Pattern of Cerebrospinal Fluid Lactic Dehydrogenase During Treatment of Bacterial Meningitis
Bacterial and aseptic meningitis are characterized by distinctive lactic dehydrogenase isoenzyme patterns. No studies have quantified the dynamics of lactic dehydrogenase isoenzyme distribution during treated bacterial meningitis. We used a retrospective case-series design, and reviewed files of all...
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| Veröffentlicht in: | Pediatric neurology 2010-06, Vol.42 (6), p.413-416 |
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| creator | Nussinovitch, Udi, MD Finkelstein, Yaron, MD Harel, Daniella, PhD Nussinovitch, Naomi, MD Nussinovitch, Moshe, MD |
| description | Bacterial and aseptic meningitis are characterized by distinctive lactic dehydrogenase isoenzyme patterns. No studies have quantified the dynamics of lactic dehydrogenase isoenzyme distribution during treated bacterial meningitis. We used a retrospective case-series design, and reviewed files of all neonates with bacterial meningitis who attended our pediatric tertiary medical center for 8 years period. We identified neonates in whom a repeated lumbar puncture was indicated. Findings of cerebrospinal fluid analysis, including levels of lactic dehydrogenase isoenzymes, were compared with an age-matched reference group. In two patients with meningitis, lumbar puncture with cerebrospinal fluid analysis was repeated because of inadequate response to treatment or initially obscure etiologic pathogens. Both patients had initially low levels of lactic dehydrogenase-1 and lactic dehydrogenase-2 and high levels of lactic dehydrogenase-4 and lactic dehydrogenase-5, similar to other patients with bacterial meningitis. The distribution pattern of lactic dehydrogenase isoenzyme normalized after adequate antibiotic treatment. In light of the encouraging results in these two patients, further studies are warranted regarding the value of lactic dehydrogenase isoenzyme measurements for follow-up purposes and for evaluations of response to treatment. |
| doi_str_mv | 10.1016/j.pediatrneurol.2010.01.013 |
| format | Article |
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No studies have quantified the dynamics of lactic dehydrogenase isoenzyme distribution during treated bacterial meningitis. We used a retrospective case-series design, and reviewed files of all neonates with bacterial meningitis who attended our pediatric tertiary medical center for 8 years period. We identified neonates in whom a repeated lumbar puncture was indicated. Findings of cerebrospinal fluid analysis, including levels of lactic dehydrogenase isoenzymes, were compared with an age-matched reference group. In two patients with meningitis, lumbar puncture with cerebrospinal fluid analysis was repeated because of inadequate response to treatment or initially obscure etiologic pathogens. Both patients had initially low levels of lactic dehydrogenase-1 and lactic dehydrogenase-2 and high levels of lactic dehydrogenase-4 and lactic dehydrogenase-5, similar to other patients with bacterial meningitis. The distribution pattern of lactic dehydrogenase isoenzyme normalized after adequate antibiotic treatment. In light of the encouraging results in these two patients, further studies are warranted regarding the value of lactic dehydrogenase isoenzyme measurements for follow-up purposes and for evaluations of response to treatment.</description><identifier>ISSN: 0887-8994</identifier><identifier>EISSN: 1873-5150</identifier><identifier>DOI: 10.1016/j.pediatrneurol.2010.01.013</identifier><identifier>PMID: 20472193</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Bacteria ; Biological and medical sciences ; Human viral diseases ; Humans ; Infant ; Infant, Newborn ; Infectious diseases ; Isoenzymes - cerebrospinal fluid ; L-Lactate Dehydrogenase - cerebrospinal fluid ; Medical sciences ; Meningitis, Bacterial - cerebrospinal fluid ; Meningitis, Bacterial - drug therapy ; Meningitis, Bacterial - enzymology ; Neurology ; Pasteurella Infections - cerebrospinal fluid ; Pasteurella Infections - drug therapy ; Pasteurella Infections - enzymology ; Pediatrics ; Retrospective Studies ; Streptococcal Infections - cerebrospinal fluid ; Streptococcal Infections - drug therapy ; Streptococcal Infections - enzymology ; Time Factors ; Treatment Outcome ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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No studies have quantified the dynamics of lactic dehydrogenase isoenzyme distribution during treated bacterial meningitis. We used a retrospective case-series design, and reviewed files of all neonates with bacterial meningitis who attended our pediatric tertiary medical center for 8 years period. We identified neonates in whom a repeated lumbar puncture was indicated. Findings of cerebrospinal fluid analysis, including levels of lactic dehydrogenase isoenzymes, were compared with an age-matched reference group. In two patients with meningitis, lumbar puncture with cerebrospinal fluid analysis was repeated because of inadequate response to treatment or initially obscure etiologic pathogens. Both patients had initially low levels of lactic dehydrogenase-1 and lactic dehydrogenase-2 and high levels of lactic dehydrogenase-4 and lactic dehydrogenase-5, similar to other patients with bacterial meningitis. The distribution pattern of lactic dehydrogenase isoenzyme normalized after adequate antibiotic treatment. In light of the encouraging results in these two patients, further studies are warranted regarding the value of lactic dehydrogenase isoenzyme measurements for follow-up purposes and for evaluations of response to treatment.</description><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Isoenzymes - cerebrospinal fluid</subject><subject>L-Lactate Dehydrogenase - cerebrospinal fluid</subject><subject>Medical sciences</subject><subject>Meningitis, Bacterial - cerebrospinal fluid</subject><subject>Meningitis, Bacterial - drug therapy</subject><subject>Meningitis, Bacterial - enzymology</subject><subject>Neurology</subject><subject>Pasteurella Infections - cerebrospinal fluid</subject><subject>Pasteurella Infections - drug therapy</subject><subject>Pasteurella Infections - enzymology</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><subject>Streptococcal Infections - cerebrospinal fluid</subject><subject>Streptococcal Infections - drug therapy</subject><subject>Streptococcal Infections - enzymology</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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| subjects | Anti-Bacterial Agents - therapeutic use Antibiotics Bacteria Biological and medical sciences Human viral diseases Humans Infant Infant, Newborn Infectious diseases Isoenzymes - cerebrospinal fluid L-Lactate Dehydrogenase - cerebrospinal fluid Medical sciences Meningitis, Bacterial - cerebrospinal fluid Meningitis, Bacterial - drug therapy Meningitis, Bacterial - enzymology Neurology Pasteurella Infections - cerebrospinal fluid Pasteurella Infections - drug therapy Pasteurella Infections - enzymology Pediatrics Retrospective Studies Streptococcal Infections - cerebrospinal fluid Streptococcal Infections - drug therapy Streptococcal Infections - enzymology Time Factors Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Pattern of Cerebrospinal Fluid Lactic Dehydrogenase During Treatment of Bacterial Meningitis |
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