ECVAM international validation study on in vitro tests for acute skin irritation: report on the validity of the EPISKIN and EpiDerm assays and on the Skin Integrity Function Test

ECVAM sponsored a formal validation study on three in vitro tests for skin irritation, of which two employ reconstituted human epidermis models (EPISKIN, EpiDerm), and one, the skin integrity function test (SIFT), employs ex vivo mouse skin. The goal of the study was to assess whether the in vitro t...

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Veröffentlicht in:	Alternatives to laboratory animals 2007-12, Vol.35 (6), p.559-601
Hauptverfasser:	Spielmann, Horst, Hoffmann, Sebastian, Liebsch, Manfred, Botham, Phil, Fentem, Julia H, Eskes, Chantra, Roguet, Roland, Cotovio, José, Cole, Thomas, Worth, Andrew, Heylings, Jon, Jones, Penny, Robles, Catherine, Kandárova, Helena, Gamer, Armin, Remmele, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animal Testing Alternatives Animals cell viability Europe European Union guidelines Humans in vitro studies interleukin-1alpha Irritants - toxicity laboratory animals lead Mice physicochemical properties prediction rabbits Reproducibility of Results Skin - drug effects Skin Diseases - chemically induced Skin Diseases - prevention & control skin irritation Skin Physiological Phenomena skin tests toxicity testing
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