Calmodulin inhibitors block neutrophil degranulation at a step distal from the mobilization of calcium

Two calmodulin inhibitors, trifluoroperazine and N-(6-aminohexyl-5-chloro-1-naphtalene sulfonamide, were found to be potent inhibitors of the chemotactic factor plus cytochalasin B induced lysosomal enzyme release from rabbit peritoneal neutrophils. On the other hand, these inhibitors did not affect...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical and biophysical research communications 1980-11, Vol.97 (1), p.62-68
Hauptverfasser:	Naccache, P.H., Molski, T.F.P., Alobaidi, T., Becker, E.L., Showell, H.J., Sha'afi, R.I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport, Active - drug effects Calcium - metabolism Calmodulin - antagonists & inhibitors Cytochalasin B - pharmacology Diamines - pharmacology Glucuronidase - metabolism Kinetics Lysosomes - drug effects Lysosomes - enzymology Neutrophils - drug effects Neutrophils - metabolism Rabbits Sulfonamides - pharmacology Trifluoperazine - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!