Farnesoid X Receptor Activation Prevents the Development of Vascular Calcification in ApoE−/− Mice With Chronic Kidney Disease

RATIONALE:Vascular calcification is highly associated with cardiovascular morbidity and mortality, especially in patients with chronic kidney disease. The nuclear receptor farnesoid X receptor (FXR) has been implicated in the control of lipid, carbohydrate and bile acid metabolism in several cell ty...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation research 2010-06, Vol.106 (12), p.1807-1817
Hauptverfasser:	Miyazaki-Anzai, Shinobu, Levi, Moshe, Kratzer, Adelheid, Ting, Tabitha C, Lewis, Linda B, Miyazaki, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - cytology Aorta - drug effects Aorta - metabolism Apolipoproteins E - genetics Apolipoproteins E - physiology Biological and medical sciences Calcinosis - physiopathology Calcinosis - prevention & control Cattle Cell Differentiation - drug effects Cells, Cultured Chenodeoxycholic Acid - analogs & derivatives Chenodeoxycholic Acid - pharmacology Chenodeoxycholic Acid - therapeutic use Chronic Disease Disease Models, Animal Fundamental and applied biological sciences. Psychology Kidney Diseases - physiopathology Kidneys Male Medical sciences Mice Mice, Knockout Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Osteogenesis - drug effects Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - drug effects Receptors, Cytoplasmic and Nuclear - physiology Renal failure Signal Transduction - physiology Triglycerides - metabolism Urinary system involvement in other diseases. Miscellaneous Vascular Diseases - physiopathology Vertebrates: cardiovascular system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!