A call to arms: Using RNAi screening to improve oncolytic viral therapy
Abstract Replicating virus-based therapeutics for cancer, or oncolytic virus therapy (OVT), is rapidly emerging as a promising treatment modality for a wide range of cancers. In pre-clinical studies, oncolytic viruses have produced remarkable results in a variety of experimental animal models, and s...
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| Veröffentlicht in: | Cytokine & growth factor reviews 2010-04, Vol.21 (2), p.161-167 |
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| creator | Mahoney, D.J Stojdl, D.F |
| description | Abstract Replicating virus-based therapeutics for cancer, or oncolytic virus therapy (OVT), is rapidly emerging as a promising treatment modality for a wide range of cancers. In pre-clinical studies, oncolytic viruses have produced remarkable results in a variety of experimental animal models, and several viruses have entered phase I/II clinical trials. However, OVT is not effective against all tumours, with major treatment bottlenecks being the inability to infect, replicate within, or kill certain cancer cells. Unfortunately, the underlying molecular mechanisms governing these limitations are largely unknown. Recently, RNAi technology has been adapted for systematic interrogation of entire eukaryotic genomes. Since then, several groups have conducted genome-wide RNAi screens to study host/virus interactions. Herein we briefly summarize RNAi screening and its recent application to virology, and propose its use in overcoming key barriers to successful OVT. |
| doi_str_mv | 10.1016/j.cytogfr.2010.02.013 |
| format | Article |
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| identifier | ISSN: 1359-6101 |
| ispartof | Cytokine & growth factor reviews, 2010-04, Vol.21 (2), p.161-167 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Advanced Basic Science Animal models Animals Functional genomic screening Host-Pathogen Interactions Host/virus interaction Humans Oncolytic therapy Oncolytic Virotherapy - methods Oncolytic Viruses RNA Interference RNAi Virus Replication |
| title | A call to arms: Using RNAi screening to improve oncolytic viral therapy |
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