Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

Our understanding of secondary metabolite production in bacteria has been shaped primarily by studies of attached varieties such as symbionts, pathogens, and soil bacteria. Here we show that a strain of the single-celled, planktonic marine cyanobacterium PROCHLOROCOCCUS:which conducts a sizable frac...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-06, Vol.107 (23), p.10430-10435
Hauptverfasser:	Li, Bo, Sher, Daniel, Kelly, Libusha, Shi, Yanxiang, Huang, Katherine, Knerr, Patrick J, Joewono, Ike, Rusch, Doug, Chisholm, Sallie W, van der Donk, Wilfred A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacteria Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriocins Biocatalysis Biological Sciences Biosynthesis Conserved Sequence Cyanobacteria Cyclization Dehydration Enzymes Gene expression Genetic diversity Genome, Bacterial Genomes Mathematical rings Metabolites Molecular Sequence Data Multigene Family Oceans Peptides Peptides, Cyclic - biosynthesis Phytoplankton - chemistry Phytoplankton - genetics Phytoplankton - metabolism Prochlorococcus Prochlorococcus - chemistry Prochlorococcus - genetics Prochlorococcus - metabolism Sequence Alignment Topology
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