Depression of glucose utilization by intralipid in the post-traumatic period: An experimental study
We investigated the accelerated clearance of Intralipid (IL) in the immediate post-traumatic period and the influence of the concomitant rise in fatty acid (FFA) metabolism on carbohydrate tolerance. As a result we postulate that intermediary products of fatty acid oxidation inhibit key enzymes in t...
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| Veröffentlicht in: | Journal of pediatric surgery 1980-12, Vol.15 (6), p.739-745 |
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| container_end_page | 745 |
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| container_issue | 6 |
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| container_title | Journal of pediatric surgery |
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| creator | Das, John B. Joshi, Indira D. Philippart, Arvin I. |
| description | We investigated the accelerated clearance of Intralipid (IL) in the immediate post-traumatic period and the influence of the concomitant rise in fatty acid (FFA) metabolism on carbohydrate tolerance. As a result we postulate that intermediary products of fatty acid oxidation inhibit key enzymes in the glycolytic pathway. The fatty acidemia and its metabolic sequlae can be avoided by intermittent Intralipid supplementation (at low rates) during TPN. It will assure (1) a larger carbohydrate-to-fat caloric ratio during infusion and (2) cyclical regeneration of the enzyme systems involved in lipid metabolism. |
| doi_str_mv | 10.1016/S0022-3468(80)80275-2 |
| format | Article |
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As a result we postulate that intermediary products of fatty acid oxidation inhibit key enzymes in the glycolytic pathway. The fatty acidemia and its metabolic sequlae can be avoided by intermittent Intralipid supplementation (at low rates) during TPN. It will assure (1) a larger carbohydrate-to-fat caloric ratio during infusion and (2) cyclical regeneration of the enzyme systems involved in lipid metabolism.</description><identifier>ISSN: 0022-3468</identifier><identifier>EISSN: 1531-5037</identifier><identifier>DOI: 10.1016/S0022-3468(80)80275-2</identifier><identifier>PMID: 7007605</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Antigens ; Blood Glucose - metabolism ; Chylomicrons - blood ; Depression, Chemical ; Disease Models, Animal ; Dogs ; Epinephrine - blood ; Fat Emulsions, Intravenous - metabolism ; fatty acid metabolism ; Fatty Acids, Nonesterified - blood ; Female ; Glucagon - blood ; Glucagon - immunology ; Glucose - metabolism ; Insulin - metabolism ; Intralipid ; metabolic response to trauma ; Norepinephrine - blood ; Time Factors ; Wounds and Injuries - metabolism</subject><ispartof>Journal of pediatric surgery, 1980-12, Vol.15 (6), p.739-745</ispartof><rights>1980 Grune & Stratton, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-12ff1401fd2984367ae656dc786586901c85e453c9128ed3511a6840d1d00ca03</citedby><cites>FETCH-LOGICAL-c360t-12ff1401fd2984367ae656dc786586901c85e453c9128ed3511a6840d1d00ca03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022346880802752$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7007605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Das, John B.</creatorcontrib><creatorcontrib>Joshi, Indira D.</creatorcontrib><creatorcontrib>Philippart, Arvin I.</creatorcontrib><title>Depression of glucose utilization by intralipid in the post-traumatic period: An experimental study</title><title>Journal of pediatric surgery</title><addtitle>J Pediatr Surg</addtitle><description>We investigated the accelerated clearance of Intralipid (IL) in the immediate post-traumatic period and the influence of the concomitant rise in fatty acid (FFA) metabolism on carbohydrate tolerance. As a result we postulate that intermediary products of fatty acid oxidation inhibit key enzymes in the glycolytic pathway. The fatty acidemia and its metabolic sequlae can be avoided by intermittent Intralipid supplementation (at low rates) during TPN. It will assure (1) a larger carbohydrate-to-fat caloric ratio during infusion and (2) cyclical regeneration of the enzyme systems involved in lipid metabolism.</description><subject>Animals</subject><subject>Antigens</subject><subject>Blood Glucose - metabolism</subject><subject>Chylomicrons - blood</subject><subject>Depression, Chemical</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Epinephrine - blood</subject><subject>Fat Emulsions, Intravenous - metabolism</subject><subject>fatty acid metabolism</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Female</subject><subject>Glucagon - blood</subject><subject>Glucagon - immunology</subject><subject>Glucose - metabolism</subject><subject>Insulin - metabolism</subject><subject>Intralipid</subject><subject>metabolic response to trauma</subject><subject>Norepinephrine - blood</subject><subject>Time Factors</subject><subject>Wounds and Injuries - metabolism</subject><issn>0022-3468</issn><issn>1531-5037</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFP3DAQhS1UtGyhPwHJJ0QPgbEdO95eEKItRULiAD1bXntCXWXj1HYqll_fhF1x7cn2mzfzxh8hpwwuGDB1-QjAeSVqpc81fNbAG1nxA7JkUrBKgmg-kOW75Yh8zPk3wCQDW5BFA9AokEvivuKQMOcQexpb-tyNLmakYwldeLVlltdbGvqSbBeG4KcrLb-QDjGXahLHzWRydMAUov9Cr3uKL_Njg32xHc1l9NsTctjaLuOn_XlMfn7_9nTzo7p_uL27ub6vnFBQKsbbltXAWs9Xuhaqsaik8q7RSmq1Aua0xFoKt2JcoxeSMat0DZ55AGdBHJOz3dwhxT8j5mI2ITvsOttjHLNpZM1roWej3BldijknbM0wbWzT1jAwM1zzBtfM5IwG8wbX8KnvdB8wrjfo37v2NKf61a6O0y__Bkwmu4C9Qx8SumJ8DP9J-AdPv4l3</recordid><startdate>198012</startdate><enddate>198012</enddate><creator>Das, John B.</creator><creator>Joshi, Indira D.</creator><creator>Philippart, Arvin I.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198012</creationdate><title>Depression of glucose utilization by intralipid in the post-traumatic period: An experimental study</title><author>Das, John B. ; Joshi, Indira D. ; Philippart, Arvin I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-12ff1401fd2984367ae656dc786586901c85e453c9128ed3511a6840d1d00ca03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Blood Glucose - metabolism</topic><topic>Chylomicrons - blood</topic><topic>Depression, Chemical</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Epinephrine - blood</topic><topic>Fat Emulsions, Intravenous - metabolism</topic><topic>fatty acid metabolism</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Female</topic><topic>Glucagon - blood</topic><topic>Glucagon - immunology</topic><topic>Glucose - metabolism</topic><topic>Insulin - metabolism</topic><topic>Intralipid</topic><topic>metabolic response to trauma</topic><topic>Norepinephrine - blood</topic><topic>Time Factors</topic><topic>Wounds and Injuries - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Das, John B.</creatorcontrib><creatorcontrib>Joshi, Indira D.</creatorcontrib><creatorcontrib>Philippart, Arvin I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Das, John B.</au><au>Joshi, Indira D.</au><au>Philippart, Arvin I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depression of glucose utilization by intralipid in the post-traumatic period: An experimental study</atitle><jtitle>Journal of pediatric surgery</jtitle><addtitle>J Pediatr Surg</addtitle><date>1980-12</date><risdate>1980</risdate><volume>15</volume><issue>6</issue><spage>739</spage><epage>745</epage><pages>739-745</pages><issn>0022-3468</issn><eissn>1531-5037</eissn><abstract>We investigated the accelerated clearance of Intralipid (IL) in the immediate post-traumatic period and the influence of the concomitant rise in fatty acid (FFA) metabolism on carbohydrate tolerance. As a result we postulate that intermediary products of fatty acid oxidation inhibit key enzymes in the glycolytic pathway. The fatty acidemia and its metabolic sequlae can be avoided by intermittent Intralipid supplementation (at low rates) during TPN. It will assure (1) a larger carbohydrate-to-fat caloric ratio during infusion and (2) cyclical regeneration of the enzyme systems involved in lipid metabolism.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7007605</pmid><doi>10.1016/S0022-3468(80)80275-2</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of pediatric surgery, 1980-12, Vol.15 (6), p.739-745 |
| issn | 0022-3468 1531-5037 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antigens Blood Glucose - metabolism Chylomicrons - blood Depression, Chemical Disease Models, Animal Dogs Epinephrine - blood Fat Emulsions, Intravenous - metabolism fatty acid metabolism Fatty Acids, Nonesterified - blood Female Glucagon - blood Glucagon - immunology Glucose - metabolism Insulin - metabolism Intralipid metabolic response to trauma Norepinephrine - blood Time Factors Wounds and Injuries - metabolism |
| title | Depression of glucose utilization by intralipid in the post-traumatic period: An experimental study |
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