Saponins from Panax japonicus Protect Against Alcohol-Induced Hepatic Injury in Mice by Up-regulating the Expression of GPX3, SOD1 and SOD3

Aims: The purpose of this study was to investigate the possible mechanism(s) of saponins from Panax japonicus (SPJ) on alcohol-induced hepatic damage in mice. Methods: SPJ were identified by high performance liquid chromatography-evaporative light scattering detection-mass spectrometry (LC–ELSD–MS)....

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Veröffentlicht in:	Alcohol and alcoholism (Oxford) 2010-07, Vol.45 (4), p.320-331
Hauptverfasser:	Li, You-Gui, Ji, Dong-Feng, Zhong, Shi, Shi, Lian-Gen, Hu, Gui-Yan, Chen, Shi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Chromatography, High Pressure Liquid Drugs, Chinese Herbal Free Radical Scavengers - chemistry Free Radical Scavengers - isolation & purification Free Radical Scavengers - pharmacology Free Radicals - metabolism Genes Glutathione Peroxidase - genetics Glutathione Peroxidase - metabolism Humans Injuries Lipid Peroxidation - drug effects Liquids Liver - drug effects Liver - enzymology Liver - metabolism Liver Diseases, Alcoholic - prevention & control Male Medical sciences Metabolism Mice Mice, Inbred ICR Panax - chemistry Reactive Oxygen Species - metabolism Reverse Transcriptase Polymerase Chain Reaction Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Spectrometry Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1 Toxicology Up-Regulation - drug effects
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