Organ Trafficking for Live Donor Kidney Transplantation in Indoasians Resident in the West Midlands: High Activity and Poor Outcomes
Some Indoasian (IA) patients with established renal failure travel abroad for commercial kidney transplantation. We compared the 1-year outcomes of IA patients from one UK region who received overseas transplants with IA patients receiving local living donor (LD) kidney transplantation, deceased don...
Gespeichert in:
| Veröffentlicht in: | Transplantation 2010-06, Vol.89 (12), p.1456-1461 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1461 |
|---|---|
| container_issue | 12 |
| container_start_page | 1456 |
| container_title | Transplantation |
| container_volume | 89 |
| creator | KRISHNAN, Nithya COCKWELL, Paul BAHARANI, Jyoti DASGUPTA, Indranil DEVULAPALLY, Pavan GERBER, Barbara HANVESAKUL, Raj HIGGINS, Robert READY, Andrew CARMICHAEL, Paul TOMLINSON, Kerry KUMAR, Shiv |
| description | Some Indoasian (IA) patients with established renal failure travel abroad for commercial kidney transplantation. We compared the 1-year outcomes of IA patients from one UK region who received overseas transplants with IA patients receiving local living donor (LD) kidney transplantation, deceased donor (DD) transplantation, and dialysis.
Between 1996 and 2006, 40 adults were transplanted overseas; 38 were IA, and follow-up data were available on 36 patients. Forty IA patients received LD transplants, and 156 patients received DD transplants locally. A cohort of 120 prospective dialysis patients was also used as a comparator group.
In the overseas cohort, 20 patients (56%) were not active in the UK transplant waiting list at the time of kidney transplantation overseas. One-year graft survival was 87%, and 1-year patient survival was 83%. Composite graft and patient survival was 69.5% at 1 year. In the local LD transplant recipients, patient survival was 97.5% (39 of 40; P=0.03), and graft survival was 97.5% (39 of 40; P=0.06). Composite graft and patient survival was 95% (P=0.003). In the overseas group, 42% had major infections compared with 15% in the local group (P=0.02). One-year graft survival for DD transplant was 84.6% (132 of 156), and 1-year patient survival was 93% (145 of 156; P=NS and P=0.06, respectively). In the dialysis group, 1-year patient survival was 96.7% (116 of 120; P=0.001).
IA patients who choose to travel overseas for kidney transplantation have poor clinical outcomes and should be counseled accordingly. |
| doi_str_mv | 10.1097/TP.0b013e3181da6019 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_754532582</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733303804</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-86b67f3836239c0020417b7ca8b1695f1f15abbe9bf8b9ed3bd101189ce341193</originalsourceid><addsrcrecordid>eNqFkUuLU0EQhRtRnDj6CwTpjbi6Y9Wt--h2N4yPGYwkSMTlpZ-Z1qRvvN0ZyN4fboeJCm5cVXH46lBVh7HnCBcIsn-9Wl6ABiRHKNCqDlA-YDNsqak6EPCQzQAarJCoP2NPUvoGAC31_WN2VgO1TSNgxn4uprWKfDUp74P5HuKa-3Hi83Dn-NsxlvZjsNEdjkRMu42KWeUwRh4iv4l2VCkUnX92KVgX81HOt45_dSnzT8EW3qY3_Dqsb_mlyeEu5AMvGl-OxXqxz2bcuvSUPfJqk9yzUz1nX96_W11dV_PFh5ury3llGsRciU53vSdBXU3SANTlvF73RgmNnWw9emyV1k5qL7R0lrRFQBTSOCoGks7Zq3vf3TT-2JcVh21Ixm3Klm7cp6Fvm5bqVtT_J4kISEBTSLonzTSmNDk_7KawVdNhQBiOOQ2r5fBvTmXqxcl_r7fO_pn5HUwBXp4AlYza-PJ9E9JfrpayxUL_AiQLnDc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733303804</pqid></control><display><type>article</type><title>Organ Trafficking for Live Donor Kidney Transplantation in Indoasians Resident in the West Midlands: High Activity and Poor Outcomes</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>KRISHNAN, Nithya ; COCKWELL, Paul ; BAHARANI, Jyoti ; DASGUPTA, Indranil ; DEVULAPALLY, Pavan ; GERBER, Barbara ; HANVESAKUL, Raj ; HIGGINS, Robert ; READY, Andrew ; CARMICHAEL, Paul ; TOMLINSON, Kerry ; KUMAR, Shiv</creator><creatorcontrib>KRISHNAN, Nithya ; COCKWELL, Paul ; BAHARANI, Jyoti ; DASGUPTA, Indranil ; DEVULAPALLY, Pavan ; GERBER, Barbara ; HANVESAKUL, Raj ; HIGGINS, Robert ; READY, Andrew ; CARMICHAEL, Paul ; TOMLINSON, Kerry ; KUMAR, Shiv</creatorcontrib><description>Some Indoasian (IA) patients with established renal failure travel abroad for commercial kidney transplantation. We compared the 1-year outcomes of IA patients from one UK region who received overseas transplants with IA patients receiving local living donor (LD) kidney transplantation, deceased donor (DD) transplantation, and dialysis.
Between 1996 and 2006, 40 adults were transplanted overseas; 38 were IA, and follow-up data were available on 36 patients. Forty IA patients received LD transplants, and 156 patients received DD transplants locally. A cohort of 120 prospective dialysis patients was also used as a comparator group.
In the overseas cohort, 20 patients (56%) were not active in the UK transplant waiting list at the time of kidney transplantation overseas. One-year graft survival was 87%, and 1-year patient survival was 83%. Composite graft and patient survival was 69.5% at 1 year. In the local LD transplant recipients, patient survival was 97.5% (39 of 40; P=0.03), and graft survival was 97.5% (39 of 40; P=0.06). Composite graft and patient survival was 95% (P=0.003). In the overseas group, 42% had major infections compared with 15% in the local group (P=0.02). One-year graft survival for DD transplant was 84.6% (132 of 156), and 1-year patient survival was 93% (145 of 156; P=NS and P=0.06, respectively). In the dialysis group, 1-year patient survival was 96.7% (116 of 120; P=0.001).
IA patients who choose to travel overseas for kidney transplantation have poor clinical outcomes and should be counseled accordingly.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/TP.0b013e3181da6019</identifier><identifier>PMID: 20354480</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Asia ; Biological and medical sciences ; China ; Clinical death. Palliative care. Organ gift and preservation ; Cohort Studies ; Crime ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft Survival ; Humans ; India ; Kidney Transplantation - methods ; Living Donors ; Male ; Medical sciences ; Middle Aged ; Renal Insufficiency - therapy ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Tissue and Organ Procurement - legislation & jurisprudence ; Tissue and Organ Procurement - methods ; Tissue, organ and graft immunology ; Travel ; Treatment Outcome ; United Kingdom</subject><ispartof>Transplantation, 2010-06, Vol.89 (12), p.1456-1461</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-86b67f3836239c0020417b7ca8b1695f1f15abbe9bf8b9ed3bd101189ce341193</citedby><cites>FETCH-LOGICAL-c411t-86b67f3836239c0020417b7ca8b1695f1f15abbe9bf8b9ed3bd101189ce341193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22995120$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20354480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KRISHNAN, Nithya</creatorcontrib><creatorcontrib>COCKWELL, Paul</creatorcontrib><creatorcontrib>BAHARANI, Jyoti</creatorcontrib><creatorcontrib>DASGUPTA, Indranil</creatorcontrib><creatorcontrib>DEVULAPALLY, Pavan</creatorcontrib><creatorcontrib>GERBER, Barbara</creatorcontrib><creatorcontrib>HANVESAKUL, Raj</creatorcontrib><creatorcontrib>HIGGINS, Robert</creatorcontrib><creatorcontrib>READY, Andrew</creatorcontrib><creatorcontrib>CARMICHAEL, Paul</creatorcontrib><creatorcontrib>TOMLINSON, Kerry</creatorcontrib><creatorcontrib>KUMAR, Shiv</creatorcontrib><title>Organ Trafficking for Live Donor Kidney Transplantation in Indoasians Resident in the West Midlands: High Activity and Poor Outcomes</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Some Indoasian (IA) patients with established renal failure travel abroad for commercial kidney transplantation. We compared the 1-year outcomes of IA patients from one UK region who received overseas transplants with IA patients receiving local living donor (LD) kidney transplantation, deceased donor (DD) transplantation, and dialysis.
Between 1996 and 2006, 40 adults were transplanted overseas; 38 were IA, and follow-up data were available on 36 patients. Forty IA patients received LD transplants, and 156 patients received DD transplants locally. A cohort of 120 prospective dialysis patients was also used as a comparator group.
In the overseas cohort, 20 patients (56%) were not active in the UK transplant waiting list at the time of kidney transplantation overseas. One-year graft survival was 87%, and 1-year patient survival was 83%. Composite graft and patient survival was 69.5% at 1 year. In the local LD transplant recipients, patient survival was 97.5% (39 of 40; P=0.03), and graft survival was 97.5% (39 of 40; P=0.06). Composite graft and patient survival was 95% (P=0.003). In the overseas group, 42% had major infections compared with 15% in the local group (P=0.02). One-year graft survival for DD transplant was 84.6% (132 of 156), and 1-year patient survival was 93% (145 of 156; P=NS and P=0.06, respectively). In the dialysis group, 1-year patient survival was 96.7% (116 of 120; P=0.001).
IA patients who choose to travel overseas for kidney transplantation have poor clinical outcomes and should be counseled accordingly.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Asia</subject><subject>Biological and medical sciences</subject><subject>China</subject><subject>Clinical death. Palliative care. Organ gift and preservation</subject><subject>Cohort Studies</subject><subject>Crime</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>India</subject><subject>Kidney Transplantation - methods</subject><subject>Living Donors</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Renal Insufficiency - therapy</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>Tissue and Organ Procurement - legislation & jurisprudence</subject><subject>Tissue and Organ Procurement - methods</subject><subject>Tissue, organ and graft immunology</subject><subject>Travel</subject><subject>Treatment Outcome</subject><subject>United Kingdom</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLU0EQhRtRnDj6CwTpjbi6Y9Wt--h2N4yPGYwkSMTlpZ-Z1qRvvN0ZyN4fboeJCm5cVXH46lBVh7HnCBcIsn-9Wl6ABiRHKNCqDlA-YDNsqak6EPCQzQAarJCoP2NPUvoGAC31_WN2VgO1TSNgxn4uprWKfDUp74P5HuKa-3Hi83Dn-NsxlvZjsNEdjkRMu42KWeUwRh4iv4l2VCkUnX92KVgX81HOt45_dSnzT8EW3qY3_Dqsb_mlyeEu5AMvGl-OxXqxz2bcuvSUPfJqk9yzUz1nX96_W11dV_PFh5ury3llGsRciU53vSdBXU3SANTlvF73RgmNnWw9emyV1k5qL7R0lrRFQBTSOCoGks7Zq3vf3TT-2JcVh21Ixm3Klm7cp6Fvm5bqVtT_J4kISEBTSLonzTSmNDk_7KawVdNhQBiOOQ2r5fBvTmXqxcl_r7fO_pn5HUwBXp4AlYza-PJ9E9JfrpayxUL_AiQLnDc</recordid><startdate>20100627</startdate><enddate>20100627</enddate><creator>KRISHNAN, Nithya</creator><creator>COCKWELL, Paul</creator><creator>BAHARANI, Jyoti</creator><creator>DASGUPTA, Indranil</creator><creator>DEVULAPALLY, Pavan</creator><creator>GERBER, Barbara</creator><creator>HANVESAKUL, Raj</creator><creator>HIGGINS, Robert</creator><creator>READY, Andrew</creator><creator>CARMICHAEL, Paul</creator><creator>TOMLINSON, Kerry</creator><creator>KUMAR, Shiv</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20100627</creationdate><title>Organ Trafficking for Live Donor Kidney Transplantation in Indoasians Resident in the West Midlands: High Activity and Poor Outcomes</title><author>KRISHNAN, Nithya ; COCKWELL, Paul ; BAHARANI, Jyoti ; DASGUPTA, Indranil ; DEVULAPALLY, Pavan ; GERBER, Barbara ; HANVESAKUL, Raj ; HIGGINS, Robert ; READY, Andrew ; CARMICHAEL, Paul ; TOMLINSON, Kerry ; KUMAR, Shiv</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-86b67f3836239c0020417b7ca8b1695f1f15abbe9bf8b9ed3bd101189ce341193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Asia</topic><topic>Biological and medical sciences</topic><topic>China</topic><topic>Clinical death. Palliative care. Organ gift and preservation</topic><topic>Cohort Studies</topic><topic>Crime</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>India</topic><topic>Kidney Transplantation - methods</topic><topic>Living Donors</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Renal Insufficiency - therapy</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>Tissue and Organ Procurement - legislation & jurisprudence</topic><topic>Tissue and Organ Procurement - methods</topic><topic>Tissue, organ and graft immunology</topic><topic>Travel</topic><topic>Treatment Outcome</topic><topic>United Kingdom</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KRISHNAN, Nithya</creatorcontrib><creatorcontrib>COCKWELL, Paul</creatorcontrib><creatorcontrib>BAHARANI, Jyoti</creatorcontrib><creatorcontrib>DASGUPTA, Indranil</creatorcontrib><creatorcontrib>DEVULAPALLY, Pavan</creatorcontrib><creatorcontrib>GERBER, Barbara</creatorcontrib><creatorcontrib>HANVESAKUL, Raj</creatorcontrib><creatorcontrib>HIGGINS, Robert</creatorcontrib><creatorcontrib>READY, Andrew</creatorcontrib><creatorcontrib>CARMICHAEL, Paul</creatorcontrib><creatorcontrib>TOMLINSON, Kerry</creatorcontrib><creatorcontrib>KUMAR, Shiv</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KRISHNAN, Nithya</au><au>COCKWELL, Paul</au><au>BAHARANI, Jyoti</au><au>DASGUPTA, Indranil</au><au>DEVULAPALLY, Pavan</au><au>GERBER, Barbara</au><au>HANVESAKUL, Raj</au><au>HIGGINS, Robert</au><au>READY, Andrew</au><au>CARMICHAEL, Paul</au><au>TOMLINSON, Kerry</au><au>KUMAR, Shiv</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Organ Trafficking for Live Donor Kidney Transplantation in Indoasians Resident in the West Midlands: High Activity and Poor Outcomes</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2010-06-27</date><risdate>2010</risdate><volume>89</volume><issue>12</issue><spage>1456</spage><epage>1461</epage><pages>1456-1461</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Some Indoasian (IA) patients with established renal failure travel abroad for commercial kidney transplantation. We compared the 1-year outcomes of IA patients from one UK region who received overseas transplants with IA patients receiving local living donor (LD) kidney transplantation, deceased donor (DD) transplantation, and dialysis.
Between 1996 and 2006, 40 adults were transplanted overseas; 38 were IA, and follow-up data were available on 36 patients. Forty IA patients received LD transplants, and 156 patients received DD transplants locally. A cohort of 120 prospective dialysis patients was also used as a comparator group.
In the overseas cohort, 20 patients (56%) were not active in the UK transplant waiting list at the time of kidney transplantation overseas. One-year graft survival was 87%, and 1-year patient survival was 83%. Composite graft and patient survival was 69.5% at 1 year. In the local LD transplant recipients, patient survival was 97.5% (39 of 40; P=0.03), and graft survival was 97.5% (39 of 40; P=0.06). Composite graft and patient survival was 95% (P=0.003). In the overseas group, 42% had major infections compared with 15% in the local group (P=0.02). One-year graft survival for DD transplant was 84.6% (132 of 156), and 1-year patient survival was 93% (145 of 156; P=NS and P=0.06, respectively). In the dialysis group, 1-year patient survival was 96.7% (116 of 120; P=0.001).
IA patients who choose to travel overseas for kidney transplantation have poor clinical outcomes and should be counseled accordingly.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>20354480</pmid><doi>10.1097/TP.0b013e3181da6019</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 2010-06, Vol.89 (12), p.1456-1461 |
| issn | 0041-1337 1534-6080 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_754532582 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Asia Biological and medical sciences China Clinical death. Palliative care. Organ gift and preservation Cohort Studies Crime Female Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Survival Humans India Kidney Transplantation - methods Living Donors Male Medical sciences Middle Aged Renal Insufficiency - therapy Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Tissue and Organ Procurement - legislation & jurisprudence Tissue and Organ Procurement - methods Tissue, organ and graft immunology Travel Treatment Outcome United Kingdom |
| title | Organ Trafficking for Live Donor Kidney Transplantation in Indoasians Resident in the West Midlands: High Activity and Poor Outcomes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T01%3A31%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Organ%20Trafficking%20for%20Live%20Donor%20Kidney%20Transplantation%20in%20Indoasians%20Resident%20in%20the%20West%20Midlands:%20High%20Activity%20and%20Poor%20Outcomes&rft.jtitle=Transplantation&rft.au=KRISHNAN,%20Nithya&rft.date=2010-06-27&rft.volume=89&rft.issue=12&rft.spage=1456&rft.epage=1461&rft.pages=1456-1461&rft.issn=0041-1337&rft.eissn=1534-6080&rft.coden=TRPLAU&rft_id=info:doi/10.1097/TP.0b013e3181da6019&rft_dat=%3Cproquest_cross%3E733303804%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733303804&rft_id=info:pmid/20354480&rfr_iscdi=true |