Toxico-pathological changes induced by cypermethrin in broiler chicks: Their attenuation with Vitamin E and selenium
Ninety 1-day old broiler chicks of mixed gender (as hatched) procured from a local hatchery were randomly divided into five equal groups. All the treatments were given through crop tubing. Groups 1–4 received cypermethrin (CY) (600 mg kg −1 b. wt.) daily for 30 days. In addition to CY (group 1), gro...
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| Veröffentlicht in: | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2010-07, Vol.62 (4), p.441-450 |
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| creator | Aslam, Faiza Khan, Ahrar Khan, Muhammad Zargham Sharaf, Summaira Gul, Shafia Tahseen Saleemi, Muhammad Kashif |
| description | Ninety 1-day old broiler chicks of mixed gender (as hatched) procured from a local hatchery were randomly divided into five equal groups. All the treatments were given through crop tubing. Groups 1–4 received cypermethrin (CY) (600
mg
kg
−1
b. wt.) daily for 30 days. In addition to CY (group 1), groups 2–4 received Vit E (150
mg
kg
−1
b. wt.), Se (0.25
mg
kg
−1
b. wt.), and Vit E (150
mg
kg
−1
b. wt.)+Se (0.25
mg
kg
−1
b. wt.), respectively. Group 5 served as control andreceived normal saline (2
ml
kg
−1
b. wt.) for 30 days. Randomly selected six broiler chicks from each group were slaughtered at experimental days 10, 20 and 30 for the collection of serum/plasma and morbid tissues. Absolute organ weights were recorded. Total plasma proteins, fibrinogen and creatinine were significantly (
P |
| doi_str_mv | 10.1016/j.etp.2009.06.004 |
| format | Article |
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mg
kg
−1
b. wt.) daily for 30 days. In addition to CY (group 1), groups 2–4 received Vit E (150
mg
kg
−1
b. wt.), Se (0.25
mg
kg
−1
b. wt.), and Vit E (150
mg
kg
−1
b. wt.)+Se (0.25
mg
kg
−1
b. wt.), respectively. Group 5 served as control andreceived normal saline (2
ml
kg
−1
b. wt.) for 30 days. Randomly selected six broiler chicks from each group were slaughtered at experimental days 10, 20 and 30 for the collection of serum/plasma and morbid tissues. Absolute organ weights were recorded. Total plasma proteins, fibrinogen and creatinine were significantly (
P<0.05) increased while alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and urea decreased significantly (
P<0.05) in CY-treated group when compared with the control group. Kidneys were swollen grossly in treated broiler chicks. In liver, necrosis of hepatocytes, cytoplasmic vacuolation, bile duct hyperplasia and mononuclear cellular infiltration were observed. In kidneys, necrosis of tubular epithelial cells, cytoplasmic vacuolation, cellular infiltration and atrophy of glomeruli were observed. Sub-arachnoid space was much dilated in CY-treated broiler chicks. It can be concluded that CY induces biochemical and histopathological alterations in broilers chicks; however, these toxic effects can be ameliorated by Vit E or Se. Combination of Vit E and Se was more effective in ameliorating toxic effects of cypermethrin in broilers chicks.</description><identifier>ISSN: 0940-2993</identifier><identifier>EISSN: 1618-1433</identifier><identifier>DOI: 10.1016/j.etp.2009.06.004</identifier><identifier>PMID: 19581076</identifier><language>eng</language><publisher>Munich: Elsevier GmbH</publisher><subject>Animals ; Antioxidants - pharmacology ; Biochemical values ; Biological and medical sciences ; Blood Proteins - analysis ; Broiler chicks ; Chickens ; Cypermethrin ; Drug Synergism ; Insecticides - toxicity ; Investigative techniques, diagnostic techniques (general aspects) ; Kidney - drug effects ; Kidney - pathology ; Liver - drug effects ; Liver - pathology ; Medical sciences ; Necrosis ; Organ Size - drug effects ; Organ Specificity ; Pathological changes ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pyrethrins - toxicity ; Selenium ; Selenium - pharmacology ; Subarachnoid Space - drug effects ; Subarachnoid Space - pathology ; Toxicity Tests, Chronic ; Vitamin E ; Vitamin E - pharmacology</subject><ispartof>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2010-07, Vol.62 (4), p.441-450</ispartof><rights>2009 Elsevier GmbH</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-fd98081d09e40212f0c2746211524fd7e1dea48c7c0bb968ab68312342fe70853</citedby><cites>FETCH-LOGICAL-c414t-fd98081d09e40212f0c2746211524fd7e1dea48c7c0bb968ab68312342fe70853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0940299309001997$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23014192$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19581076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aslam, Faiza</creatorcontrib><creatorcontrib>Khan, Ahrar</creatorcontrib><creatorcontrib>Khan, Muhammad Zargham</creatorcontrib><creatorcontrib>Sharaf, Summaira</creatorcontrib><creatorcontrib>Gul, Shafia Tahseen</creatorcontrib><creatorcontrib>Saleemi, Muhammad Kashif</creatorcontrib><title>Toxico-pathological changes induced by cypermethrin in broiler chicks: Their attenuation with Vitamin E and selenium</title><title>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</title><addtitle>Exp Toxicol Pathol</addtitle><description>Ninety 1-day old broiler chicks of mixed gender (as hatched) procured from a local hatchery were randomly divided into five equal groups. All the treatments were given through crop tubing. Groups 1–4 received cypermethrin (CY) (600
mg
kg
−1
b. wt.) daily for 30 days. In addition to CY (group 1), groups 2–4 received Vit E (150
mg
kg
−1
b. wt.), Se (0.25
mg
kg
−1
b. wt.), and Vit E (150
mg
kg
−1
b. wt.)+Se (0.25
mg
kg
−1
b. wt.), respectively. Group 5 served as control andreceived normal saline (2
ml
kg
−1
b. wt.) for 30 days. Randomly selected six broiler chicks from each group were slaughtered at experimental days 10, 20 and 30 for the collection of serum/plasma and morbid tissues. Absolute organ weights were recorded. Total plasma proteins, fibrinogen and creatinine were significantly (
P<0.05) increased while alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and urea decreased significantly (
P<0.05) in CY-treated group when compared with the control group. Kidneys were swollen grossly in treated broiler chicks. In liver, necrosis of hepatocytes, cytoplasmic vacuolation, bile duct hyperplasia and mononuclear cellular infiltration were observed. In kidneys, necrosis of tubular epithelial cells, cytoplasmic vacuolation, cellular infiltration and atrophy of glomeruli were observed. Sub-arachnoid space was much dilated in CY-treated broiler chicks. It can be concluded that CY induces biochemical and histopathological alterations in broilers chicks; however, these toxic effects can be ameliorated by Vit E or Se. Combination of Vit E and Se was more effective in ameliorating toxic effects of cypermethrin in broilers chicks.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Biochemical values</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - analysis</subject><subject>Broiler chicks</subject><subject>Chickens</subject><subject>Cypermethrin</subject><subject>Drug Synergism</subject><subject>Insecticides - toxicity</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Medical sciences</subject><subject>Necrosis</subject><subject>Organ Size - drug effects</subject><subject>Organ Specificity</subject><subject>Pathological changes</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Pyrethrins - toxicity</subject><subject>Selenium</subject><subject>Selenium - pharmacology</subject><subject>Subarachnoid Space - drug effects</subject><subject>Subarachnoid Space - pathology</subject><subject>Toxicity Tests, Chronic</subject><subject>Vitamin E</subject><subject>Vitamin E - pharmacology</subject><issn>0940-2993</issn><issn>1618-1433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1v1DAQgGELgei28AO4IF8Qp4Sx43wYTlXVAlIlLgtXy3EmjZfEDrYD7L_H1a7gxsnS6JmR9RLyikHJgDXvDiWmteQAsoSmBBBPyI41rCuYqKqnZAdSQMGlrC7IZYwHAA6yZs_JBZN1x6BtdiTt_W9rfLHqNPnZP1ijZ2om7R4wUuuGzeBA-yM1xxXDgmkK1uU57YO3M4ZMrfke39P9hDZQnRK6TSfrHf1l00S_2aSXzG-pdgONOKOz2_KCPBv1HPHl-b0iX-9u9zefivsvHz_fXN8XRjCRinGQHXRsAIkCOOMjGN6KhjNWczEOLbIBtehMa6DvZdPpvukqxivBR2yhq6sr8vZ0dw3-x4YxqcVGg_OsHfotqrYWdZWLiCzZSZrgYww4qjXYRYejYqAeW6uDyq3VY2sFjcqt887r8_WtX3D4t3GOm8GbM9AxZx2DdsbGv45XwASTPLsPJ4e5xU-LQUVj0eXyNqBJavD2P9_4A0fmnPs</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Aslam, Faiza</creator><creator>Khan, Ahrar</creator><creator>Khan, Muhammad Zargham</creator><creator>Sharaf, Summaira</creator><creator>Gul, Shafia Tahseen</creator><creator>Saleemi, Muhammad Kashif</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>F1W</scope><scope>H98</scope><scope>L.G</scope></search><sort><creationdate>20100701</creationdate><title>Toxico-pathological changes induced by cypermethrin in broiler chicks: Their attenuation with Vitamin E and selenium</title><author>Aslam, Faiza ; Khan, Ahrar ; Khan, Muhammad Zargham ; Sharaf, Summaira ; Gul, Shafia Tahseen ; Saleemi, Muhammad Kashif</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-fd98081d09e40212f0c2746211524fd7e1dea48c7c0bb968ab68312342fe70853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Biochemical values</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - analysis</topic><topic>Broiler chicks</topic><topic>Chickens</topic><topic>Cypermethrin</topic><topic>Drug Synergism</topic><topic>Insecticides - toxicity</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Medical sciences</topic><topic>Necrosis</topic><topic>Organ Size - drug effects</topic><topic>Organ Specificity</topic><topic>Pathological changes</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Pyrethrins - toxicity</topic><topic>Selenium</topic><topic>Selenium - pharmacology</topic><topic>Subarachnoid Space - drug effects</topic><topic>Subarachnoid Space - pathology</topic><topic>Toxicity Tests, Chronic</topic><topic>Vitamin E</topic><topic>Vitamin E - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aslam, Faiza</creatorcontrib><creatorcontrib>Khan, Ahrar</creatorcontrib><creatorcontrib>Khan, Muhammad Zargham</creatorcontrib><creatorcontrib>Sharaf, Summaira</creatorcontrib><creatorcontrib>Gul, Shafia Tahseen</creatorcontrib><creatorcontrib>Saleemi, Muhammad Kashif</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aslam, Faiza</au><au>Khan, Ahrar</au><au>Khan, Muhammad Zargham</au><au>Sharaf, Summaira</au><au>Gul, Shafia Tahseen</au><au>Saleemi, Muhammad Kashif</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxico-pathological changes induced by cypermethrin in broiler chicks: Their attenuation with Vitamin E and selenium</atitle><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle><addtitle>Exp Toxicol Pathol</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>62</volume><issue>4</issue><spage>441</spage><epage>450</epage><pages>441-450</pages><issn>0940-2993</issn><eissn>1618-1433</eissn><abstract>Ninety 1-day old broiler chicks of mixed gender (as hatched) procured from a local hatchery were randomly divided into five equal groups. All the treatments were given through crop tubing. Groups 1–4 received cypermethrin (CY) (600
mg
kg
−1
b. wt.) daily for 30 days. In addition to CY (group 1), groups 2–4 received Vit E (150
mg
kg
−1
b. wt.), Se (0.25
mg
kg
−1
b. wt.), and Vit E (150
mg
kg
−1
b. wt.)+Se (0.25
mg
kg
−1
b. wt.), respectively. Group 5 served as control andreceived normal saline (2
ml
kg
−1
b. wt.) for 30 days. Randomly selected six broiler chicks from each group were slaughtered at experimental days 10, 20 and 30 for the collection of serum/plasma and morbid tissues. Absolute organ weights were recorded. Total plasma proteins, fibrinogen and creatinine were significantly (
P<0.05) increased while alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and urea decreased significantly (
P<0.05) in CY-treated group when compared with the control group. Kidneys were swollen grossly in treated broiler chicks. In liver, necrosis of hepatocytes, cytoplasmic vacuolation, bile duct hyperplasia and mononuclear cellular infiltration were observed. In kidneys, necrosis of tubular epithelial cells, cytoplasmic vacuolation, cellular infiltration and atrophy of glomeruli were observed. Sub-arachnoid space was much dilated in CY-treated broiler chicks. It can be concluded that CY induces biochemical and histopathological alterations in broilers chicks; however, these toxic effects can be ameliorated by Vit E or Se. Combination of Vit E and Se was more effective in ameliorating toxic effects of cypermethrin in broilers chicks.</abstract><cop>Munich</cop><pub>Elsevier GmbH</pub><pmid>19581076</pmid><doi>10.1016/j.etp.2009.06.004</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0940-2993 |
| ispartof | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2010-07, Vol.62 (4), p.441-450 |
| issn | 0940-2993 1618-1433 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_754539514 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antioxidants - pharmacology Biochemical values Biological and medical sciences Blood Proteins - analysis Broiler chicks Chickens Cypermethrin Drug Synergism Insecticides - toxicity Investigative techniques, diagnostic techniques (general aspects) Kidney - drug effects Kidney - pathology Liver - drug effects Liver - pathology Medical sciences Necrosis Organ Size - drug effects Organ Specificity Pathological changes Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pyrethrins - toxicity Selenium Selenium - pharmacology Subarachnoid Space - drug effects Subarachnoid Space - pathology Toxicity Tests, Chronic Vitamin E Vitamin E - pharmacology |
| title | Toxico-pathological changes induced by cypermethrin in broiler chicks: Their attenuation with Vitamin E and selenium |
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