High-Fat Diet Increases Thyrotropin and Oxygen Consumption without Altering Circulating 3,5,3′-Triiodothyronine (T3) and Thyroxine in Rats: The Role of Iodothyronine Deiodinases, Reverse T3 Production, and Whole-Body Fat Oxidation

This study investigated the effects of obesity induced by high-fat (HF) diet on thyroid function and whole-body energy balance. To accomplish that, we assessed the effects of 8 wk of HF diet on several parameters of hypothalamus-pituitary-thyroid axis function. Serum total T4 and T3, rT3, and TSH, t...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2010-07, Vol.151 (7), p.3460-3469
Hauptverfasser:	Araujo, R. L, Andrade, B. M, Padrón, A. S, Gaidhu, M. P, Perry, R. L. S, Carvalho, D. P, Ceddia, R. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism AMP-Activated Protein Kinases - metabolism Animals Blotting, Western Body Composition - drug effects Body Composition - genetics Body fat Diet Dietary Fats - pharmacology Energy balance Energy expenditure Energy Metabolism - drug effects Fat metabolism Glucose Tolerance Test High fat diet Hypothalamus In vivo methods and tests Iodide peroxidase Iodide Peroxidase - metabolism Iodides Leptin Male Metabolism Obesity Oxidation Oxygen consumption Oxygen Consumption - drug effects Partitioning Physical activity Pituitary Polymerase Chain Reaction Rats Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins - metabolism Thyroid Thyroid gland Thyroid Gland - drug effects Thyroid Gland - metabolism Thyroid hormones Thyroid-stimulating hormone Thyrotropin - blood Thyrotropin-releasing hormone Thyroxine Thyroxine - blood Triiodothyronine Triiodothyronine - blood
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