Inverse Correlation of Thermal Lability and Conversion Efficiency for Five Prion Protein Polymorphic Variants

Transmissible spongiform encephalopathies (TSEs) are associated with the accumulation of deposits of an abnormal form, PrPSc, of the host-encoded prion protein, PrPC. Amino acid substitutions in PrPC have long been known to affect TSE disease outcome. In extreme cases in humans, various mutations ap...

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