Biochemical changes in neurosurgical patients under critical care treated with mannitol

A Study was carried out on ten patients undergoing operations for brain tumors, who were treated with mannitol solutions. This caused a significant depletion of serum sodium ion and an increase of discriminate osmolality (to 60 mosM/kg H20). A hypothesis about the particular biochemical mechanism, i...

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Veröffentlicht in:	Resuscitation 1980-06, Vol.8 (2), p.95-100
Hauptverfasser:	Bracall, A.M., Zanghi, F., Sabato, A.F., De Francisci, G., Bondoli, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-Base Equilibrium - drug effects Blood Gas Analysis Brain Neoplasms - metabolism Brain Neoplasms - surgery Humans Mannitol - therapeutic use Osmolar Concentration Potassium - metabolism Premedication Sodium - metabolism
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Beschreibung
Zusammenfassung:	A Study was carried out on ten patients undergoing operations for brain tumors, who were treated with mannitol solutions. This caused a significant depletion of serum sodium ion and an increase of discriminate osmolality (to 60 mosM/kg H20). A hypothesis about the particular biochemical mechanism, involving the electrolyte and water distribution, is presented.
ISSN:	0300-9572 1873-1570
DOI:	10.1016/0300-9572(80)90015-5