Molecular and Clinical Assessment in the Treatment of AIDS Kaposi Sarcoma with Valproic Acid
The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS). Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria fo...
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| Veröffentlicht in: | Clinical infectious diseases 2009-12, Vol.49 (12), p.1946-1946 |
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| container_end_page | 1946 |
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| container_issue | 12 |
| container_start_page | 1946 |
| container_title | Clinical infectious diseases |
| container_volume | 49 |
| creator | Lechowicz, Maryjo Dittmer, Dirk P. Lee, Jeannette Y. Krown, Susan E. Wachsman, William Aboulafia, David Dezube, Bruce J. Ratner, Lee Said, Jonathan Ambinder, Richard F. |
| description | The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS). Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria for efficacy. |
| doi_str_mv | 10.1086/648447 |
| format | Article |
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Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria for efficacy.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/648447</identifier><identifier>PMID: 19911999</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Oxford: The University of Chicago Press</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - complications ; Adult ; AIDS ; Biological and medical sciences ; Blood ; Chemical compounds ; Clinical trials ; Dermatology ; Female ; Herpesviridae ; Herpesvirus ; Herpesvirus 8, Human - isolation & purification ; HIV ; HIV/AIDS ; Human herpesvirus 8 ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Kaposi sarcoma ; Kaposis sarcoma ; Male ; Medical sciences ; Medical treatment ; Messenger RNA ; Middle Aged ; Prospective Studies ; RNA ; RNA, Viral - analysis ; Sarcoma, Kaposi - drug therapy ; T lymphocytes ; Toxicity ; Tumors ; Tumors of the skin and soft tissue. Premalignant lesions ; Valproic Acid - therapeutic use ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Clinical infectious diseases, 2009-12, Vol.49 (12), p.1946-1946</ispartof><rights>2009 Infectious Diseases Society of America</rights><rights>2009 by the Infectious Diseases Society of America 2009</rights><rights>2015 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Dec 15, 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-96614ab7ce6cdbcdf4d723ee9aaad56f15982f91f7ca32bcad8a6bc7d22c98e43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/27799477$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/27799477$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,782,786,805,27933,27934,58026,58259</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22208714$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19911999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lechowicz, Maryjo</creatorcontrib><creatorcontrib>Dittmer, Dirk P.</creatorcontrib><creatorcontrib>Lee, Jeannette Y.</creatorcontrib><creatorcontrib>Krown, Susan E.</creatorcontrib><creatorcontrib>Wachsman, William</creatorcontrib><creatorcontrib>Aboulafia, David</creatorcontrib><creatorcontrib>Dezube, Bruce J.</creatorcontrib><creatorcontrib>Ratner, Lee</creatorcontrib><creatorcontrib>Said, Jonathan</creatorcontrib><creatorcontrib>Ambinder, Richard F.</creatorcontrib><title>Molecular and Clinical Assessment in the Treatment of AIDS Kaposi Sarcoma with Valproic Acid</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS). Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria for efficacy.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Adult</subject><subject>AIDS</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Chemical compounds</subject><subject>Clinical trials</subject><subject>Dermatology</subject><subject>Female</subject><subject>Herpesviridae</subject><subject>Herpesvirus</subject><subject>Herpesvirus 8, Human - isolation & purification</subject><subject>HIV</subject><subject>HIV/AIDS</subject><subject>Human herpesvirus 8</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infectious diseases</subject><subject>Kaposi sarcoma</subject><subject>Kaposis sarcoma</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Messenger RNA</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>RNA</subject><subject>RNA, Viral - analysis</subject><subject>Sarcoma, Kaposi - drug therapy</subject><subject>T lymphocytes</subject><subject>Toxicity</subject><subject>Tumors</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><subject>Valproic Acid - therapeutic use</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infectious diseases</topic><topic>Kaposi sarcoma</topic><topic>Kaposis sarcoma</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Messenger RNA</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>RNA</topic><topic>RNA, Viral - analysis</topic><topic>Sarcoma, Kaposi - drug therapy</topic><topic>T lymphocytes</topic><topic>Toxicity</topic><topic>Tumors</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><topic>Valproic Acid - therapeutic use</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. 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| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2009-12, Vol.49 (12), p.1946-1946 |
| issn | 1058-4838 1537-6591 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_754540088 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - complications Adult AIDS Biological and medical sciences Blood Chemical compounds Clinical trials Dermatology Female Herpesviridae Herpesvirus Herpesvirus 8, Human - isolation & purification HIV HIV/AIDS Human herpesvirus 8 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Kaposi sarcoma Kaposis sarcoma Male Medical sciences Medical treatment Messenger RNA Middle Aged Prospective Studies RNA RNA, Viral - analysis Sarcoma, Kaposi - drug therapy T lymphocytes Toxicity Tumors Tumors of the skin and soft tissue. Premalignant lesions Valproic Acid - therapeutic use Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Molecular and Clinical Assessment in the Treatment of AIDS Kaposi Sarcoma with Valproic Acid |
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