Fulminant Infectious Mononucleosis and Recurrent Epstein-Barr Virus Reactivation in an Adolescent

We describe a unique case of fulminant infectious mononucleosis and recurrent Epstein-Barr virus reactivation presenting in an adolescent. Detailed assays of Epstein-Barr virus–specific T cell immunity revealed defects in the patient's T cell receptor signalling pathway characterized by a lack...

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Veröffentlicht in:	Clinical infectious diseases 2010-03, Vol.50 (6), p.e34-e37
Hauptverfasser:	Nourse, Jamie P., Jones, Kimberley, Dua, Ujjwal, Runnegar, Naomi, Looke, David, Schmidt, Chris, Tey, Siok-Keen, Kennedy, Glen, Gandhi, Maher K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Child Epstein-Barr virus Herpesvirus 4, Human - immunology Herpesvirus 4, Human - isolation & purification Humans Infectious Mononucleosis - diagnosis Infectious Mononucleosis - immunology Infectious Mononucleosis - therapy Interleukin-2 - deficiency Interleukin-2 Receptor alpha Subunit - deficiency Receptors, Antigen, T-Cell - deficiency Recurrence Stem Cell Transplantation T-Lymphocytes - immunology Virus Activation Young Adult
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Zusammenfassung:	We describe a unique case of fulminant infectious mononucleosis and recurrent Epstein-Barr virus reactivation presenting in an adolescent. Detailed assays of Epstein-Barr virus–specific T cell immunity revealed defects in the patient's T cell receptor signalling pathway characterized by a lack of interleukin-2 and CD25 expression, which may have contributed to her clinical course. Allogeneic stem cell transplantation reversed the clinical and laboratory phenotype.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/650007