Suppression of mitogen‐induced peripheral B cell differentiation by soluble Fcγ receptors released from lymphocytes
Soluble receptors for FcIgG released from unstimulated human peripheral blood lymphocytes were isolated by affinity chromatography on Sepharose 4B‐IgG. This material was shown to interfere with the differentiation of peripheral blood B cells into Ig‐secreting cells in cultures stimulated with pokewe...
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| Veröffentlicht in: | European journal of immunology 1980-11, Vol.10 (11), p.894-898 |
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| container_title | European journal of immunology |
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| creator | Lethibichthuy Samarut, Christiane Brochier, Jean Fridman, Wolf Herman Revillard, Jean‐Pierre |
| description | Soluble receptors for FcIgG released from unstimulated human peripheral blood lymphocytes were isolated by affinity chromatography on Sepharose 4B‐IgG. This material was shown to interfere with the differentiation of peripheral blood B cells into Ig‐secreting cells in cultures stimulated with pokeweed or Nocardia opaca extracts. Neither cell viability nor [3H]thymidine incorporation were altered, but the number of Ig‐eontaining cells and that of Ig‐secreting cells were decreased. These effects were dose‐related. They were found to be associated with Fc IgG‐binding soluble material, since absorption on Sepharose 4B‐IgG but not on pepsin‐digested F(ab')2 fragments removed the inhibitory activity. This suppressor factor, released by unstimulated lymphocytes, may represent a human analogue of murine immuno‐globulin‐binding factor (IBF) produced by alloactivated T cells. |
| doi_str_mv | 10.1002/eji.1830101116 |
| format | Article |
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This material was shown to interfere with the differentiation of peripheral blood B cells into Ig‐secreting cells in cultures stimulated with pokeweed or Nocardia opaca extracts. Neither cell viability nor [3H]thymidine incorporation were altered, but the number of Ig‐eontaining cells and that of Ig‐secreting cells were decreased. These effects were dose‐related. They were found to be associated with Fc IgG‐binding soluble material, since absorption on Sepharose 4B‐IgG but not on pepsin‐digested F(ab')2 fragments removed the inhibitory activity. This suppressor factor, released by unstimulated lymphocytes, may represent a human analogue of murine immuno‐globulin‐binding factor (IBF) produced by alloactivated T cells.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830101116</identifier><identifier>PMID: 7007063</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Animals ; B-Lymphocytes - cytology ; Binding Sites ; Cell Differentiation ; Cell Survival ; Hemolytic Plaque Technique ; Humans ; Immunoglobulins - biosynthesis ; Immunosuppression ; Lymphocyte Activation ; Lymphocytes - secretion ; Mice ; Pokeweed Mitogens - pharmacology ; Rabbits ; Receptors, Fc ; Solubility</subject><ispartof>European journal of immunology, 1980-11, Vol.10 (11), p.894-898</ispartof><rights>Copyright © 1980 WILEY‐VCH Verlag GmbH & Co. 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This material was shown to interfere with the differentiation of peripheral blood B cells into Ig‐secreting cells in cultures stimulated with pokeweed or Nocardia opaca extracts. Neither cell viability nor [3H]thymidine incorporation were altered, but the number of Ig‐eontaining cells and that of Ig‐secreting cells were decreased. These effects were dose‐related. They were found to be associated with Fc IgG‐binding soluble material, since absorption on Sepharose 4B‐IgG but not on pepsin‐digested F(ab')2 fragments removed the inhibitory activity. This suppressor factor, released by unstimulated lymphocytes, may represent a human analogue of murine immuno‐globulin‐binding factor (IBF) produced by alloactivated T cells.</description><subject>Animals</subject><subject>B-Lymphocytes - cytology</subject><subject>Binding Sites</subject><subject>Cell Differentiation</subject><subject>Cell Survival</subject><subject>Hemolytic Plaque Technique</subject><subject>Humans</subject><subject>Immunoglobulins - biosynthesis</subject><subject>Immunosuppression</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes - secretion</subject><subject>Mice</subject><subject>Pokeweed Mitogens - pharmacology</subject><subject>Rabbits</subject><subject>Receptors, Fc</subject><subject>Solubility</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1u1TAQhS0Eai-FLbtKXrHL7Uwc52dZqhZaVWIBrCPHHlNXTpzaCSg7HqHv0vfgIXgScnWvgB2rGemc82nmMPYGYYsA-Rnduy3WAhAQsXzGNihzzAos8DnbAGCR5U0Nx-xlSvcA0JSyOWJHFUAFpdiwb5_mcYyUkgsDD5b3bgpfafj149ENZtZk-EjRjXcUlefvuCbvuXHWUqRhcmraxbqFp-DnzhO_0j-feCRN4xRiWjdPKq0QG0PP_dKPd0EvE6VX7IVVPtHrwzxhX64uP198yG4_vr--OL_NtCigzDqsu5rAmkprqEQjoaZSqrwQpuua9Qqja61k11TKiEIqAIuitkUjpJTWGHHC3u65YwwPM6Wp7V3aPaEGCnNqK1nkKCWuxu3eqGNIKZJtx-h6FZcWod0V3a5Ft3-LXgOnB_Lc9WT-2A_Nrnqz1787T8t_aO3lzfU_7N_sH45X</recordid><startdate>198011</startdate><enddate>198011</enddate><creator>Lethibichthuy</creator><creator>Samarut, Christiane</creator><creator>Brochier, Jean</creator><creator>Fridman, Wolf Herman</creator><creator>Revillard, Jean‐Pierre</creator><general>WILEY‐VCH Verlag GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198011</creationdate><title>Suppression of mitogen‐induced peripheral B cell differentiation by soluble Fcγ receptors released from lymphocytes</title><author>Lethibichthuy ; Samarut, Christiane ; Brochier, Jean ; Fridman, Wolf Herman ; Revillard, Jean‐Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3406-b18b8e0fd7cc0739508e65a243dbb9ffedc8ca5b97ad345a00f138f493555fdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>B-Lymphocytes - cytology</topic><topic>Binding Sites</topic><topic>Cell Differentiation</topic><topic>Cell Survival</topic><topic>Hemolytic Plaque Technique</topic><topic>Humans</topic><topic>Immunoglobulins - biosynthesis</topic><topic>Immunosuppression</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes - secretion</topic><topic>Mice</topic><topic>Pokeweed Mitogens - pharmacology</topic><topic>Rabbits</topic><topic>Receptors, Fc</topic><topic>Solubility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lethibichthuy</creatorcontrib><creatorcontrib>Samarut, Christiane</creatorcontrib><creatorcontrib>Brochier, Jean</creatorcontrib><creatorcontrib>Fridman, Wolf Herman</creatorcontrib><creatorcontrib>Revillard, Jean‐Pierre</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lethibichthuy</au><au>Samarut, Christiane</au><au>Brochier, Jean</au><au>Fridman, Wolf Herman</au><au>Revillard, Jean‐Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of mitogen‐induced peripheral B cell differentiation by soluble Fcγ receptors released from lymphocytes</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1980-11</date><risdate>1980</risdate><volume>10</volume><issue>11</issue><spage>894</spage><epage>898</epage><pages>894-898</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>Soluble receptors for FcIgG released from unstimulated human peripheral blood lymphocytes were isolated by affinity chromatography on Sepharose 4B‐IgG. This material was shown to interfere with the differentiation of peripheral blood B cells into Ig‐secreting cells in cultures stimulated with pokeweed or Nocardia opaca extracts. Neither cell viability nor [3H]thymidine incorporation were altered, but the number of Ig‐eontaining cells and that of Ig‐secreting cells were decreased. These effects were dose‐related. They were found to be associated with Fc IgG‐binding soluble material, since absorption on Sepharose 4B‐IgG but not on pepsin‐digested F(ab')2 fragments removed the inhibitory activity. This suppressor factor, released by unstimulated lymphocytes, may represent a human analogue of murine immuno‐globulin‐binding factor (IBF) produced by alloactivated T cells.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>7007063</pmid><doi>10.1002/eji.1830101116</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2980 |
| ispartof | European journal of immunology, 1980-11, Vol.10 (11), p.894-898 |
| issn | 0014-2980 1521-4141 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75421551 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals B-Lymphocytes - cytology Binding Sites Cell Differentiation Cell Survival Hemolytic Plaque Technique Humans Immunoglobulins - biosynthesis Immunosuppression Lymphocyte Activation Lymphocytes - secretion Mice Pokeweed Mitogens - pharmacology Rabbits Receptors, Fc Solubility |
| title | Suppression of mitogen‐induced peripheral B cell differentiation by soluble Fcγ receptors released from lymphocytes |
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