Evaluation of the long-term results of rat cranial bone repair using a particular xenograft
Bone defects that cannot be healed completely are termed critical-sized defects and can be used to test bone grafts for medicine, dentistry, and periodontology. The aim of the present study was to detect the effects of a xenograft (Unilab Surgibone) on bone building in experimentally created parieta...
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| Veröffentlicht in: | The Journal of oral implantology 2010-01, Vol.36 (3), p.167-173 |
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| creator | Develioglu, Hakan Saraydin, Serpilünver Kartal, Unal Taner, Levent |
| description | Bone defects that cannot be healed completely are termed critical-sized defects and can be used to test bone grafts for medicine, dentistry, and periodontology. The aim of the present study was to detect the effects of a xenograft (Unilab Surgibone) on bone building in experimentally created parietal bone defects in rats. Standardized parietal bone defects were created in 16 rats, and each defect had a circular morphology 6 mm in diameter. The right defect sites were filled with porous particle material, and the left site was used as control. After the 3rd, 6th, and 12th months, rats were killed and tissue samples obtained from the related site of the cranium. Subsequently, histological sections were taken and stained with different stains for evaluation under light microscope. The rate of bone formation was assessed using a semiquantitative method. These results showed that dense collagenous tissue was observed in the control area during the third month, whereas xenograft particles were surrounded by a fibrous tissue layer at the implantation site. Osteoclast-like cells were also observed. There was also no significant bone repair at other observation periods. It can be concluded that the material used had no evidence of resorption and does not enhance bone formation. However, it seems biocompatible, osteoconductive, and could be used in a limited manner as a material for filling osseous defects in clinical practice. |
| doi_str_mv | 10.1563/AAID-JOI-D-09-00064 |
| format | Article |
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The aim of the present study was to detect the effects of a xenograft (Unilab Surgibone) on bone building in experimentally created parietal bone defects in rats. Standardized parietal bone defects were created in 16 rats, and each defect had a circular morphology 6 mm in diameter. The right defect sites were filled with porous particle material, and the left site was used as control. After the 3rd, 6th, and 12th months, rats were killed and tissue samples obtained from the related site of the cranium. Subsequently, histological sections were taken and stained with different stains for evaluation under light microscope. The rate of bone formation was assessed using a semiquantitative method. These results showed that dense collagenous tissue was observed in the control area during the third month, whereas xenograft particles were surrounded by a fibrous tissue layer at the implantation site. Osteoclast-like cells were also observed. There was also no significant bone repair at other observation periods. It can be concluded that the material used had no evidence of resorption and does not enhance bone formation. However, it seems biocompatible, osteoconductive, and could be used in a limited manner as a material for filling osseous defects in clinical practice.</description><identifier>ISSN: 0160-6972</identifier><identifier>EISSN: 1548-1336</identifier><identifier>DOI: 10.1563/AAID-JOI-D-09-00064</identifier><identifier>PMID: 20553170</identifier><language>eng</language><publisher>United States: Allen Press Inc</publisher><subject>Animals ; Azo Compounds ; Biocompatible Materials - therapeutic use ; Biomedical materials ; Bone Diseases - pathology ; Bone Diseases - surgery ; Bone Matrix - pathology ; Bone Regeneration - physiology ; Bone Substitutes - therapeutic use ; Cattle ; Clinical medicine ; Collagen - therapeutic use ; Coloring Agents ; Connective Tissue - pathology ; Craniotomy ; Dentistry ; Durapatite - therapeutic use ; Eosine Yellowish-(YS) ; Fluorescent Dyes ; Hematoxylin ; Methyl Green ; Osteoblasts - pathology ; Osteoclasts - pathology ; Osteocytes - pathology ; Osteogenesis - physiology ; Parietal Bone - pathology ; Parietal Bone - surgery ; Pore size ; Rats ; Rats, Wistar ; Rodents ; Time Factors ; Transplantation, Heterologous</subject><ispartof>The Journal of oral implantology, 2010-01, Vol.36 (3), p.167-173</ispartof><rights>Copyright Allen Press Publishing Services 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-ab532efdaae26be5667c1196d81f67ec0d182dfcd6c1b35ee8ca9a09287d65f53</citedby><cites>FETCH-LOGICAL-c363t-ab532efdaae26be5667c1196d81f67ec0d182dfcd6c1b35ee8ca9a09287d65f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20553170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Develioglu, Hakan</creatorcontrib><creatorcontrib>Saraydin, Serpilünver</creatorcontrib><creatorcontrib>Kartal, Unal</creatorcontrib><creatorcontrib>Taner, Levent</creatorcontrib><title>Evaluation of the long-term results of rat cranial bone repair using a particular xenograft</title><title>The Journal of oral implantology</title><addtitle>J Oral Implantol</addtitle><description>Bone defects that cannot be healed completely are termed critical-sized defects and can be used to test bone grafts for medicine, dentistry, and periodontology. The aim of the present study was to detect the effects of a xenograft (Unilab Surgibone) on bone building in experimentally created parietal bone defects in rats. Standardized parietal bone defects were created in 16 rats, and each defect had a circular morphology 6 mm in diameter. The right defect sites were filled with porous particle material, and the left site was used as control. After the 3rd, 6th, and 12th months, rats were killed and tissue samples obtained from the related site of the cranium. Subsequently, histological sections were taken and stained with different stains for evaluation under light microscope. The rate of bone formation was assessed using a semiquantitative method. These results showed that dense collagenous tissue was observed in the control area during the third month, whereas xenograft particles were surrounded by a fibrous tissue layer at the implantation site. Osteoclast-like cells were also observed. There was also no significant bone repair at other observation periods. It can be concluded that the material used had no evidence of resorption and does not enhance bone formation. However, it seems biocompatible, osteoconductive, and could be used in a limited manner as a material for filling osseous defects in clinical practice.</description><subject>Animals</subject><subject>Azo Compounds</subject><subject>Biocompatible Materials - therapeutic use</subject><subject>Biomedical materials</subject><subject>Bone Diseases - pathology</subject><subject>Bone Diseases - surgery</subject><subject>Bone Matrix - pathology</subject><subject>Bone Regeneration - physiology</subject><subject>Bone Substitutes - therapeutic use</subject><subject>Cattle</subject><subject>Clinical medicine</subject><subject>Collagen - therapeutic use</subject><subject>Coloring Agents</subject><subject>Connective Tissue - pathology</subject><subject>Craniotomy</subject><subject>Dentistry</subject><subject>Durapatite - therapeutic use</subject><subject>Eosine Yellowish-(YS)</subject><subject>Fluorescent Dyes</subject><subject>Hematoxylin</subject><subject>Methyl Green</subject><subject>Osteoblasts - pathology</subject><subject>Osteoclasts - pathology</subject><subject>Osteocytes - pathology</subject><subject>Osteogenesis - physiology</subject><subject>Parietal Bone - pathology</subject><subject>Parietal Bone - surgery</subject><subject>Pore size</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Time Factors</subject><subject>Transplantation, Heterologous</subject><issn>0160-6972</issn><issn>1548-1336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1P3DAURS1UBMPHL6hUWd2wcusXx3ayHDFAp0JiQ1ddWC_OyzQoE09tB5V_TwZoF92weot77pWeDmMfQX4BbdTX5XK9Et_v1mIlZC2klKY8YAvQZSVAKfOBLSQYKUxti2N2ktKDlIXWGo7YcSG1VmDlgv28esRhwtyHkYeO51_EhzBuRKa45ZHSNOS0DyJm7iOOPQ68CSPN2Q77yKfUjxuOfIcx934aMPI_NIZNxC6fscMOh0Tnb_eU_bi-ur_8Jm7vbtaXy1vhlVFZYKNVQV2LSIVpSBtjPUBt2go6Y8nLFqqi7XxrPDRKE1Uea5R1UdnW6E6rU3bxuruL4fdEKbttnzwNA44UpuSsLnUJoKv3SaXqSpZQzOTn_8iHMMVxfsNpa422qoQZUq-QjyGlSJ3bxX6L8cmBdHtHbu_IzY7cysnavTiaW5_epqdmS-2_zl8p6hm2LY3I</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Develioglu, Hakan</creator><creator>Saraydin, Serpilünver</creator><creator>Kartal, Unal</creator><creator>Taner, Levent</creator><general>Allen Press Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20100101</creationdate><title>Evaluation of the long-term results of rat cranial bone repair using a particular xenograft</title><author>Develioglu, Hakan ; Saraydin, Serpilünver ; Kartal, Unal ; Taner, Levent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-ab532efdaae26be5667c1196d81f67ec0d182dfcd6c1b35ee8ca9a09287d65f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Azo Compounds</topic><topic>Biocompatible Materials - 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Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The Journal of oral implantology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Develioglu, Hakan</au><au>Saraydin, Serpilünver</au><au>Kartal, Unal</au><au>Taner, Levent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the long-term results of rat cranial bone repair using a particular xenograft</atitle><jtitle>The Journal of oral implantology</jtitle><addtitle>J Oral Implantol</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>36</volume><issue>3</issue><spage>167</spage><epage>173</epage><pages>167-173</pages><issn>0160-6972</issn><eissn>1548-1336</eissn><abstract>Bone defects that cannot be healed completely are termed critical-sized defects and can be used to test bone grafts for medicine, dentistry, and periodontology. The aim of the present study was to detect the effects of a xenograft (Unilab Surgibone) on bone building in experimentally created parietal bone defects in rats. Standardized parietal bone defects were created in 16 rats, and each defect had a circular morphology 6 mm in diameter. The right defect sites were filled with porous particle material, and the left site was used as control. After the 3rd, 6th, and 12th months, rats were killed and tissue samples obtained from the related site of the cranium. Subsequently, histological sections were taken and stained with different stains for evaluation under light microscope. The rate of bone formation was assessed using a semiquantitative method. These results showed that dense collagenous tissue was observed in the control area during the third month, whereas xenograft particles were surrounded by a fibrous tissue layer at the implantation site. Osteoclast-like cells were also observed. There was also no significant bone repair at other observation periods. It can be concluded that the material used had no evidence of resorption and does not enhance bone formation. However, it seems biocompatible, osteoconductive, and could be used in a limited manner as a material for filling osseous defects in clinical practice.</abstract><cop>United States</cop><pub>Allen Press Inc</pub><pmid>20553170</pmid><doi>10.1563/AAID-JOI-D-09-00064</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0160-6972 |
| ispartof | The Journal of oral implantology, 2010-01, Vol.36 (3), p.167-173 |
| issn | 0160-6972 1548-1336 |
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| source | MEDLINE; Allen Press Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Azo Compounds Biocompatible Materials - therapeutic use Biomedical materials Bone Diseases - pathology Bone Diseases - surgery Bone Matrix - pathology Bone Regeneration - physiology Bone Substitutes - therapeutic use Cattle Clinical medicine Collagen - therapeutic use Coloring Agents Connective Tissue - pathology Craniotomy Dentistry Durapatite - therapeutic use Eosine Yellowish-(YS) Fluorescent Dyes Hematoxylin Methyl Green Osteoblasts - pathology Osteoclasts - pathology Osteocytes - pathology Osteogenesis - physiology Parietal Bone - pathology Parietal Bone - surgery Pore size Rats Rats, Wistar Rodents Time Factors Transplantation, Heterologous |
| title | Evaluation of the long-term results of rat cranial bone repair using a particular xenograft |
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