Protein Kinase C Isoforms I and I[sup1 Mediate Collagenase Expression and Cartilage Destruction via STAT3- and ERK-dependent c-fos Induction

The protein kinase C (PKC) signaling pathway is a major regulator of cellular functions and is implicated in pathologies involving extracellular matrix remodeling. Inflammatory joint disease is characterized by excessive extracellular matrix catabolism, and here we assess the role of PKC in the indu...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2010-07, Vol.285 (29), p.22414-22425
Hauptverfasser:	Litherland, Gary J, Elias, Martina S, Hui, Wang, Macdonald, Christopher D, Catterall, Jonathon B, Barter, Matt J, Farren, Matthew J, Jefferson, Matthew, Rowan, Andrew D
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!