Isolation of selective 3H-chlornaltrexamine-bound complexes, possible opioid receptor components in brains of mice

The nonequilibrium narcotic antagonist, chlornaltrexamine (CNA) was used to bind selectively and covalently pioid specific sites on brain membrane preparations. Selective binding of [ 3H]CNA occured with a saturation maximum of 185 fmol/mg protein. Bound [ 3H]CNA was extracted with Triton X-100, dia...

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Veröffentlicht in:	Life sciences (1973) 1980-12, Vol.27 (22), p.2063-2069
Hauptverfasser:	Caruso, Thomas P., Larson, Dennis L., Portoghese, Philip S., Takemori, A.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Chromatography, Gel Dextrorphan - pharmacology In Vitro Techniques Mice Naloxone - analogs & derivatives Naltrexone - analogs & derivatives Naltrexone - metabolism Naltrexone - pharmacology Nitrogen Mustard Compounds - metabolism Receptors, Opioid - isolation & purification Receptors, Opioid - metabolism
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