Isolation and Chemical Composition of Complement-Fixing Antigens From Leptospires
Summary A chemical separation procedure which yields four arbitrary cell fractions has been developed and applied to three serotypes of leptospires. The four complement-fixing fractions are non-dialyzable, pentose-containing materials, the serological activities of which have been measured semi-quan...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1954-01, Vol.85 (1), p.32-37 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 85 |
| creator | Schneider, Morris D. |
| description | Summary
A chemical separation procedure which yields four arbitrary cell fractions has been developed and applied to three serotypes of leptospires. The four complement-fixing fractions are non-dialyzable, pentose-containing materials, the serological activities of which have been measured semi-quantitatively. One or more complement-fixing principles, of nature not yet known, are concentrated in two chemically distinct, relatively free of protein, polysaccharide-containing cell fractions. The protein constituent (Fraction 3) of the leptospiral cell was poorly reactive in the complement fixation test. Spectrophotometric differences among preparations of Fraction 2 from three serotypes may prove to be an aid in the differentiation of serotypes. |
| doi_str_mv | 10.3181/00379727-85-20776 |
| format | Article |
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A chemical separation procedure which yields four arbitrary cell fractions has been developed and applied to three serotypes of leptospires. The four complement-fixing fractions are non-dialyzable, pentose-containing materials, the serological activities of which have been measured semi-quantitatively. One or more complement-fixing principles, of nature not yet known, are concentrated in two chemically distinct, relatively free of protein, polysaccharide-containing cell fractions. The protein constituent (Fraction 3) of the leptospiral cell was poorly reactive in the complement fixation test. Spectrophotometric differences among preparations of Fraction 2 from three serotypes may prove to be an aid in the differentiation of serotypes.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-85-20776</identifier><identifier>PMID: 13134280</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Antibodies ; Antigens ; Complement System Proteins ; Leptospira ; Old Medline</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1954-01, Vol.85 (1), p.32-37</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-30f9106b77e1c9415d8a3d4c99132fbe7f878d1a18535e0ff67a88dc812b695e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13134280$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schneider, Morris D.</creatorcontrib><title>Isolation and Chemical Composition of Complement-Fixing Antigens From Leptospires</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
A chemical separation procedure which yields four arbitrary cell fractions has been developed and applied to three serotypes of leptospires. The four complement-fixing fractions are non-dialyzable, pentose-containing materials, the serological activities of which have been measured semi-quantitatively. One or more complement-fixing principles, of nature not yet known, are concentrated in two chemically distinct, relatively free of protein, polysaccharide-containing cell fractions. The protein constituent (Fraction 3) of the leptospiral cell was poorly reactive in the complement fixation test. Spectrophotometric differences among preparations of Fraction 2 from three serotypes may prove to be an aid in the differentiation of serotypes.</description><subject>Antibodies</subject><subject>Antigens</subject><subject>Complement System Proteins</subject><subject>Leptospira</subject><subject>Old Medline</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1954</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAUxIMo7rr6AbxIT96y5iVtkxyXxdWFBRH0HNL2dc3SNrVpQb-93T_izdPjMb8ZmCHkFthcgIIHxoTUkkuqEsqZlOkZmUIiEipSrc_JdK_TPTAhVyHsGINE8vSSTECAiLliU_K6Dr6yvfNNZJsiWn5g7XJbRUtftz64g-DLw1thjU1PV-7LNdto0fRui02IVp2vow22vQ-t6zBck4vSVgFvTndG3lePb8tnunl5Wi8XG5oLoXoqWKmBpZmUCLmOISmUFUWcaw2ClxnKUklVgAU1FkJWlqm0ShW5Ap6lOkExI_fH3LbznwOG3tQu5FhVtkE_BCOTmHOe8hGEI5h3PoQOS9N2rrbdtwFm9jua3x2NSsxhx9FzdwofshqLP8dpuBGYH4Fgt2h2fuiasew_iT_hH3sM</recordid><startdate>195401</startdate><enddate>195401</enddate><creator>Schneider, Morris D.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195401</creationdate><title>Isolation and Chemical Composition of Complement-Fixing Antigens From Leptospires</title><author>Schneider, Morris D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-30f9106b77e1c9415d8a3d4c99132fbe7f878d1a18535e0ff67a88dc812b695e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1954</creationdate><topic>Antibodies</topic><topic>Antigens</topic><topic>Complement System Proteins</topic><topic>Leptospira</topic><topic>Old Medline</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schneider, Morris D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schneider, Morris D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation and Chemical Composition of Complement-Fixing Antigens From Leptospires</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1954-01</date><risdate>1954</risdate><volume>85</volume><issue>1</issue><spage>32</spage><epage>37</epage><pages>32-37</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
A chemical separation procedure which yields four arbitrary cell fractions has been developed and applied to three serotypes of leptospires. The four complement-fixing fractions are non-dialyzable, pentose-containing materials, the serological activities of which have been measured semi-quantitatively. One or more complement-fixing principles, of nature not yet known, are concentrated in two chemically distinct, relatively free of protein, polysaccharide-containing cell fractions. The protein constituent (Fraction 3) of the leptospiral cell was poorly reactive in the complement fixation test. Spectrophotometric differences among preparations of Fraction 2 from three serotypes may prove to be an aid in the differentiation of serotypes.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13134280</pmid><doi>10.3181/00379727-85-20776</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1954-01, Vol.85 (1), p.32-37 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75422262 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Antibodies Antigens Complement System Proteins Leptospira Old Medline |
| title | Isolation and Chemical Composition of Complement-Fixing Antigens From Leptospires |
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