Reduced elimination of IgG antibodies by engineering the variable region

Fc engineering to increase the binding affinity of IgG antibodies to FcRn has been reported to reduce the elimination of IgG antibodies. Herein, we present a novel non-FcRn-dependent approach to reduce the elimination of IgG antibodies. Pharmacokinetic studies conducted in normal mice of various hum...

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Veröffentlicht in:	Protein engineering, design and selection design and selection, 2010-05, Vol.23 (5), p.385-392
Hauptverfasser:	Igawa, T., Tsunoda, H., Tachibana, T., Maeda, A., Mimoto, F., Moriyama, C., Nanami, M., Sekimori, Y., Nabuchi, Y., Aso, Y., Hattori, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-IL6 receptor antibody Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacokinetics antibody engineering CHO Cells Cricetinae Cricetulus Cynomolgus FcRn Genetic Engineering - methods Half-Life Histocompatibility Antigens Class I - metabolism Humans Immunoglobulin G - genetics Immunoglobulin G - metabolism Immunoglobulin Variable Region - genetics Isoelectric Point Mice pharmacokinetics Protein Engineering - methods Receptors, Fc - metabolism
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