A Cutaneous Test for Rheumatic Activity in Children
Summary 1. Inunction with an ointment containing 5% tetrahydrofurfuryl ester of nicotinic acid (Trafuril) in 337 children caused localized cutaneous hyperemia and/or edema (“typical” reaction) in normal subjects and those with congenital heart disease or non-rheumatic conditions. 2. Twenty of 22 pat...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1953-12, Vol.84 (3), p.628-631 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 84 |
| creator | Streitfeld, Murray M. Saslaw, Milton S. |
| description | Summary
1. Inunction with an ointment containing 5% tetrahydrofurfuryl ester of nicotinic acid (Trafuril) in 337 children caused localized cutaneous hyperemia and/or edema (“typical” reaction) in normal subjects and those with congenital heart disease or non-rheumatic conditions. 2. Twenty of 22 patients with active rheumatic disease failed to show this typical hyperemia or edema. Their response (“atypical”) consisted of either blanching, failure to react, or barely perceptible hyperemia. 3. Inactive rheumatics and patients whose activity was suppressed by cortisone or aminopyrine gave typical reactions. 4. The atypical response was observed in tonsillitis and streptococcal sore throat, as well as rheumatic activity. |
| doi_str_mv | 10.3181/00379727-84-20734 |
| format | Article |
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1. Inunction with an ointment containing 5% tetrahydrofurfuryl ester of nicotinic acid (Trafuril) in 337 children caused localized cutaneous hyperemia and/or edema (“typical” reaction) in normal subjects and those with congenital heart disease or non-rheumatic conditions. 2. Twenty of 22 patients with active rheumatic disease failed to show this typical hyperemia or edema. Their response (“atypical”) consisted of either blanching, failure to react, or barely perceptible hyperemia. 3. Inactive rheumatics and patients whose activity was suppressed by cortisone or aminopyrine gave typical reactions. 4. The atypical response was observed in tonsillitis and streptococcal sore throat, as well as rheumatic activity.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-84-20734</identifier><identifier>PMID: 13134238</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Furans ; Humans ; Niacin - analogs & derivatives ; Nicotinic Acids ; Old Medline ; Rheumatic Diseases - diagnosis</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1953-12, Vol.84 (3), p.628-631</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-8a2d692ea3284401d79c091e0778741ae6f67830ca63456bb9459d61ab187bfe3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13134238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Streitfeld, Murray M.</creatorcontrib><creatorcontrib>Saslaw, Milton S.</creatorcontrib><title>A Cutaneous Test for Rheumatic Activity in Children</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
1. Inunction with an ointment containing 5% tetrahydrofurfuryl ester of nicotinic acid (Trafuril) in 337 children caused localized cutaneous hyperemia and/or edema (“typical” reaction) in normal subjects and those with congenital heart disease or non-rheumatic conditions. 2. Twenty of 22 patients with active rheumatic disease failed to show this typical hyperemia or edema. Their response (“atypical”) consisted of either blanching, failure to react, or barely perceptible hyperemia. 3. Inactive rheumatics and patients whose activity was suppressed by cortisone or aminopyrine gave typical reactions. 4. The atypical response was observed in tonsillitis and streptococcal sore throat, as well as rheumatic activity.</description><subject>Furans</subject><subject>Humans</subject><subject>Niacin - analogs & derivatives</subject><subject>Nicotinic Acids</subject><subject>Old Medline</subject><subject>Rheumatic Diseases - diagnosis</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1953</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwAWxQVuwCnozjx7KKeEmVkFBZW47j0FR5FDtB6t-TkiJ2rGYx517NHEKugd4hSLinFIUSiYglixMqkJ2QOaSYxsiVOiXzwz4-ADNyEcKWUkhFws_JDBCQJSjnBJdRNvSmdd0QorULfVR2PnrbuKExfWWjpe2rr6rfR1UbZZuqLrxrL8lZaergro5zQd4fH9bZc7x6fXrJlqvYIso-liYpuEqcwUQyRqEQylIFjgohBQPjeMmFRGoNR5byPFcsVQUHk4MUeelwQW6n3p3vPofxNt1Uwbq6ns7VImUAjIkRhAm0vgvBu1LvfNUYv9dA9cGU_jWlJdM_psbMzbF8yBtX_CWOakbgbgKC-XB62w2-HZ_9p_Eb8zVusg</recordid><startdate>195312</startdate><enddate>195312</enddate><creator>Streitfeld, Murray M.</creator><creator>Saslaw, Milton S.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195312</creationdate><title>A Cutaneous Test for Rheumatic Activity in Children</title><author>Streitfeld, Murray M. ; Saslaw, Milton S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-8a2d692ea3284401d79c091e0778741ae6f67830ca63456bb9459d61ab187bfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1953</creationdate><topic>Furans</topic><topic>Humans</topic><topic>Niacin - analogs & derivatives</topic><topic>Nicotinic Acids</topic><topic>Old Medline</topic><topic>Rheumatic Diseases - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Streitfeld, Murray M.</creatorcontrib><creatorcontrib>Saslaw, Milton S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Streitfeld, Murray M.</au><au>Saslaw, Milton S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Cutaneous Test for Rheumatic Activity in Children</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1953-12</date><risdate>1953</risdate><volume>84</volume><issue>3</issue><spage>628</spage><epage>631</epage><pages>628-631</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
1. Inunction with an ointment containing 5% tetrahydrofurfuryl ester of nicotinic acid (Trafuril) in 337 children caused localized cutaneous hyperemia and/or edema (“typical” reaction) in normal subjects and those with congenital heart disease or non-rheumatic conditions. 2. Twenty of 22 patients with active rheumatic disease failed to show this typical hyperemia or edema. Their response (“atypical”) consisted of either blanching, failure to react, or barely perceptible hyperemia. 3. Inactive rheumatics and patients whose activity was suppressed by cortisone or aminopyrine gave typical reactions. 4. The atypical response was observed in tonsillitis and streptococcal sore throat, as well as rheumatic activity.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13134238</pmid><doi>10.3181/00379727-84-20734</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1953-12, Vol.84 (3), p.628-631 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75411447 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Furans Humans Niacin - analogs & derivatives Nicotinic Acids Old Medline Rheumatic Diseases - diagnosis |
| title | A Cutaneous Test for Rheumatic Activity in Children |
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