Glucuronide and sulphate conjugation in isolated liver cells from control and phenobarbital- or PCB-treated rats

The conjugation of 4-methylumbelliferone, p-nitrophenol and o-aminophenol in isolated rat liver cells was studied. It was found that for maximum sulphate conjugation to take place a very high sulphate concentration (50 mM) was needed, indicating that the rate limiting step may be the formation of ‘a...

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Veröffentlicht in:	Biochemical pharmacology 1980-11, Vol.29 (21), p.2963-2968
Hauptverfasser:	Suolinna, Else-Maj, Mäntylä, Eero
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminophenols - metabolism Animals Glucuronates - metabolism Hymecromone - metabolism In Vitro Techniques Liver - drug effects Liver - metabolism Male Nitrophenols - metabolism Phenobarbital - pharmacology Polychlorinated Biphenyls - pharmacology Rats Sulfates - metabolism
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