Pituitary adenylyl cyclase-activating polypeptide controls the proliferation of retinal progenitor cells through downregulation of cyclin D1

During retinal development, cell proliferation and exit from the cell cycle must be precisely regulated to ensure the generation of the appropriate numbers and proportions of the various retinal cell types. Previously, we showed that pituitary adenylyl cyclase‐activating polypeptide (PACAP) exerts a...

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Veröffentlicht in:	The European journal of neuroscience 2010-08, Vol.32 (3), p.311-321
Hauptverfasser:	Njaine, Brian, Martins, Rodrigo A. P., Santiago, Marcelo F., Linden, Rafael, Silveira, Mariana S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Blotting, Western cell cycle Cell Proliferation Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Cyclin D1 - genetics Cyclin D1 - metabolism development Down-Regulation Immunohistochemistry Microscopy, Confocal Neurogenesis - physiology PACAP Phosphorylation Pituitary Adenylate Cyclase-Activating Polypeptide - genetics Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism rat Rats Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism Receptors, Vasoactive Intestinal Peptide - genetics Receptors, Vasoactive Intestinal Peptide - metabolism retina Retina - metabolism Retinal Neurons - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Stem Cells Tissue Culture Techniques Vasoactive Intestinal Peptide - metabolism
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