μg/mL) were higher than the normal controls (2.14±0.04μg/mL, P |
| doi_str_mv | 10.1097/MAJ.0b013e3181d26dfb |
| format | Article |
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Blood samples were collected from patients with SLE (n=100) and normal healthy controls (n=50). The level of beta2-microglobulin was investigated by enzyme-linked immunosorbent assay. Serial samples from SLE patients were collected at 4.2±2.6months after first sampling.
The beta2-microglobulin levels of the SLE patients (2.64±0.11μg/mL) were higher than the normal controls (2.14±0.04μg/mL, P<0.001). The patients with SLE with serositis, oral ulcer, or lupus nephritis had significantly higher beta2-microglobulin levels than those without, respectively. A significant correlation was found between the beta2-microglobulin level and each of anti-dsDNA antibody, hemoglobin, complement, and SLE Disease Activity Index. In sequential sampling of patients with SLE, a positive correlation was found between the change of the SLE Disease Activity Index and the change of the beta2-microglobulin levels.
These data suggest that the measurement of beta2-microglobulin seem to be a useful addition to the laboratory tests that can help in assessment of disease activity of SLE.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/MAJ.0b013e3181d26dfb</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>Beta2-microglobulin ; Disease activity ; Systemic lupus erythematosus</subject><ispartof>The American journal of the medical sciences, 2010-04, Vol.339 (4), p.337-340</ispartof><rights>2010 Southern Society for Clinical Investigation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-7dbf3dd493cb2fe1fb991c87c083f3ed0c3760822a76e017491740021719a5b73</citedby><cites>FETCH-LOGICAL-c338t-7dbf3dd493cb2fe1fb991c87c083f3ed0c3760822a76e017491740021719a5b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Kim, Hyoun-Ah</creatorcontrib><creatorcontrib>Jeon, Ja-Young</creatorcontrib><creatorcontrib>Yoon, Jeong-Moon</creatorcontrib><creatorcontrib>Suh, Chang-Hee</creatorcontrib><title>Beta2-Microglobulin Can Be a Disease Activity Marker in Systemic Lupus Erythematosus</title><title>The American journal of the medical sciences</title><description>To investigate the clinical significance of beta2-microglobulin in Korean patients with systemic lupus erythematosus (SLE).
Blood samples were collected from patients with SLE (n=100) and normal healthy controls (n=50). The level of beta2-microglobulin was investigated by enzyme-linked immunosorbent assay. Serial samples from SLE patients were collected at 4.2±2.6months after first sampling.
The beta2-microglobulin levels of the SLE patients (2.64±0.11μg/mL) were higher than the normal controls (2.14±0.04μg/mL, P<0.001). The patients with SLE with serositis, oral ulcer, or lupus nephritis had significantly higher beta2-microglobulin levels than those without, respectively. A significant correlation was found between the beta2-microglobulin level and each of anti-dsDNA antibody, hemoglobin, complement, and SLE Disease Activity Index. In sequential sampling of patients with SLE, a positive correlation was found between the change of the SLE Disease Activity Index and the change of the beta2-microglobulin levels.
These data suggest that the measurement of beta2-microglobulin seem to be a useful addition to the laboratory tests that can help in assessment of disease activity of SLE.</description><subject>Beta2-microglobulin</subject><subject>Disease activity</subject><subject>Systemic lupus erythematosus</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kDtPwzAUhS0EEqXwDxi8MaX4kcbxgtSW8lIrBspsOfYNGJKm2E6l_HuMysSAro7u8p0jnYPQJSUTSqS4Xs-eJqQilAOnJbWssHV1hEZ0ysuMSUmO0YgQwjJZMHmKzkL4IISykvIR2swhapatnfHdW9NVfeO2eKG3eA5Y41sXQAfAMxPd3sUBr7X_BI8T8zKECK0zeNXv-oCXfojv0OrYhT6co5NaNwEufv8Yvd4tN4uHbPV8_7iYrTLDeRkzYauaW5tLbipWA60rKakphSElrzlYYrgoSMmYFgUQKnKZlHpQQaWeVoKP0dUhd-e7rx5CVK0LBppGb6HrgxLTPB0lLJH5gUw1Q_BQq513rfaDokT9bKjShurvhsl2c7BBarF34FUwDrYGrPNgorKd-z_gG9c6emw</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Kim, Hyoun-Ah</creator><creator>Jeon, Ja-Young</creator><creator>Yoon, Jeong-Moon</creator><creator>Suh, Chang-Hee</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20100401</creationdate><title>Beta2-Microglobulin Can Be a Disease Activity Marker in Systemic Lupus Erythematosus</title><author>Kim, Hyoun-Ah ; Jeon, Ja-Young ; Yoon, Jeong-Moon ; Suh, Chang-Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-7dbf3dd493cb2fe1fb991c87c083f3ed0c3760822a76e017491740021719a5b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Beta2-microglobulin</topic><topic>Disease activity</topic><topic>Systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hyoun-Ah</creatorcontrib><creatorcontrib>Jeon, Ja-Young</creatorcontrib><creatorcontrib>Yoon, Jeong-Moon</creatorcontrib><creatorcontrib>Suh, Chang-Hee</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hyoun-Ah</au><au>Jeon, Ja-Young</au><au>Yoon, Jeong-Moon</au><au>Suh, Chang-Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beta2-Microglobulin Can Be a Disease Activity Marker in Systemic Lupus Erythematosus</atitle><jtitle>The American journal of the medical sciences</jtitle><date>2010-04-01</date><risdate>2010</risdate><volume>339</volume><issue>4</issue><spage>337</spage><epage>340</epage><pages>337-340</pages><issn>0002-9629</issn><eissn>1538-2990</eissn><abstract>To investigate the clinical significance of beta2-microglobulin in Korean patients with systemic lupus erythematosus (SLE).
Blood samples were collected from patients with SLE (n=100) and normal healthy controls (n=50). The level of beta2-microglobulin was investigated by enzyme-linked immunosorbent assay. Serial samples from SLE patients were collected at 4.2±2.6months after first sampling.
The beta2-microglobulin levels of the SLE patients (2.64±0.11μg/mL) were higher than the normal controls (2.14±0.04μg/mL, P<0.001). The patients with SLE with serositis, oral ulcer, or lupus nephritis had significantly higher beta2-microglobulin levels than those without, respectively. A significant correlation was found between the beta2-microglobulin level and each of anti-dsDNA antibody, hemoglobin, complement, and SLE Disease Activity Index. In sequential sampling of patients with SLE, a positive correlation was found between the change of the SLE Disease Activity Index and the change of the beta2-microglobulin levels.
These data suggest that the measurement of beta2-microglobulin seem to be a useful addition to the laboratory tests that can help in assessment of disease activity of SLE.</abstract><pub>Elsevier Inc</pub><doi>10.1097/MAJ.0b013e3181d26dfb</doi><tpages>4</tpages></addata></record> |
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| subjects | Beta2-microglobulin Disease activity Systemic lupus erythematosus |
| title | Beta2-Microglobulin Can Be a Disease Activity Marker in Systemic Lupus Erythematosus |
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