Effect of papaverine on regional cerebral blood flow and small vessel blood content
The effect of intravenous infusion of papaverine HCl, (2.0–2.5 mg/kg) on regional cerebral blood flow and small vessel blood content in anesthetized rats was determined. Cerebral blood flow was measured in the cerebral cortex, diencephalon plus midbrain, cerebellum, pons and medulla by means of the...
Gespeichert in:
| Veröffentlicht in: | European journal of pharmacology 1980-01, Vol.68 (1), p.17-24 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 24 |
|---|---|
| container_issue | 1 |
| container_start_page | 17 |
| container_title | European journal of pharmacology |
| container_volume | 68 |
| creator | Conway, Robert S. Weiss, Harvey R. |
| description | The effect of intravenous infusion of papaverine HCl, (2.0–2.5 mg/kg) on regional cerebral blood flow and small vessel blood content in anesthetized rats was determined. Cerebral blood flow was measured in the cerebral cortex, diencephalon plus midbrain, cerebellum, pons and medulla by means of the uptake of iodo[
14C]antipyrine. Small vessel blood content was determined by labelling the plasma siderophilin with
59FeCl
3. Cerebral blood flow showed interregional variation under control conditions. Papaverine increased flow in all regions, but the effect was greater in the hind compared to the forebrain. Papaverine did not significantly alter small vessel blood content or calculated open capillary density, indicating it had no functional effect upon cerebral precapillary sphincters, and therefore only affected cerebral arterioles. |
| doi_str_mv | 10.1016/0014-2999(80)90055-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75414685</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0014299980900552</els_id><sourcerecordid>75414685</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-90024fe121e375197d6aaad506048cc58207615929553cfa1a5f2b549abc07ff3</originalsourceid><addsrcrecordid>eNp9kE9LxDAQxYMo67r6DRRyEj1UkzRpmosgy_oHFjyo55CmE6m0TU26K357s-7q0dMMvDczb34InVJyRQktrgmhPGNKqYuSXCpChMjYHprSUqqMSMr20fTPcoiOYnwnyaSYmKCJ5FyVOZ2i54VzYEfsHR7MYNYQmh6w73GAt8b3psUWAlQhNVXrfY1d6z-x6WscO9O2eA0xwq9mfT9CPx6jA2faCCe7OkOvd4uX-UO2fLp_nN8uM5sLOWYpMuMOKKOQS0GVrAtjTC1IQXhprSgZkQVNgZUQuXWGGuFYJbgylSXSuXyGzrd7h-A_VhBH3TXRQtuaHvwqaik45UUpkpFvjTb4GAM4PYSmM-FLU6I3LPUGlN6A0iXRPyw1S2Nnu_2rqoP6b2gHL-k3Wx3Sk-sGgo62gd5C3YTEVNe--f_ANzKjgoA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75414685</pqid></control><display><type>article</type><title>Effect of papaverine on regional cerebral blood flow and small vessel blood content</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Conway, Robert S. ; Weiss, Harvey R.</creator><creatorcontrib>Conway, Robert S. ; Weiss, Harvey R.</creatorcontrib><description>The effect of intravenous infusion of papaverine HCl, (2.0–2.5 mg/kg) on regional cerebral blood flow and small vessel blood content in anesthetized rats was determined. Cerebral blood flow was measured in the cerebral cortex, diencephalon plus midbrain, cerebellum, pons and medulla by means of the uptake of iodo[
14C]antipyrine. Small vessel blood content was determined by labelling the plasma siderophilin with
59FeCl
3. Cerebral blood flow showed interregional variation under control conditions. Papaverine increased flow in all regions, but the effect was greater in the hind compared to the forebrain. Papaverine did not significantly alter small vessel blood content or calculated open capillary density, indicating it had no functional effect upon cerebral precapillary sphincters, and therefore only affected cerebral arterioles.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(80)90055-2</identifier><identifier>PMID: 7449831</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Cerebrovascular Circulation - drug effects ; Intercapillary distance ; Male ; Microcirculation - anatomy & histology ; Microcirculation - drug effects ; Open capillary density ; Papaverine - pharmacology ; Rat brain ; Rats ; Vasodilation</subject><ispartof>European journal of pharmacology, 1980-01, Vol.68 (1), p.17-24</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-90024fe121e375197d6aaad506048cc58207615929553cfa1a5f2b549abc07ff3</citedby><cites>FETCH-LOGICAL-c357t-90024fe121e375197d6aaad506048cc58207615929553cfa1a5f2b549abc07ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014299980900552$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7449831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conway, Robert S.</creatorcontrib><creatorcontrib>Weiss, Harvey R.</creatorcontrib><title>Effect of papaverine on regional cerebral blood flow and small vessel blood content</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The effect of intravenous infusion of papaverine HCl, (2.0–2.5 mg/kg) on regional cerebral blood flow and small vessel blood content in anesthetized rats was determined. Cerebral blood flow was measured in the cerebral cortex, diencephalon plus midbrain, cerebellum, pons and medulla by means of the uptake of iodo[
14C]antipyrine. Small vessel blood content was determined by labelling the plasma siderophilin with
59FeCl
3. Cerebral blood flow showed interregional variation under control conditions. Papaverine increased flow in all regions, but the effect was greater in the hind compared to the forebrain. Papaverine did not significantly alter small vessel blood content or calculated open capillary density, indicating it had no functional effect upon cerebral precapillary sphincters, and therefore only affected cerebral arterioles.</description><subject>Animals</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Intercapillary distance</subject><subject>Male</subject><subject>Microcirculation - anatomy & histology</subject><subject>Microcirculation - drug effects</subject><subject>Open capillary density</subject><subject>Papaverine - pharmacology</subject><subject>Rat brain</subject><subject>Rats</subject><subject>Vasodilation</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMo67r6DRRyEj1UkzRpmosgy_oHFjyo55CmE6m0TU26K357s-7q0dMMvDczb34InVJyRQktrgmhPGNKqYuSXCpChMjYHprSUqqMSMr20fTPcoiOYnwnyaSYmKCJ5FyVOZ2i54VzYEfsHR7MYNYQmh6w73GAt8b3psUWAlQhNVXrfY1d6z-x6WscO9O2eA0xwq9mfT9CPx6jA2faCCe7OkOvd4uX-UO2fLp_nN8uM5sLOWYpMuMOKKOQS0GVrAtjTC1IQXhprSgZkQVNgZUQuXWGGuFYJbgylSXSuXyGzrd7h-A_VhBH3TXRQtuaHvwqaik45UUpkpFvjTb4GAM4PYSmM-FLU6I3LPUGlN6A0iXRPyw1S2Nnu_2rqoP6b2gHL-k3Wx3Sk-sGgo62gd5C3YTEVNe--f_ANzKjgoA</recordid><startdate>19800101</startdate><enddate>19800101</enddate><creator>Conway, Robert S.</creator><creator>Weiss, Harvey R.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19800101</creationdate><title>Effect of papaverine on regional cerebral blood flow and small vessel blood content</title><author>Conway, Robert S. ; Weiss, Harvey R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-90024fe121e375197d6aaad506048cc58207615929553cfa1a5f2b549abc07ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Intercapillary distance</topic><topic>Male</topic><topic>Microcirculation - anatomy & histology</topic><topic>Microcirculation - drug effects</topic><topic>Open capillary density</topic><topic>Papaverine - pharmacology</topic><topic>Rat brain</topic><topic>Rats</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Conway, Robert S.</creatorcontrib><creatorcontrib>Weiss, Harvey R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Conway, Robert S.</au><au>Weiss, Harvey R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of papaverine on regional cerebral blood flow and small vessel blood content</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1980-01-01</date><risdate>1980</risdate><volume>68</volume><issue>1</issue><spage>17</spage><epage>24</epage><pages>17-24</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>The effect of intravenous infusion of papaverine HCl, (2.0–2.5 mg/kg) on regional cerebral blood flow and small vessel blood content in anesthetized rats was determined. Cerebral blood flow was measured in the cerebral cortex, diencephalon plus midbrain, cerebellum, pons and medulla by means of the uptake of iodo[
14C]antipyrine. Small vessel blood content was determined by labelling the plasma siderophilin with
59FeCl
3. Cerebral blood flow showed interregional variation under control conditions. Papaverine increased flow in all regions, but the effect was greater in the hind compared to the forebrain. Papaverine did not significantly alter small vessel blood content or calculated open capillary density, indicating it had no functional effect upon cerebral precapillary sphincters, and therefore only affected cerebral arterioles.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>7449831</pmid><doi>10.1016/0014-2999(80)90055-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1980-01, Vol.68 (1), p.17-24 |
| issn | 0014-2999 1879-0712 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75414685 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cerebrovascular Circulation - drug effects Intercapillary distance Male Microcirculation - anatomy & histology Microcirculation - drug effects Open capillary density Papaverine - pharmacology Rat brain Rats Vasodilation |
| title | Effect of papaverine on regional cerebral blood flow and small vessel blood content |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T11%3A41%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20papaverine%20on%20regional%20cerebral%20blood%20flow%20and%20small%20vessel%20blood%20content&rft.jtitle=European%20journal%20of%20pharmacology&rft.au=Conway,%20Robert%20S.&rft.date=1980-01-01&rft.volume=68&rft.issue=1&rft.spage=17&rft.epage=24&rft.pages=17-24&rft.issn=0014-2999&rft.eissn=1879-0712&rft_id=info:doi/10.1016/0014-2999(80)90055-2&rft_dat=%3Cproquest_cross%3E75414685%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75414685&rft_id=info:pmid/7449831&rft_els_id=0014299980900552&rfr_iscdi=true |