Superoxide Production by Purified Hamster Hepatic Nuclei

We have found that hamster hepatic nuclei produce substantial quantities of superoxide in the presence of NADPH. We have determined that these nuclei contain copper-zinc superoxide dismutase which can be almost entirely removed by extensive washing. We have suggested that this nuclear superoxide dis...

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Veröffentlicht in:	Molecular pharmacology 1980-11, Vol.18 (3), p.588-593
Hauptverfasser:	Patton, S E, Rosen, G M, Rauckman, E J
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Sprache:	eng
Schlagworte:	Animals Cell Nucleus - metabolism Cricetinae Cytochrome P-450 Enzyme System - metabolism In Vitro Techniques Liver - metabolism Liver - ultrastructure Male Mesocricetus Mixed Function Oxygenases - metabolism Oxygen - metabolism Superoxide Dismutase - metabolism Superoxides - metabolism
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creator	Patton, S E Rosen, G M Rauckman, E J
description	We have found that hamster hepatic nuclei produce substantial quantities of superoxide in the presence of NADPH. We have determined that these nuclei contain copper-zinc superoxide dismutase which can be almost entirely removed by extensive washing. We have suggested that this nuclear superoxide dismutase is in equilibrium with cytoplasmic superoxide dismutase. Finally, we have presented evidence which demonstrates that the flavoprotein FAD-monooxygenase is responsible for most of the nuclear superoxide production.
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We have determined that these nuclei contain copper-zinc superoxide dismutase which can be almost entirely removed by extensive washing. We have suggested that this nuclear superoxide dismutase is in equilibrium with cytoplasmic superoxide dismutase. Finally, we have presented evidence which demonstrates that the flavoprotein FAD-monooxygenase is responsible for most of the nuclear superoxide production.</description><identifier>ISSN: 0026-895X</identifier><identifier>EISSN: 1521-0111</identifier><identifier>PMID: 6258050</identifier><language>eng</language><publisher>United States: American Society for Pharmacology and Experimental Therapeutics</publisher><subject>Animals ; Cell Nucleus - metabolism ; Cricetinae ; Cytochrome P-450 Enzyme System - metabolism ; In Vitro Techniques ; Liver - metabolism ; Liver - ultrastructure ; Male ; Mesocricetus ; Mixed Function Oxygenases - metabolism ; Oxygen - metabolism ; Superoxide Dismutase - metabolism ; Superoxides - metabolism</subject><ispartof>Molecular pharmacology, 1980-11, Vol.18 (3), p.588-593</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6258050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patton, S E</creatorcontrib><creatorcontrib>Rosen, G M</creatorcontrib><creatorcontrib>Rauckman, E J</creatorcontrib><title>Superoxide Production by Purified Hamster Hepatic Nuclei</title><title>Molecular pharmacology</title><addtitle>Mol Pharmacol</addtitle><description>We have found that hamster hepatic nuclei produce substantial quantities of superoxide in the presence of NADPH. We have determined that these nuclei contain copper-zinc superoxide dismutase which can be almost entirely removed by extensive washing. We have suggested that this nuclear superoxide dismutase is in equilibrium with cytoplasmic superoxide dismutase. 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We have determined that these nuclei contain copper-zinc superoxide dismutase which can be almost entirely removed by extensive washing. We have suggested that this nuclear superoxide dismutase is in equilibrium with cytoplasmic superoxide dismutase. Finally, we have presented evidence which demonstrates that the flavoprotein FAD-monooxygenase is responsible for most of the nuclear superoxide production.</abstract><cop>United States</cop><pub>American Society for Pharmacology and Experimental Therapeutics</pub><pmid>6258050</pmid><tpages>6</tpages></addata></record>
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source	MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects	Animals Cell Nucleus - metabolism Cricetinae Cytochrome P-450 Enzyme System - metabolism In Vitro Techniques Liver - metabolism Liver - ultrastructure Male Mesocricetus Mixed Function Oxygenases - metabolism Oxygen - metabolism Superoxide Dismutase - metabolism Superoxides - metabolism
title	Superoxide Production by Purified Hamster Hepatic Nuclei
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