In vivo [ 3H]spiperone binding to the rat hippocampal formation: Involvement of dopamine receptors
The existence of DA receptors in the rat hippocampus was demonstrated with an in vivo [ 3H]spiperone radio-receptor assay. Kinetic studies revealed that maximum binding of [ 3H]spiperone in hippocampus was much smaller than in striatum and frontal cortex but much higher than in cerebellum. In inhibi...
Gespeichert in:
| Veröffentlicht in: | European journal of pharmacology 1980-12, Vol.68 (3), p.305-315 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 315 |
|---|---|
| container_issue | 3 |
| container_start_page | 305 |
| container_title | European journal of pharmacology |
| container_volume | 68 |
| creator | Bischoff, S. Bittiger, H. Krauss, J. |
| description | The existence of DA receptors in the rat hippocampus was demonstrated with an in vivo [
3H]spiperone radio-receptor assay. Kinetic studies revealed that maximum binding of [
3H]spiperone in hippocampus was much smaller than in striatum and frontal cortex but much higher than in cerebellum. In inhibition studies of [
3H]spiperone binding, all neuroleptics tested were active in hippocampus as well as in striatum. In contrast, 5HT antagonists were definetely less potent in these two brain regions than in frontal cortex. Finally, even when 5HT receptors were blocked, dipropyl-ATN and haloperidol remained fully effective in hippocampus, striatum, but also in frontal cortex although to a lesser degree. From these results it was concluded that [
3H]spiperone binds mainly to DA receptors in hippocampus as well as in striamtum, whereas both 5HT and DA receptors are present in frontal cortex. |
| doi_str_mv | 10.1016/0014-2999(80)90528-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75454227</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0014299980905282</els_id><sourcerecordid>75454227</sourcerecordid><originalsourceid>FETCH-LOGICAL-c338t-4079d929dbf62d24daaed1c97776f287db51a816e9860d9c5cada121a957844b3</originalsourceid><addsrcrecordid>eNp9kE1rHCEYx6UkpJuk36AFT6E5TKquM2oPgRDyshDopTmVIo4-01hm1Ko70G_f2e6SY07P4f_G80PoIyVXlNDuCyGUN0wp9VmSS0VaJhv2Dq2oFKohgrIjtHq1vEenpfwmhLSKtSfoRDDCuOIr1G8Cnv0c8Q-8fvxZkk-QYwDc--B8-IVrxPUFcDYVv_iUojVTMiMeYp5M9TF8xZswx3GGCULFccAuJjP5pSGDhVRjLufoeDBjgQ-He4ae7---3z42T98eNrc3T41dr2VtOBHKKaZcP3TMMe6MAUetEkJ0A5PC9S01knagZEecsq01zlBGjWqF5Lxfn6GLfW_K8c8WStWTLxbG0QSI26JFy1vOmFiMfG-0OZaSYdAp-8nkv5oSvUOrd9z0jpuWRP9Hq9kS-3To3_YTuNfQgeWiX-91WJ6cPWRdrIdgwfmFRdUu-rcH_gEyTIjd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75454227</pqid></control><display><type>article</type><title>In vivo [ 3H]spiperone binding to the rat hippocampal formation: Involvement of dopamine receptors</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Bischoff, S. ; Bittiger, H. ; Krauss, J.</creator><creatorcontrib>Bischoff, S. ; Bittiger, H. ; Krauss, J.</creatorcontrib><description>The existence of DA receptors in the rat hippocampus was demonstrated with an in vivo [
3H]spiperone radio-receptor assay. Kinetic studies revealed that maximum binding of [
3H]spiperone in hippocampus was much smaller than in striatum and frontal cortex but much higher than in cerebellum. In inhibition studies of [
3H]spiperone binding, all neuroleptics tested were active in hippocampus as well as in striatum. In contrast, 5HT antagonists were definetely less potent in these two brain regions than in frontal cortex. Finally, even when 5HT receptors were blocked, dipropyl-ATN and haloperidol remained fully effective in hippocampus, striatum, but also in frontal cortex although to a lesser degree. From these results it was concluded that [
3H]spiperone binds mainly to DA receptors in hippocampus as well as in striamtum, whereas both 5HT and DA receptors are present in frontal cortex.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(80)90528-2</identifier><identifier>PMID: 7202494</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>5HT receptors ; [ 3H]Spiperone binding in vivo ; Animals ; Binding, Competitive ; Butyrophenones - metabolism ; Cerebral Cortex - metabolism ; Corpus Striatum - metabolism ; DA receptors ; Frontal cortex ; Hippocampus ; Hippocampus - metabolism ; Kinetics ; Male ; Rats ; Receptors, Dopamine - metabolism ; Receptors, Serotonin - metabolism ; Spiperone - metabolism ; Striatum</subject><ispartof>European journal of pharmacology, 1980-12, Vol.68 (3), p.305-315</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-4079d929dbf62d24daaed1c97776f287db51a816e9860d9c5cada121a957844b3</citedby><cites>FETCH-LOGICAL-c338t-4079d929dbf62d24daaed1c97776f287db51a816e9860d9c5cada121a957844b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(80)90528-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7202494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bischoff, S.</creatorcontrib><creatorcontrib>Bittiger, H.</creatorcontrib><creatorcontrib>Krauss, J.</creatorcontrib><title>In vivo [ 3H]spiperone binding to the rat hippocampal formation: Involvement of dopamine receptors</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The existence of DA receptors in the rat hippocampus was demonstrated with an in vivo [
3H]spiperone radio-receptor assay. Kinetic studies revealed that maximum binding of [
3H]spiperone in hippocampus was much smaller than in striatum and frontal cortex but much higher than in cerebellum. In inhibition studies of [
3H]spiperone binding, all neuroleptics tested were active in hippocampus as well as in striatum. In contrast, 5HT antagonists were definetely less potent in these two brain regions than in frontal cortex. Finally, even when 5HT receptors were blocked, dipropyl-ATN and haloperidol remained fully effective in hippocampus, striatum, but also in frontal cortex although to a lesser degree. From these results it was concluded that [
3H]spiperone binds mainly to DA receptors in hippocampus as well as in striamtum, whereas both 5HT and DA receptors are present in frontal cortex.</description><subject>5HT receptors</subject><subject>[ 3H]Spiperone binding in vivo</subject><subject>Animals</subject><subject>Binding, Competitive</subject><subject>Butyrophenones - metabolism</subject><subject>Cerebral Cortex - metabolism</subject><subject>Corpus Striatum - metabolism</subject><subject>DA receptors</subject><subject>Frontal cortex</subject><subject>Hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>Kinetics</subject><subject>Male</subject><subject>Rats</subject><subject>Receptors, Dopamine - metabolism</subject><subject>Receptors, Serotonin - metabolism</subject><subject>Spiperone - metabolism</subject><subject>Striatum</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rHCEYx6UkpJuk36AFT6E5TKquM2oPgRDyshDopTmVIo4-01hm1Ko70G_f2e6SY07P4f_G80PoIyVXlNDuCyGUN0wp9VmSS0VaJhv2Dq2oFKohgrIjtHq1vEenpfwmhLSKtSfoRDDCuOIr1G8Cnv0c8Q-8fvxZkk-QYwDc--B8-IVrxPUFcDYVv_iUojVTMiMeYp5M9TF8xZswx3GGCULFccAuJjP5pSGDhVRjLufoeDBjgQ-He4ae7---3z42T98eNrc3T41dr2VtOBHKKaZcP3TMMe6MAUetEkJ0A5PC9S01knagZEecsq01zlBGjWqF5Lxfn6GLfW_K8c8WStWTLxbG0QSI26JFy1vOmFiMfG-0OZaSYdAp-8nkv5oSvUOrd9z0jpuWRP9Hq9kS-3To3_YTuNfQgeWiX-91WJ6cPWRdrIdgwfmFRdUu-rcH_gEyTIjd</recordid><startdate>19801205</startdate><enddate>19801205</enddate><creator>Bischoff, S.</creator><creator>Bittiger, H.</creator><creator>Krauss, J.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19801205</creationdate><title>In vivo [ 3H]spiperone binding to the rat hippocampal formation: Involvement of dopamine receptors</title><author>Bischoff, S. ; Bittiger, H. ; Krauss, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-4079d929dbf62d24daaed1c97776f287db51a816e9860d9c5cada121a957844b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>5HT receptors</topic><topic>[ 3H]Spiperone binding in vivo</topic><topic>Animals</topic><topic>Binding, Competitive</topic><topic>Butyrophenones - metabolism</topic><topic>Cerebral Cortex - metabolism</topic><topic>Corpus Striatum - metabolism</topic><topic>DA receptors</topic><topic>Frontal cortex</topic><topic>Hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>Kinetics</topic><topic>Male</topic><topic>Rats</topic><topic>Receptors, Dopamine - metabolism</topic><topic>Receptors, Serotonin - metabolism</topic><topic>Spiperone - metabolism</topic><topic>Striatum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bischoff, S.</creatorcontrib><creatorcontrib>Bittiger, H.</creatorcontrib><creatorcontrib>Krauss, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bischoff, S.</au><au>Bittiger, H.</au><au>Krauss, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo [ 3H]spiperone binding to the rat hippocampal formation: Involvement of dopamine receptors</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1980-12-05</date><risdate>1980</risdate><volume>68</volume><issue>3</issue><spage>305</spage><epage>315</epage><pages>305-315</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>The existence of DA receptors in the rat hippocampus was demonstrated with an in vivo [
3H]spiperone radio-receptor assay. Kinetic studies revealed that maximum binding of [
3H]spiperone in hippocampus was much smaller than in striatum and frontal cortex but much higher than in cerebellum. In inhibition studies of [
3H]spiperone binding, all neuroleptics tested were active in hippocampus as well as in striatum. In contrast, 5HT antagonists were definetely less potent in these two brain regions than in frontal cortex. Finally, even when 5HT receptors were blocked, dipropyl-ATN and haloperidol remained fully effective in hippocampus, striatum, but also in frontal cortex although to a lesser degree. From these results it was concluded that [
3H]spiperone binds mainly to DA receptors in hippocampus as well as in striamtum, whereas both 5HT and DA receptors are present in frontal cortex.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>7202494</pmid><doi>10.1016/0014-2999(80)90528-2</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1980-12, Vol.68 (3), p.305-315 |
| issn | 0014-2999 1879-0712 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75454227 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 5HT receptors [ 3H]Spiperone binding in vivo Animals Binding, Competitive Butyrophenones - metabolism Cerebral Cortex - metabolism Corpus Striatum - metabolism DA receptors Frontal cortex Hippocampus Hippocampus - metabolism Kinetics Male Rats Receptors, Dopamine - metabolism Receptors, Serotonin - metabolism Spiperone - metabolism Striatum |
| title | In vivo [ 3H]spiperone binding to the rat hippocampal formation: Involvement of dopamine receptors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T10%3A44%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20vivo%20%5B%203H%5Dspiperone%20binding%20to%20the%20rat%20hippocampal%20formation:%20Involvement%20of%20dopamine%20receptors&rft.jtitle=European%20journal%20of%20pharmacology&rft.au=Bischoff,%20S.&rft.date=1980-12-05&rft.volume=68&rft.issue=3&rft.spage=305&rft.epage=315&rft.pages=305-315&rft.issn=0014-2999&rft.eissn=1879-0712&rft_id=info:doi/10.1016/0014-2999(80)90528-2&rft_dat=%3Cproquest_cross%3E75454227%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75454227&rft_id=info:pmid/7202494&rft_els_id=0014299980905282&rfr_iscdi=true |