Mechanism and Specificity of a Symmetrical Benzimidazolephenylcarboxamide Helicase Inhibitor

This study examines the effects of 1-N,4-N-bis[4-(1H-benzimidazol-2-yl)phenyl]benzene-1,4-dicarboxamide ((BIP)2B) on the NS3 helicase encoded by the hepatitis C virus (HCV). Molecular beacon-based helicase assays were used to show that (BIP)2B inhibits the ability of HCV helicase to separate a varie...

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