Characterization of Rabbit Antithymocyte Globulins-Induced CD25+ Regulatory T Cells From Cells of Patients With End-Stage Renal Disease

BACKGROUND.: Rabbit antithymocyte globulins (rATGs) are known to convert CD4CD25FoxP3 T cells from healthy individuals to CD4CD25FoxP3 T cells. In this study, we investigated the effect of rATG on the induction of regulatory T cells (Tregs) from blood cells of patients with end-stage renal disease w...

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Veröffentlicht in:	Transplantation 2010-03, Vol.89 (6), p.655-666
Hauptverfasser:	SEWGOBIND, Varsha D. K. D, VAN DER LAAN, Luc J. W, KHO, Marcia M. L, KRAAIJEVELD, Rens, KOREVAAR, Sander S, VAN DAM, Thea, IJZERMANS, Jan N. M, WEIMAR, Willem, BAAN, Carla C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antilymphocyte Serum - immunology Biological and medical sciences Case-Control Studies Cells, Cultured Cytokines - genetics Cytotoxicity, Immunologic Dose-Response Relationship, Immunologic Flow Cytometry Forkhead Transcription Factors - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Granzymes - genetics Humans Immunophenotyping - methods Interleukin-2 Receptor alpha Subunit - metabolism Interleukin-7 Receptor alpha Subunit - metabolism Kidney Failure, Chronic - immunology Kidney Failure, Chronic - surgery Kidney Transplantation Leukocytes, Mononuclear - immunology Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Perforin - genetics Phenotype Protein Binding Rabbits Renal failure RNA, Messenger - metabolism Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Regulatory - immunology Time Factors Tissue, organ and graft immunology
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