Reversal of New-Onset Diabetes through Modulating Inflammation and Stimulating β-Cell Replication in Nonobese Diabetic Mice by a Dipeptidyl Peptidase IV Inhibitor

Inhibition of dipeptidyl peptidase IV (DPP-IV) activity by NVP-DPP728, a DPP-IV inhibitor, improves the therapeutic efficacy of glucagon-like peptide-1 (GLP-1). CD26 is a membrane-associated glycoprotein with DPP-IV activity and is expressed on lymphocytes. We investigated the effect of NVP-DPP728 o...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2010-07, Vol.151 (7), p.3049-3060
Hauptverfasser:	Tian, Lei, Gao, Jie, Hao, Jianqiang, Zhang, Yu, Yi, Huimin, O'Brien, Timothy D, Sorenson, Robert, Luo, Jian, Guo, Zhiguang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beta cells Biological and medical sciences Blood Glucose - drug effects Blood levels Bromodeoxyuridine CD25 antigen CD4 antigen CD4 Antigens - immunology Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - immunology Diabetes. Impaired glucose tolerance Dipeptidyl-peptidase IV Dipeptidyl-Peptidase IV Inhibitors - therapeutic use Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Forkhead Transcription Factors - immunology Foxp3 protein Fundamental and applied biological sciences. Psychology Glucagon Glucagon-like peptide 1 Glucagon-Like Peptide 1 - blood Glycoproteins Immunoregulation Inflammation Inflammatory response Inhibitors Insulin Insulin-Secreting Cells - cytology Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - immunology Insulitis Interleukin-2 Receptor alpha Subunit - immunology Lymph nodes Lymphocytes Lymphocytes T Medical sciences Mice Mice, Inbred NOD Nitriles - therapeutic use Pancreas Peptidases Pyrrolidines - therapeutic use Remission Replication T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Transforming Growth Factor beta1 - blood Transforming growth factor-b1 Vertebrates: endocrinology
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