Nicotine replacement in abstinent smokers improves cognitive withdrawal symptoms with modulation of resting brain network dynamics

Symptoms of cognitive impairment during smoking withdrawal can be ameliorated by nicotine replacement. To define brain mechanisms contributing to this therapeutic effect, we conducted a functional connectivity analysis of resting-state fMRI in 17 abstinent smokers following nicotine replacement in a...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2010-08, Vol.52 (2), p.590-599
Hauptverfasser:	Cole, David M., Beckmann, Christian F., Long, Christopher J., Matthews, Paul M., Durcan, Michael J., Beaver, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Brain - drug effects Brain - physiopathology Brain Mapping Brain research Cognition Cognition Disorders - drug therapy Cognition Disorders - etiology Cognitive ability Cross-Over Studies Default mode Double-Blind Method Drug dosages Executive control Executive Function - drug effects Executive Function - physiology Female fMRI Functional connectivity Humans Independent component analysis Magnetic Resonance Imaging Male Middle Aged Networks Neural Pathways - drug effects Neural Pathways - physiopathology Neuropsychological Tests Nicotine Nicotine - pharmacology Nicotinic Agonists - pharmacology NMR Nuclear magnetic resonance Resting state Smoking Smoking - drug therapy Smoking - physiopathology Studies Substance abuse treatment Substance Withdrawal Syndrome - complications Substance Withdrawal Syndrome - drug therapy Withdrawal Young Adult
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