Identification of the Substance Active in Sheep Cell Agglutination Test for Rheumatoid Arthritis
Summary The active principle responsible for sheep cell agglutination test for arthritis was purified and concentrated by salt fractionation and by dialysis against solutions of low ionic strength. The most active fractions were precipitated as plasma was adjusted from a concentration of 9% to a con...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1954-01, Vol.85 (1), p.4-7 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 85 |
| creator | Robinson, Abner R. Stulberg, Cyril S. Kuyper, Adrian C. |
| description | Summary
The active principle responsible for sheep cell agglutination test for arthritis was purified and concentrated by salt fractionation and by dialysis against solutions of low ionic strength. The most active fractions were precipitated as plasma was adjusted from a concentration of 9% to a concentration of 14% sodium sulfate, or from ionic strength 0.06 to ionic strength 0.04. The electrophoretic fraction most consistently present in the concentrate was beta globulin. The agglutination factor is adsorbed on fibrin and is inactivated during lyophilization of concentrates and by the addition of alcohol to arthritic plasma. |
| doi_str_mv | 10.3181/00379727-85-20768 |
| format | Article |
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The active principle responsible for sheep cell agglutination test for arthritis was purified and concentrated by salt fractionation and by dialysis against solutions of low ionic strength. The most active fractions were precipitated as plasma was adjusted from a concentration of 9% to a concentration of 14% sodium sulfate, or from ionic strength 0.06 to ionic strength 0.04. The electrophoretic fraction most consistently present in the concentrate was beta globulin. The agglutination factor is adsorbed on fibrin and is inactivated during lyophilization of concentrates and by the addition of alcohol to arthritic plasma.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-85-20768</identifier><identifier>PMID: 13134272</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Arthritis, Rheumatoid ; Hemagglutination ; Hemagglutination Tests ; Old Medline ; Sheep</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1954-01, Vol.85 (1), p.4-7</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-cb197387af4749418e17ef73a5c6780e70aa6cacc303436282cbe6a3e72a66773</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13134272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Robinson, Abner R.</creatorcontrib><creatorcontrib>Stulberg, Cyril S.</creatorcontrib><creatorcontrib>Kuyper, Adrian C.</creatorcontrib><title>Identification of the Substance Active in Sheep Cell Agglutination Test for Rheumatoid Arthritis</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
The active principle responsible for sheep cell agglutination test for arthritis was purified and concentrated by salt fractionation and by dialysis against solutions of low ionic strength. The most active fractions were precipitated as plasma was adjusted from a concentration of 9% to a concentration of 14% sodium sulfate, or from ionic strength 0.06 to ionic strength 0.04. The electrophoretic fraction most consistently present in the concentrate was beta globulin. The agglutination factor is adsorbed on fibrin and is inactivated during lyophilization of concentrates and by the addition of alcohol to arthritic plasma.</description><subject>Animals</subject><subject>Arthritis, Rheumatoid</subject><subject>Hemagglutination</subject><subject>Hemagglutination Tests</subject><subject>Old Medline</subject><subject>Sheep</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1954</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwA1iQJ7YUO058zlhVfFRCQqJlNo57aV21SbEdJP49KSliY7rhnvfR3UvINWdjwRW_Y0xAASkkKk9SBlKdkCHPRZ4IWRSnZHjYJwdgQC5C2DDGc0jlORlwwUWWQjok77Ml1tFVzprompo2FY1rpPO2DNHUFunERveJ1NV0vkbc0ylut3SyWm3b6Oo-s8AQadV4-rrGdmdi45Z04uPau-jCJTmrzDbg1XGOyNvD_WL6lDy_PM6mk-fECqFiYktegFBgqgyyIuMKOWAFwuRWgmIIzBhpjbWCiUzIVKW2RGkEQmqkBBAjctt79775aLuL9M4F2x1ramzaoCHvpFKJDuQ9aH0TgsdK773bGf-lOdOHWvVvrVrl-qfWLnNzlLflDpd_iWOPHTDugWBWqDdN6-vu2X-M30GFgEE</recordid><startdate>195401</startdate><enddate>195401</enddate><creator>Robinson, Abner R.</creator><creator>Stulberg, Cyril S.</creator><creator>Kuyper, Adrian C.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195401</creationdate><title>Identification of the Substance Active in Sheep Cell Agglutination Test for Rheumatoid Arthritis</title><author>Robinson, Abner R. ; Stulberg, Cyril S. ; Kuyper, Adrian C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-cb197387af4749418e17ef73a5c6780e70aa6cacc303436282cbe6a3e72a66773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1954</creationdate><topic>Animals</topic><topic>Arthritis, Rheumatoid</topic><topic>Hemagglutination</topic><topic>Hemagglutination Tests</topic><topic>Old Medline</topic><topic>Sheep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robinson, Abner R.</creatorcontrib><creatorcontrib>Stulberg, Cyril S.</creatorcontrib><creatorcontrib>Kuyper, Adrian C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robinson, Abner R.</au><au>Stulberg, Cyril S.</au><au>Kuyper, Adrian C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of the Substance Active in Sheep Cell Agglutination Test for Rheumatoid Arthritis</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1954-01</date><risdate>1954</risdate><volume>85</volume><issue>1</issue><spage>4</spage><epage>7</epage><pages>4-7</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
The active principle responsible for sheep cell agglutination test for arthritis was purified and concentrated by salt fractionation and by dialysis against solutions of low ionic strength. The most active fractions were precipitated as plasma was adjusted from a concentration of 9% to a concentration of 14% sodium sulfate, or from ionic strength 0.06 to ionic strength 0.04. The electrophoretic fraction most consistently present in the concentrate was beta globulin. The agglutination factor is adsorbed on fibrin and is inactivated during lyophilization of concentrates and by the addition of alcohol to arthritic plasma.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13134272</pmid><doi>10.3181/00379727-85-20768</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1954-01, Vol.85 (1), p.4-7 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75418683 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Arthritis, Rheumatoid Hemagglutination Hemagglutination Tests Old Medline Sheep |
| title | Identification of the Substance Active in Sheep Cell Agglutination Test for Rheumatoid Arthritis |
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