Flower Forms an Extracellular Code that Reveals the Fitness of a Cell to its Neighbors in Drosophila
Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of Drosophila wing imaginal discs distinguish “winners” from “losers” during cell competition. Using genomic and functional assays, we have identified several factors implicated in the...
Gespeichert in:
| Veröffentlicht in: | Developmental cell 2010-06, Vol.18 (6), p.985-998 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 998 |
|---|---|
| container_issue | 6 |
| container_start_page | 985 |
| container_title | Developmental cell |
| container_volume | 18 |
| creator | Rhiner, Christa López-Gay, Jesús M. Soldini, Davide Casas-Tinto, Sergio Martín, Francisco A. Lombardía, Luis Moreno, Eduardo |
| description | Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of
Drosophila wing imaginal discs distinguish “winners” from “losers” during cell competition. Using genomic and functional assays, we have identified several factors implicated in the process, including Flower (Fwe), a cell membrane protein conserved in multicellular animals. Our results suggest that Fwe is a component of the cell competition response that is required and sufficient to label cells as “winners” or “losers.” In
Drosophila, the
fwe locus produces three isoforms,
fwe
ubi, fwe
Lose-A
, and
fwe
Lose-B
. Basal levels of
fwe
ubi
are constantly produced. During competition, the
fwe
Lose
isoforms are upregulated in prospective loser cells. Cell-cell comparison of relative
fwe
Lose
and
fwe
ubi
levels ultimately determines which cell undergoes apoptosis. This “extracellular code” may constitute an ancient mechanism to terminate competitive conflicts among cells.
► Flower (Fwe) is a conserved cell membrane protein ► During cell competition in fly imaginal discs, Fwe determines “winners” and “losers” ► A ubiquitous Fwe isoform promotes cell survival ► Fwe isoforms produced only by “loser” cells induce cell death |
| doi_str_mv | 10.1016/j.devcel.2010.05.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_754539124</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1534580710002182</els_id><sourcerecordid>754539124</sourcerecordid><originalsourceid>FETCH-LOGICAL-c469t-dd12f737285d208f8009045e0fcb823d33587818f8ad756938180540d67fe8d43</originalsourceid><addsrcrecordid>eNqNkUGvEyEQxzdG43s-_QbGcDGetg6wLOzFxNRXNXnRxOiZUJi1NNulAq367Z2mVW_G0wzw-88w82-apxwWHHj_crsIePQ4LQTQFagFhXvNNTfatFwpfp9yJbtWGdBXzaNStkAybuBhcyWgFxoMXDdhNaXvmNkq5V1hbma3P2p2VHY6TC6zZQrI6sZV9gmP6KZCB2SrWGcshaWRObYkltXEYi3sA8avm3XKhcWZvcmppP0mTu5x82AkLT65xJvmy-r28_Jde_fx7fvl67vWd_1Q2xC4GLXUwqggwIwGYIBOIYx-bYQMUioajtODC1r1g6QcVAeh1yOa0Mmb5sW57j6nbwcs1e5iOc3iZkyHYrXqlBy4-A9SysEYPmgiuzPpaZyScbT7HHcu_7Qc7MkIu7VnI-zJCAvKUiDZs0uDw3qH4Y_o9-YJeH4BXPFuGrObfSx_OTEIoQdD3Kszh7S4Y8Rsi484ewwxo682pPjvn_wCsf-mIA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733988197</pqid></control><display><type>article</type><title>Flower Forms an Extracellular Code that Reveals the Fitness of a Cell to its Neighbors in Drosophila</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Rhiner, Christa ; López-Gay, Jesús M. ; Soldini, Davide ; Casas-Tinto, Sergio ; Martín, Francisco A. ; Lombardía, Luis ; Moreno, Eduardo</creator><creatorcontrib>Rhiner, Christa ; López-Gay, Jesús M. ; Soldini, Davide ; Casas-Tinto, Sergio ; Martín, Francisco A. ; Lombardía, Luis ; Moreno, Eduardo</creatorcontrib><description>Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of
Drosophila wing imaginal discs distinguish “winners” from “losers” during cell competition. Using genomic and functional assays, we have identified several factors implicated in the process, including Flower (Fwe), a cell membrane protein conserved in multicellular animals. Our results suggest that Fwe is a component of the cell competition response that is required and sufficient to label cells as “winners” or “losers.” In
Drosophila, the
fwe locus produces three isoforms,
fwe
ubi, fwe
Lose-A
, and
fwe
Lose-B
. Basal levels of
fwe
ubi
are constantly produced. During competition, the
fwe
Lose
isoforms are upregulated in prospective loser cells. Cell-cell comparison of relative
fwe
Lose
and
fwe
ubi
levels ultimately determines which cell undergoes apoptosis. This “extracellular code” may constitute an ancient mechanism to terminate competitive conflicts among cells.
► Flower (Fwe) is a conserved cell membrane protein ► During cell competition in fly imaginal discs, Fwe determines “winners” and “losers” ► A ubiquitous Fwe isoform promotes cell survival ► Fwe isoforms produced only by “loser” cells induce cell death</description><identifier>ISSN: 1534-5807</identifier><identifier>EISSN: 1878-1551</identifier><identifier>DOI: 10.1016/j.devcel.2010.05.010</identifier><identifier>PMID: 20627080</identifier><language>eng</language><publisher>Cambridge, MA: Elsevier Inc</publisher><subject>Animals ; Apoptosis ; Apoptosis - physiology ; Biological and medical sciences ; Calcium Channels - genetics ; Calcium Channels - metabolism ; Cell Communication - physiology ; Cell Differentiation - physiology ; Cell differentiation, maturation, development, hematopoiesis ; Cell Membrane - genetics ; Cell Membrane - metabolism ; Cell physiology ; Cell Survival - physiology ; CELLBIO ; DEVBIO ; Drosophila ; Drosophila melanogaster - cytology ; Drosophila melanogaster - embryology ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Extracellular Space - genetics ; Extracellular Space - metabolism ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Developmental - physiology ; Molecular and cellular biology ; Organogenesis - physiology ; Protein Isoforms - genetics ; Protein Isoforms - metabolism ; SIGNALING ; Up-Regulation - physiology ; Wings, Animal - cytology ; Wings, Animal - embryology</subject><ispartof>Developmental cell, 2010-06, Vol.18 (6), p.985-998</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-dd12f737285d208f8009045e0fcb823d33587818f8ad756938180540d67fe8d43</citedby><cites>FETCH-LOGICAL-c469t-dd12f737285d208f8009045e0fcb823d33587818f8ad756938180540d67fe8d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1534580710002182$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22922798$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20627080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rhiner, Christa</creatorcontrib><creatorcontrib>López-Gay, Jesús M.</creatorcontrib><creatorcontrib>Soldini, Davide</creatorcontrib><creatorcontrib>Casas-Tinto, Sergio</creatorcontrib><creatorcontrib>Martín, Francisco A.</creatorcontrib><creatorcontrib>Lombardía, Luis</creatorcontrib><creatorcontrib>Moreno, Eduardo</creatorcontrib><title>Flower Forms an Extracellular Code that Reveals the Fitness of a Cell to its Neighbors in Drosophila</title><title>Developmental cell</title><addtitle>Dev Cell</addtitle><description>Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of
Drosophila wing imaginal discs distinguish “winners” from “losers” during cell competition. Using genomic and functional assays, we have identified several factors implicated in the process, including Flower (Fwe), a cell membrane protein conserved in multicellular animals. Our results suggest that Fwe is a component of the cell competition response that is required and sufficient to label cells as “winners” or “losers.” In
Drosophila, the
fwe locus produces three isoforms,
fwe
ubi, fwe
Lose-A
, and
fwe
Lose-B
. Basal levels of
fwe
ubi
are constantly produced. During competition, the
fwe
Lose
isoforms are upregulated in prospective loser cells. Cell-cell comparison of relative
fwe
Lose
and
fwe
ubi
levels ultimately determines which cell undergoes apoptosis. This “extracellular code” may constitute an ancient mechanism to terminate competitive conflicts among cells.
► Flower (Fwe) is a conserved cell membrane protein ► During cell competition in fly imaginal discs, Fwe determines “winners” and “losers” ► A ubiquitous Fwe isoform promotes cell survival ► Fwe isoforms produced only by “loser” cells induce cell death</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - physiology</subject><subject>Biological and medical sciences</subject><subject>Calcium Channels - genetics</subject><subject>Calcium Channels - metabolism</subject><subject>Cell Communication - physiology</subject><subject>Cell Differentiation - physiology</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell Membrane - genetics</subject><subject>Cell Membrane - metabolism</subject><subject>Cell physiology</subject><subject>Cell Survival - physiology</subject><subject>CELLBIO</subject><subject>DEVBIO</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - cytology</subject><subject>Drosophila melanogaster - embryology</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Extracellular Space - genetics</subject><subject>Extracellular Space - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>Molecular and cellular biology</subject><subject>Organogenesis - physiology</subject><subject>Protein Isoforms - genetics</subject><subject>Protein Isoforms - metabolism</subject><subject>SIGNALING</subject><subject>Up-Regulation - physiology</subject><subject>Wings, Animal - cytology</subject><subject>Wings, Animal - embryology</subject><issn>1534-5807</issn><issn>1878-1551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUGvEyEQxzdG43s-_QbGcDGetg6wLOzFxNRXNXnRxOiZUJi1NNulAq367Z2mVW_G0wzw-88w82-apxwWHHj_crsIePQ4LQTQFagFhXvNNTfatFwpfp9yJbtWGdBXzaNStkAybuBhcyWgFxoMXDdhNaXvmNkq5V1hbma3P2p2VHY6TC6zZQrI6sZV9gmP6KZCB2SrWGcshaWRObYkltXEYi3sA8avm3XKhcWZvcmppP0mTu5x82AkLT65xJvmy-r28_Jde_fx7fvl67vWd_1Q2xC4GLXUwqggwIwGYIBOIYx-bYQMUioajtODC1r1g6QcVAeh1yOa0Mmb5sW57j6nbwcs1e5iOc3iZkyHYrXqlBy4-A9SysEYPmgiuzPpaZyScbT7HHcu_7Qc7MkIu7VnI-zJCAvKUiDZs0uDw3qH4Y_o9-YJeH4BXPFuGrObfSx_OTEIoQdD3Kszh7S4Y8Rsi484ewwxo682pPjvn_wCsf-mIA</recordid><startdate>20100615</startdate><enddate>20100615</enddate><creator>Rhiner, Christa</creator><creator>López-Gay, Jesús M.</creator><creator>Soldini, Davide</creator><creator>Casas-Tinto, Sergio</creator><creator>Martín, Francisco A.</creator><creator>Lombardía, Luis</creator><creator>Moreno, Eduardo</creator><general>Elsevier Inc</general><general>Cell Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SS</scope></search><sort><creationdate>20100615</creationdate><title>Flower Forms an Extracellular Code that Reveals the Fitness of a Cell to its Neighbors in Drosophila</title><author>Rhiner, Christa ; López-Gay, Jesús M. ; Soldini, Davide ; Casas-Tinto, Sergio ; Martín, Francisco A. ; Lombardía, Luis ; Moreno, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-dd12f737285d208f8009045e0fcb823d33587818f8ad756938180540d67fe8d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - physiology</topic><topic>Biological and medical sciences</topic><topic>Calcium Channels - genetics</topic><topic>Calcium Channels - metabolism</topic><topic>Cell Communication - physiology</topic><topic>Cell Differentiation - physiology</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell Membrane - genetics</topic><topic>Cell Membrane - metabolism</topic><topic>Cell physiology</topic><topic>Cell Survival - physiology</topic><topic>CELLBIO</topic><topic>DEVBIO</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - cytology</topic><topic>Drosophila melanogaster - embryology</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Extracellular Space - genetics</topic><topic>Extracellular Space - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Developmental - physiology</topic><topic>Molecular and cellular biology</topic><topic>Organogenesis - physiology</topic><topic>Protein Isoforms - genetics</topic><topic>Protein Isoforms - metabolism</topic><topic>SIGNALING</topic><topic>Up-Regulation - physiology</topic><topic>Wings, Animal - cytology</topic><topic>Wings, Animal - embryology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rhiner, Christa</creatorcontrib><creatorcontrib>López-Gay, Jesús M.</creatorcontrib><creatorcontrib>Soldini, Davide</creatorcontrib><creatorcontrib>Casas-Tinto, Sergio</creatorcontrib><creatorcontrib>Martín, Francisco A.</creatorcontrib><creatorcontrib>Lombardía, Luis</creatorcontrib><creatorcontrib>Moreno, Eduardo</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Entomology Abstracts (Full archive)</collection><jtitle>Developmental cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rhiner, Christa</au><au>López-Gay, Jesús M.</au><au>Soldini, Davide</au><au>Casas-Tinto, Sergio</au><au>Martín, Francisco A.</au><au>Lombardía, Luis</au><au>Moreno, Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flower Forms an Extracellular Code that Reveals the Fitness of a Cell to its Neighbors in Drosophila</atitle><jtitle>Developmental cell</jtitle><addtitle>Dev Cell</addtitle><date>2010-06-15</date><risdate>2010</risdate><volume>18</volume><issue>6</issue><spage>985</spage><epage>998</epage><pages>985-998</pages><issn>1534-5807</issn><eissn>1878-1551</eissn><abstract>Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of
Drosophila wing imaginal discs distinguish “winners” from “losers” during cell competition. Using genomic and functional assays, we have identified several factors implicated in the process, including Flower (Fwe), a cell membrane protein conserved in multicellular animals. Our results suggest that Fwe is a component of the cell competition response that is required and sufficient to label cells as “winners” or “losers.” In
Drosophila, the
fwe locus produces three isoforms,
fwe
ubi, fwe
Lose-A
, and
fwe
Lose-B
. Basal levels of
fwe
ubi
are constantly produced. During competition, the
fwe
Lose
isoforms are upregulated in prospective loser cells. Cell-cell comparison of relative
fwe
Lose
and
fwe
ubi
levels ultimately determines which cell undergoes apoptosis. This “extracellular code” may constitute an ancient mechanism to terminate competitive conflicts among cells.
► Flower (Fwe) is a conserved cell membrane protein ► During cell competition in fly imaginal discs, Fwe determines “winners” and “losers” ► A ubiquitous Fwe isoform promotes cell survival ► Fwe isoforms produced only by “loser” cells induce cell death</abstract><cop>Cambridge, MA</cop><pub>Elsevier Inc</pub><pmid>20627080</pmid><doi>10.1016/j.devcel.2010.05.010</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1534-5807 |
| ispartof | Developmental cell, 2010-06, Vol.18 (6), p.985-998 |
| issn | 1534-5807 1878-1551 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_754539124 |
| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Apoptosis Apoptosis - physiology Biological and medical sciences Calcium Channels - genetics Calcium Channels - metabolism Cell Communication - physiology Cell Differentiation - physiology Cell differentiation, maturation, development, hematopoiesis Cell Membrane - genetics Cell Membrane - metabolism Cell physiology Cell Survival - physiology CELLBIO DEVBIO Drosophila Drosophila melanogaster - cytology Drosophila melanogaster - embryology Drosophila Proteins - genetics Drosophila Proteins - metabolism Extracellular Space - genetics Extracellular Space - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - physiology Molecular and cellular biology Organogenesis - physiology Protein Isoforms - genetics Protein Isoforms - metabolism SIGNALING Up-Regulation - physiology Wings, Animal - cytology Wings, Animal - embryology |
| title | Flower Forms an Extracellular Code that Reveals the Fitness of a Cell to its Neighbors in Drosophila |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T16%3A12%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Flower%20Forms%20an%20Extracellular%20Code%20that%20Reveals%20the%20Fitness%20of%20a%20Cell%20to%20its%20Neighbors%20in%20Drosophila&rft.jtitle=Developmental%20cell&rft.au=Rhiner,%20Christa&rft.date=2010-06-15&rft.volume=18&rft.issue=6&rft.spage=985&rft.epage=998&rft.pages=985-998&rft.issn=1534-5807&rft.eissn=1878-1551&rft_id=info:doi/10.1016/j.devcel.2010.05.010&rft_dat=%3Cproquest_cross%3E754539124%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733988197&rft_id=info:pmid/20627080&rft_els_id=S1534580710002182&rfr_iscdi=true |