In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F

Domoic acid and its isomers are produced via algal blooms and are found in high concentrations in shellfish. Here, we assessed the acute seizurogenic potencies of isomers-D, -E and -F and their binding affinities at heterogeneous populations of KA receptors from rat cerebrum. In addition, binding af...

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Veröffentlicht in:	Neuropharmacology 2010-09, Vol.59 (3), p.129-138
Hauptverfasser:	Sawant, P.M., Tyndall, J.D.A., Holland, P.T., Peake, B.M., Mountfort, D.O., Kerr, D.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute preconditioning alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacokinetics AMPA receptor affinity Analysis of Variance Animals Binding, Competitive - drug effects Disease Models, Animal Dose-Response Relationship, Drug Drug Tolerance GluK2 Kainate Receptor GluK2 receptor Hippocampus Hippocampus - ultrastructure Isodomoic acid Isomerism KA receptor affinity Kainic Acid - analogs & derivatives Kainic Acid - chemistry Kainic Acid - pharmacokinetics Kainic Acid - toxicity Male Models, Molecular Molecular Conformation Molecular modeling Neuromuscular Depolarizing Agents - chemistry Neuromuscular Depolarizing Agents - pharmacokinetics Neuromuscular Depolarizing Agents - toxicity Protein Binding - drug effects Rats Rats, Sprague-Dawley Receptors, Kainic Acid - drug effects Seizure Seizures - chemically induced Synaptosomes - drug effects Tritium - pharmacokinetics
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