Development of a multi-scale finite element model of the osteoporotic lumbar vertebral body for the investigation of apparent level vertebra mechanics and micro-level trabecular mechanics
Abstract Osteoporotic spinal fractures are a major concern in ageing Western societies. This study develops a multi-scale finite element (FE) model of the osteoporotic lumbar vertebral body to study the mechanics of vertebral compression fracture at both the apparent (whole vertebral body) and micro...
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| Veröffentlicht in: | Medical engineering & physics 2010-07, Vol.32 (6), p.653-661 |
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| creator | McDonald, K Little, J Pearcy, M Adam, C |
| description | Abstract Osteoporotic spinal fractures are a major concern in ageing Western societies. This study develops a multi-scale finite element (FE) model of the osteoporotic lumbar vertebral body to study the mechanics of vertebral compression fracture at both the apparent (whole vertebral body) and micro-structural (internal trabecular bone core) levels. Model predictions were verified against experimental data, and found to provide a reasonably good representation of the mechanics of the osteoporotic vertebral body. This novel modelling methodology will allow detailed investigation of how trabecular bone loss in osteoporosis affects vertebral stiffness and strength in the lumbar spine. |
| doi_str_mv | 10.1016/j.medengphy.2010.04.006 |
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This study develops a multi-scale finite element (FE) model of the osteoporotic lumbar vertebral body to study the mechanics of vertebral compression fracture at both the apparent (whole vertebral body) and micro-structural (internal trabecular bone core) levels. Model predictions were verified against experimental data, and found to provide a reasonably good representation of the mechanics of the osteoporotic vertebral body. This novel modelling methodology will allow detailed investigation of how trabecular bone loss in osteoporosis affects vertebral stiffness and strength in the lumbar spine.</description><identifier>ISSN: 1350-4533</identifier><identifier>EISSN: 1873-4030</identifier><identifier>DOI: 10.1016/j.medengphy.2010.04.006</identifier><identifier>PMID: 20439162</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Aged ; Biological and medical sciences ; Biomechanical Phenomena ; Computerized, statistical medical data processing and models in biomedicine ; Diseases of the osteoarticular system ; Female ; Finite element ; Finite Element Analysis ; Fractures, Bone - complications ; Fractures, Bone - physiopathology ; Humans ; Injuries of the limb. Injuries of the spine ; Lumbar Vertebrae - injuries ; Lumbar Vertebrae - physiopathology ; Male ; Medical sciences ; Middle Aged ; Models and simulation ; Models, Biological ; Multi-scale model ; Osteoporosis ; Osteoporosis - complications ; Osteoporosis - physiopathology ; Osteoporosis. Osteomalacia. Paget disease ; Radiology ; Stress, Mechanical ; Trabecular mechanics ; Traumas. Diseases due to physical agents ; Vertebral compression fracture ; Vertebral mechanics</subject><ispartof>Medical engineering & physics, 2010-07, Vol.32 (6), p.653-661</ispartof><rights>IPEM</rights><rights>2010 IPEM</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 IPEM. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-a17b5b44823b73f706a6dda7d3e34c7afc19cb95b912d38b11b7ade97e707c0b3</citedby><cites>FETCH-LOGICAL-c536t-a17b5b44823b73f706a6dda7d3e34c7afc19cb95b912d38b11b7ade97e707c0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1350453310000809$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22995920$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20439162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McDonald, K</creatorcontrib><creatorcontrib>Little, J</creatorcontrib><creatorcontrib>Pearcy, M</creatorcontrib><creatorcontrib>Adam, C</creatorcontrib><title>Development of a multi-scale finite element model of the osteoporotic lumbar vertebral body for the investigation of apparent level vertebra mechanics and micro-level trabecular mechanics</title><title>Medical engineering & physics</title><addtitle>Med Eng Phys</addtitle><description>Abstract Osteoporotic spinal fractures are a major concern in ageing Western societies. This study develops a multi-scale finite element (FE) model of the osteoporotic lumbar vertebral body to study the mechanics of vertebral compression fracture at both the apparent (whole vertebral body) and micro-structural (internal trabecular bone core) levels. Model predictions were verified against experimental data, and found to provide a reasonably good representation of the mechanics of the osteoporotic vertebral body. This novel modelling methodology will allow detailed investigation of how trabecular bone loss in osteoporosis affects vertebral stiffness and strength in the lumbar spine.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Computerized, statistical medical data processing and models in biomedicine</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Finite element</subject><subject>Finite Element Analysis</subject><subject>Fractures, Bone - complications</subject><subject>Fractures, Bone - physiopathology</subject><subject>Humans</subject><subject>Injuries of the limb. Injuries of the spine</subject><subject>Lumbar Vertebrae - injuries</subject><subject>Lumbar Vertebrae - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Models and simulation</subject><subject>Models, Biological</subject><subject>Multi-scale model</subject><subject>Osteoporosis</subject><subject>Osteoporosis - complications</subject><subject>Osteoporosis - physiopathology</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Radiology</subject><subject>Stress, Mechanical</subject><subject>Trabecular mechanics</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Vertebral compression fracture</subject><subject>Vertebral mechanics</subject><issn>1350-4533</issn><issn>1873-4030</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks-O0zAQxiMEYv_AK4AviFPKOE7i-oK0WlhAWokDcLZsZ7J1ceJgO5X6bLwcTluKxAVOtuzfzDcz3xTFSworCrR9s10N2OH4MG32qwryK9QrgPZRcUnXnJU1MHic76yBsm4YuyiuYtwCQF237GlxUUHNBG2ry-LnO9yh89OAYyK-J4oMs0u2jEY5JL0dbUKCDg__g-_QLVTaIPExoZ988Mka4uZBq0B2GBLqoBzRvtuT3ocDascdxmQfVLJ-PKhMkwpLRreon8PIgGajRmsiUWNHBmuCL49ICkqjmV0WOUPPiie9chGfn87r4tvd-6-3H8v7zx8-3d7cl6ZhbSoV5brRdb2umOas59CqtusU7xiy2nDVGyqMFo0WtOrYWlOquepQcOTADWh2Xbw-5p2C_zHnTuRgo0Hn1Ih-jpI3ecZrweHfJGOiBS5oJvmRzC3GGLCXU7CDCntJQS4Wy608WywXiyXUMlucI1-cNGadiXPcb08z8OoEqMXFPqjR2PiHq4RoRLUUe3PkMM9uZzHIaCyOBjsb0CTZefsfxbz9K4dxeWey7HfcY9z6OYzZGkllrCTIL8tGLgtJ8y7CGgT7BRYi4xA</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>McDonald, K</creator><creator>Little, J</creator><creator>Pearcy, M</creator><creator>Adam, C</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20100701</creationdate><title>Development of a multi-scale finite element model of the osteoporotic lumbar vertebral body for the investigation of apparent level vertebra mechanics and micro-level trabecular mechanics</title><author>McDonald, K ; Little, J ; Pearcy, M ; Adam, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-a17b5b44823b73f706a6dda7d3e34c7afc19cb95b912d38b11b7ade97e707c0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Computerized, statistical medical data processing and models in biomedicine</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Finite element</topic><topic>Finite Element Analysis</topic><topic>Fractures, Bone - complications</topic><topic>Fractures, Bone - physiopathology</topic><topic>Humans</topic><topic>Injuries of the limb. Injuries of the spine</topic><topic>Lumbar Vertebrae - injuries</topic><topic>Lumbar Vertebrae - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Models and simulation</topic><topic>Models, Biological</topic><topic>Multi-scale model</topic><topic>Osteoporosis</topic><topic>Osteoporosis - complications</topic><topic>Osteoporosis - physiopathology</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Radiology</topic><topic>Stress, Mechanical</topic><topic>Trabecular mechanics</topic><topic>Traumas. 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| subjects | Aged Biological and medical sciences Biomechanical Phenomena Computerized, statistical medical data processing and models in biomedicine Diseases of the osteoarticular system Female Finite element Finite Element Analysis Fractures, Bone - complications Fractures, Bone - physiopathology Humans Injuries of the limb. Injuries of the spine Lumbar Vertebrae - injuries Lumbar Vertebrae - physiopathology Male Medical sciences Middle Aged Models and simulation Models, Biological Multi-scale model Osteoporosis Osteoporosis - complications Osteoporosis - physiopathology Osteoporosis. Osteomalacia. Paget disease Radiology Stress, Mechanical Trabecular mechanics Traumas. Diseases due to physical agents Vertebral compression fracture Vertebral mechanics |
| title | Development of a multi-scale finite element model of the osteoporotic lumbar vertebral body for the investigation of apparent level vertebra mechanics and micro-level trabecular mechanics |
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