Spectrum of Cardiac Involvement in Neonatal Lupus
'Neonatal' lupus erythematosus (NLE) describes a clinical spectrum of cardiac and non-cardiac abnormalities observed in neonates and foetuses whose mothers have the auto-antibodies anti-SSA/Ro (anti-Ro) and anti-SSB/La (anti-La). Of the cardiac abnormalities, congenital AVB is the most com...
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| Veröffentlicht in: | Scandinavian journal of immunology 2010-09, Vol.72 (3), p.189-197 |
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| description | 'Neonatal' lupus erythematosus (NLE) describes a clinical spectrum of cardiac and non-cardiac abnormalities observed in neonates and foetuses whose mothers have the auto-antibodies anti-SSA/Ro (anti-Ro) and anti-SSB/La (anti-La). Of the cardiac abnormalities, congenital AVB is the most common cardiovascular abnormality found in affected foetuses and infants. Many other cardiovascular manifestations of NLE have been more recently recognized including atrial and ventricular arrhythmias and other conduction abnormalities, myocarditis, cardiomyopathy often with endocardiofibroelastosis and structural heart disease, particularly valvar lesions. In this report, the spectrum of cardiovascular manifestations observed in foetuses and infants with NLE are reviewed and the pathogenesis, diagnosis and clinical outcomes are briefly discussed. |
| doi_str_mv | 10.1111/j.1365-3083.2010.02437.x |
| format | Article |
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Of the cardiac abnormalities, congenital AVB is the most common cardiovascular abnormality found in affected foetuses and infants. Many other cardiovascular manifestations of NLE have been more recently recognized including atrial and ventricular arrhythmias and other conduction abnormalities, myocarditis, cardiomyopathy often with endocardiofibroelastosis and structural heart disease, particularly valvar lesions. In this report, the spectrum of cardiovascular manifestations observed in foetuses and infants with NLE are reviewed and the pathogenesis, diagnosis and clinical outcomes are briefly discussed.</description><identifier>ISSN: 0300-9475</identifier><identifier>EISSN: 1365-3083</identifier><identifier>DOI: 10.1111/j.1365-3083.2010.02437.x</identifier><identifier>PMID: 20696015</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Arrhythmias, Cardiac - congenital ; Arrhythmias, Cardiac - etiology ; Arrhythmias, Cardiac - pathology ; Arrhythmias, Cardiac - physiopathology ; Atrioventricular Block - congenital ; Atrioventricular Block - etiology ; Atrioventricular Block - immunology ; Atrioventricular Block - pathology ; Atrioventricular Block - physiopathology ; Cardiomyopathies - congenital ; Cardiomyopathies - etiology ; Cardiomyopathies - immunology ; Cardiomyopathies - pathology ; Cardiomyopathies - physiopathology ; Heart Diseases - congenital ; Heart Diseases - etiology ; Heart Diseases - immunology ; Heart Diseases - pathology ; Heart Diseases - physiopathology ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases - etiology ; Infant, Newborn, Diseases - immunology ; Infant, Newborn, Diseases - pathology ; Infant, Newborn, Diseases - physiopathology ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - congenital ; Lupus Erythematosus, Systemic - immunology</subject><ispartof>Scandinavian journal of immunology, 2010-09, Vol.72 (3), p.189-197</ispartof><rights>2010 The Authors. 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Al Rajaa, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3757-4688fd41ff62719321a20ecafebc9b5a8c602ace822b8450d3acbaecf8c274a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Arrhythmias, Cardiac - congenital</topic><topic>Arrhythmias, Cardiac - etiology</topic><topic>Arrhythmias, Cardiac - pathology</topic><topic>Arrhythmias, Cardiac - physiopathology</topic><topic>Atrioventricular Block - congenital</topic><topic>Atrioventricular Block - etiology</topic><topic>Atrioventricular Block - immunology</topic><topic>Atrioventricular Block - pathology</topic><topic>Atrioventricular Block - physiopathology</topic><topic>Cardiomyopathies - congenital</topic><topic>Cardiomyopathies - etiology</topic><topic>Cardiomyopathies - immunology</topic><topic>Cardiomyopathies - pathology</topic><topic>Cardiomyopathies - physiopathology</topic><topic>Heart Diseases - congenital</topic><topic>Heart Diseases - etiology</topic><topic>Heart Diseases - immunology</topic><topic>Heart Diseases - pathology</topic><topic>Heart Diseases - physiopathology</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Newborn, Diseases - etiology</topic><topic>Infant, Newborn, Diseases - immunology</topic><topic>Infant, Newborn, Diseases - pathology</topic><topic>Infant, Newborn, Diseases - physiopathology</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - congenital</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hornberger, L.K</creatorcontrib><creatorcontrib>Al Rajaa, N</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Scandinavian journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hornberger, L.K</au><au>Al Rajaa, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spectrum of Cardiac Involvement in Neonatal Lupus</atitle><jtitle>Scandinavian journal of immunology</jtitle><addtitle>Scand J Immunol</addtitle><date>2010-09</date><risdate>2010</risdate><volume>72</volume><issue>3</issue><spage>189</spage><epage>197</epage><pages>189-197</pages><issn>0300-9475</issn><eissn>1365-3083</eissn><abstract>'Neonatal' lupus erythematosus (NLE) describes a clinical spectrum of cardiac and non-cardiac abnormalities observed in neonates and foetuses whose mothers have the auto-antibodies anti-SSA/Ro (anti-Ro) and anti-SSB/La (anti-La). Of the cardiac abnormalities, congenital AVB is the most common cardiovascular abnormality found in affected foetuses and infants. Many other cardiovascular manifestations of NLE have been more recently recognized including atrial and ventricular arrhythmias and other conduction abnormalities, myocarditis, cardiomyopathy often with endocardiofibroelastosis and structural heart disease, particularly valvar lesions. In this report, the spectrum of cardiovascular manifestations observed in foetuses and infants with NLE are reviewed and the pathogenesis, diagnosis and clinical outcomes are briefly discussed.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>20696015</pmid><doi>10.1111/j.1365-3083.2010.02437.x</doi><tpages>9</tpages></addata></record> |
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| subjects | Arrhythmias, Cardiac - congenital Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - pathology Arrhythmias, Cardiac - physiopathology Atrioventricular Block - congenital Atrioventricular Block - etiology Atrioventricular Block - immunology Atrioventricular Block - pathology Atrioventricular Block - physiopathology Cardiomyopathies - congenital Cardiomyopathies - etiology Cardiomyopathies - immunology Cardiomyopathies - pathology Cardiomyopathies - physiopathology Heart Diseases - congenital Heart Diseases - etiology Heart Diseases - immunology Heart Diseases - pathology Heart Diseases - physiopathology Humans Infant, Newborn Infant, Newborn, Diseases - etiology Infant, Newborn, Diseases - immunology Infant, Newborn, Diseases - pathology Infant, Newborn, Diseases - physiopathology Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - congenital Lupus Erythematosus, Systemic - immunology |
| title | Spectrum of Cardiac Involvement in Neonatal Lupus |
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