SIRT1 and p53, effect on cancer, senescence and beyond
NAD +-dependent Class III histone deacetylase SIRT1 is a multiple function protein critically involved in stress responses, cellular metabolism and aging through deacetylating a variety of substrates including p53, forkhead-box transcription factors, PGC-1α, NF-κB, Ku70 and histones. The first disco...
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| Veröffentlicht in: | Biochimica et biophysica acta 2010-08, Vol.1804 (8), p.1684-1689 |
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| container_title | Biochimica et biophysica acta |
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| creator | Yi, Jingjie Luo, Jianyuan |
| description | NAD
+-dependent Class III histone deacetylase SIRT1 is a multiple function protein critically involved in stress responses, cellular metabolism and aging through deacetylating a variety of substrates including p53, forkhead-box transcription factors, PGC-1α, NF-κB, Ku70 and histones. The first discovered non-histone target of SIRT1, p53, is suggested to play a central role in SIRT1-mediated functions in tumorigenesis and senescence. SIRT1 was originally considered to be a potential tumor promoter since it negatively regulates the tumor suppressor p53 and other tumor suppressors. There is new evidence that SIRT1 acts as a tumor suppressor based on its role in negatively regulating β-catenin and survivin. This review provides an overview of current knowledge of SIRT1-p53 signaling and controversies regarding the functions of SIRT1 in tumorigenesis. |
| doi_str_mv | 10.1016/j.bbapap.2010.05.002 |
| format | Article |
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+-dependent Class III histone deacetylase SIRT1 is a multiple function protein critically involved in stress responses, cellular metabolism and aging through deacetylating a variety of substrates including p53, forkhead-box transcription factors, PGC-1α, NF-κB, Ku70 and histones. The first discovered non-histone target of SIRT1, p53, is suggested to play a central role in SIRT1-mediated functions in tumorigenesis and senescence. SIRT1 was originally considered to be a potential tumor promoter since it negatively regulates the tumor suppressor p53 and other tumor suppressors. There is new evidence that SIRT1 acts as a tumor suppressor based on its role in negatively regulating β-catenin and survivin. 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| ispartof | Biochimica et biophysica acta, 2010-08, Vol.1804 (8), p.1684-1689 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylation Aging - metabolism Animals Apoptosis Cancer Cellular Senescence Deacetylation Humans Mice Models, Biological Neoplasms - etiology Neoplasms - metabolism Nerve Degeneration - etiology Nerve Degeneration - metabolism Oxidative Stress p53 Senescence Signal Transduction SIRT1 Sirtuin 1 - metabolism Tumor Suppressor Protein p53 - metabolism |
| title | SIRT1 and p53, effect on cancer, senescence and beyond |
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