Serotonergic and catecholaminergic influence on thyroid function in the vervet monkey

Vervet monkeys were pharmacologically treated acutely and with repeated dose loading to alter serotonergic systems to assess the role of serotonin in the regulation of the hypothalamus-pituitary-thyroid axis. Acute L-tryptophan administration failed to alter basal levels of thyroid hormones but did...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of pharmacology 1980-01, Vol.67 (2), p.283-288
Hauptverfasser: Morley, J.E., Raleigh, M.J., Brammer, G.L., Yuwiler, A., Geller, E., Flannery, J., Hershman, J.M.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 288
container_issue 2
container_start_page 283
container_title European journal of pharmacology
container_volume 67
creator Morley, J.E.
Raleigh, M.J.
Brammer, G.L.
Yuwiler, A.
Geller, E.
Flannery, J.
Hershman, J.M.
description Vervet monkeys were pharmacologically treated acutely and with repeated dose loading to alter serotonergic systems to assess the role of serotonin in the regulation of the hypothalamus-pituitary-thyroid axis. Acute L-tryptophan administration failed to alter basal levels of thyroid hormones but did decrease the TRH-induced TSH response. Repeated dose loading of tryptophan or 5-hydroxytryptophan increased blood serotonin and plasma T3 and decreased plasma TSH. The tryptophan hydroxylase inhibitor p-chlorophenylalanine yielded decreased blood serotonin, but did not affect plasma TSH, T4 or T3. The monoamine oxidase inhibitor chlorgyline also resulted in increased blood serotonin, but increased plasma TSH and T4 and decreased T3. These data may be explained by a unitary hypothesis involving central catecholaminergic, rather than serotonergic, control of TRH release. Chlorgyline may produce its effects predominantly by facilitating catecholaminergic stimulation of TRH release resulting in increased TSH and a consequent increase in T4. It is suggested that the effects of tryptophan and 5-hydroxytryptophan result from increases in serotonin levels in the thyroid gland to produce an increase in T3 with a compensatory decrease in TSH via negative feedback. The differences observed between the acute and repeated dose loading studies stress the need for both types of studies before drawing conclusions about the effects of pharmacological manipulations on hormonal levels.
doi_str_mv 10.1016/0014-2999(80)90509-9
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75405687</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0014299980905099</els_id><sourcerecordid>75405687</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-d7ee81349612df49fbe2450bd798098151a8781c4a1cb73c54db29643c39809e3</originalsourceid><addsrcrecordid>eNp9kM1LxDAQxYMo6_rxHyj0JHqoTtqkSS6CLH6B4EH3HNpkqtG20aRd2P_e1l08ehp4894b5kfICYVLCrS4AqAszZRS5xIuFHBQqdohcyqFSkHQbJfM_yz75CDGDwDgKuMzMiuEhFzAnCxfMPjedxjenEnKziam7NG8-6Zs3VZ1Xd0M2BlMfJf07-vgnU3qoTO9GwU3aZisMKywT1rffeL6iOzVZRPxeDsPyfLu9nXxkD493z8ubp5Sk3PRp1YgSpozVdDM1kzVFWaMQ2WFkqAk5bSUQlLDSmoqkRvObJWpguUmnwyYH5KzTe9X8N8Dxl63LhpsmrJDP0QtOANeSDEa2cZogo8xYK2_gmvLsNYU9ERTT6j0hEpL0L80tRpjp9v-oWrR_oW2-Mb99WaP45Mrh0FH4yZS1gU0vbbe_X_gB-HBhEA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75405687</pqid></control><display><type>article</type><title>Serotonergic and catecholaminergic influence on thyroid function in the vervet monkey</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Morley, J.E. ; Raleigh, M.J. ; Brammer, G.L. ; Yuwiler, A. ; Geller, E. ; Flannery, J. ; Hershman, J.M.</creator><creatorcontrib>Morley, J.E. ; Raleigh, M.J. ; Brammer, G.L. ; Yuwiler, A. ; Geller, E. ; Flannery, J. ; Hershman, J.M.</creatorcontrib><description>Vervet monkeys were pharmacologically treated acutely and with repeated dose loading to alter serotonergic systems to assess the role of serotonin in the regulation of the hypothalamus-pituitary-thyroid axis. Acute L-tryptophan administration failed to alter basal levels of thyroid hormones but did decrease the TRH-induced TSH response. Repeated dose loading of tryptophan or 5-hydroxytryptophan increased blood serotonin and plasma T3 and decreased plasma TSH. The tryptophan hydroxylase inhibitor p-chlorophenylalanine yielded decreased blood serotonin, but did not affect plasma TSH, T4 or T3. The monoamine oxidase inhibitor chlorgyline also resulted in increased blood serotonin, but increased plasma TSH and T4 and decreased T3. These data may be explained by a unitary hypothesis involving central catecholaminergic, rather than serotonergic, control of TRH release. Chlorgyline may produce its effects predominantly by facilitating catecholaminergic stimulation of TRH release resulting in increased TSH and a consequent increase in T4. It is suggested that the effects of tryptophan and 5-hydroxytryptophan result from increases in serotonin levels in the thyroid gland to produce an increase in T3 with a compensatory decrease in TSH via negative feedback. The differences observed between the acute and repeated dose loading studies stress the need for both types of studies before drawing conclusions about the effects of pharmacological manipulations on hormonal levels.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(80)90509-9</identifier><identifier>PMID: 6780370</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>5-Hydroxytryptophan - pharmacology ; Animals ; Catecholamines - physiology ; Cercopithecus aethiops ; Chlorgyline ; Clorgyline - pharmacology ; Female ; Hypothalamo-Hypophyseal System - physiology ; Male ; Serotonin - blood ; Serotonin - physiology ; Thyroid Gland - physiology ; Thyroid Hormones - blood ; Thyrotropin ; Thyrotropin - metabolism ; Thyrotropin releasing hormone ; Thyrotropin-Releasing Hormone - metabolism ; Tryptophan - pharmacology</subject><ispartof>European journal of pharmacology, 1980-01, Vol.67 (2), p.283-288</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-d7ee81349612df49fbe2450bd798098151a8781c4a1cb73c54db29643c39809e3</citedby><cites>FETCH-LOGICAL-c357t-d7ee81349612df49fbe2450bd798098151a8781c4a1cb73c54db29643c39809e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(80)90509-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6780370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morley, J.E.</creatorcontrib><creatorcontrib>Raleigh, M.J.</creatorcontrib><creatorcontrib>Brammer, G.L.</creatorcontrib><creatorcontrib>Yuwiler, A.</creatorcontrib><creatorcontrib>Geller, E.</creatorcontrib><creatorcontrib>Flannery, J.</creatorcontrib><creatorcontrib>Hershman, J.M.</creatorcontrib><title>Serotonergic and catecholaminergic influence on thyroid function in the vervet monkey</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Vervet monkeys were pharmacologically treated acutely and with repeated dose loading to alter serotonergic systems to assess the role of serotonin in the regulation of the hypothalamus-pituitary-thyroid axis. Acute L-tryptophan administration failed to alter basal levels of thyroid hormones but did decrease the TRH-induced TSH response. Repeated dose loading of tryptophan or 5-hydroxytryptophan increased blood serotonin and plasma T3 and decreased plasma TSH. The tryptophan hydroxylase inhibitor p-chlorophenylalanine yielded decreased blood serotonin, but did not affect plasma TSH, T4 or T3. The monoamine oxidase inhibitor chlorgyline also resulted in increased blood serotonin, but increased plasma TSH and T4 and decreased T3. These data may be explained by a unitary hypothesis involving central catecholaminergic, rather than serotonergic, control of TRH release. Chlorgyline may produce its effects predominantly by facilitating catecholaminergic stimulation of TRH release resulting in increased TSH and a consequent increase in T4. It is suggested that the effects of tryptophan and 5-hydroxytryptophan result from increases in serotonin levels in the thyroid gland to produce an increase in T3 with a compensatory decrease in TSH via negative feedback. The differences observed between the acute and repeated dose loading studies stress the need for both types of studies before drawing conclusions about the effects of pharmacological manipulations on hormonal levels.</description><subject>5-Hydroxytryptophan - pharmacology</subject><subject>Animals</subject><subject>Catecholamines - physiology</subject><subject>Cercopithecus aethiops</subject><subject>Chlorgyline</subject><subject>Clorgyline - pharmacology</subject><subject>Female</subject><subject>Hypothalamo-Hypophyseal System - physiology</subject><subject>Male</subject><subject>Serotonin - blood</subject><subject>Serotonin - physiology</subject><subject>Thyroid Gland - physiology</subject><subject>Thyroid Hormones - blood</subject><subject>Thyrotropin</subject><subject>Thyrotropin - metabolism</subject><subject>Thyrotropin releasing hormone</subject><subject>Thyrotropin-Releasing Hormone - metabolism</subject><subject>Tryptophan - pharmacology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LxDAQxYMo6_rxHyj0JHqoTtqkSS6CLH6B4EH3HNpkqtG20aRd2P_e1l08ehp4894b5kfICYVLCrS4AqAszZRS5xIuFHBQqdohcyqFSkHQbJfM_yz75CDGDwDgKuMzMiuEhFzAnCxfMPjedxjenEnKziam7NG8-6Zs3VZ1Xd0M2BlMfJf07-vgnU3qoTO9GwU3aZisMKywT1rffeL6iOzVZRPxeDsPyfLu9nXxkD493z8ubp5Sk3PRp1YgSpozVdDM1kzVFWaMQ2WFkqAk5bSUQlLDSmoqkRvObJWpguUmnwyYH5KzTe9X8N8Dxl63LhpsmrJDP0QtOANeSDEa2cZogo8xYK2_gmvLsNYU9ERTT6j0hEpL0L80tRpjp9v-oWrR_oW2-Mb99WaP45Mrh0FH4yZS1gU0vbbe_X_gB-HBhEA</recordid><startdate>19800101</startdate><enddate>19800101</enddate><creator>Morley, J.E.</creator><creator>Raleigh, M.J.</creator><creator>Brammer, G.L.</creator><creator>Yuwiler, A.</creator><creator>Geller, E.</creator><creator>Flannery, J.</creator><creator>Hershman, J.M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19800101</creationdate><title>Serotonergic and catecholaminergic influence on thyroid function in the vervet monkey</title><author>Morley, J.E. ; Raleigh, M.J. ; Brammer, G.L. ; Yuwiler, A. ; Geller, E. ; Flannery, J. ; Hershman, J.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-d7ee81349612df49fbe2450bd798098151a8781c4a1cb73c54db29643c39809e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>5-Hydroxytryptophan - pharmacology</topic><topic>Animals</topic><topic>Catecholamines - physiology</topic><topic>Cercopithecus aethiops</topic><topic>Chlorgyline</topic><topic>Clorgyline - pharmacology</topic><topic>Female</topic><topic>Hypothalamo-Hypophyseal System - physiology</topic><topic>Male</topic><topic>Serotonin - blood</topic><topic>Serotonin - physiology</topic><topic>Thyroid Gland - physiology</topic><topic>Thyroid Hormones - blood</topic><topic>Thyrotropin</topic><topic>Thyrotropin - metabolism</topic><topic>Thyrotropin releasing hormone</topic><topic>Thyrotropin-Releasing Hormone - metabolism</topic><topic>Tryptophan - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morley, J.E.</creatorcontrib><creatorcontrib>Raleigh, M.J.</creatorcontrib><creatorcontrib>Brammer, G.L.</creatorcontrib><creatorcontrib>Yuwiler, A.</creatorcontrib><creatorcontrib>Geller, E.</creatorcontrib><creatorcontrib>Flannery, J.</creatorcontrib><creatorcontrib>Hershman, J.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morley, J.E.</au><au>Raleigh, M.J.</au><au>Brammer, G.L.</au><au>Yuwiler, A.</au><au>Geller, E.</au><au>Flannery, J.</au><au>Hershman, J.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotonergic and catecholaminergic influence on thyroid function in the vervet monkey</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1980-01-01</date><risdate>1980</risdate><volume>67</volume><issue>2</issue><spage>283</spage><epage>288</epage><pages>283-288</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Vervet monkeys were pharmacologically treated acutely and with repeated dose loading to alter serotonergic systems to assess the role of serotonin in the regulation of the hypothalamus-pituitary-thyroid axis. Acute L-tryptophan administration failed to alter basal levels of thyroid hormones but did decrease the TRH-induced TSH response. Repeated dose loading of tryptophan or 5-hydroxytryptophan increased blood serotonin and plasma T3 and decreased plasma TSH. The tryptophan hydroxylase inhibitor p-chlorophenylalanine yielded decreased blood serotonin, but did not affect plasma TSH, T4 or T3. The monoamine oxidase inhibitor chlorgyline also resulted in increased blood serotonin, but increased plasma TSH and T4 and decreased T3. These data may be explained by a unitary hypothesis involving central catecholaminergic, rather than serotonergic, control of TRH release. Chlorgyline may produce its effects predominantly by facilitating catecholaminergic stimulation of TRH release resulting in increased TSH and a consequent increase in T4. It is suggested that the effects of tryptophan and 5-hydroxytryptophan result from increases in serotonin levels in the thyroid gland to produce an increase in T3 with a compensatory decrease in TSH via negative feedback. The differences observed between the acute and repeated dose loading studies stress the need for both types of studies before drawing conclusions about the effects of pharmacological manipulations on hormonal levels.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>6780370</pmid><doi>10.1016/0014-2999(80)90509-9</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0014-2999
ispartof European journal of pharmacology, 1980-01, Vol.67 (2), p.283-288
issn 0014-2999
1879-0712
language eng
recordid cdi_proquest_miscellaneous_75405687
source MEDLINE; Access via ScienceDirect (Elsevier)
subjects 5-Hydroxytryptophan - pharmacology
Animals
Catecholamines - physiology
Cercopithecus aethiops
Chlorgyline
Clorgyline - pharmacology
Female
Hypothalamo-Hypophyseal System - physiology
Male
Serotonin - blood
Serotonin - physiology
Thyroid Gland - physiology
Thyroid Hormones - blood
Thyrotropin
Thyrotropin - metabolism
Thyrotropin releasing hormone
Thyrotropin-Releasing Hormone - metabolism
Tryptophan - pharmacology
title Serotonergic and catecholaminergic influence on thyroid function in the vervet monkey
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T22%3A09%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serotonergic%20and%20catecholaminergic%20influence%20on%20thyroid%20function%20in%20the%20vervet%20monkey&rft.jtitle=European%20journal%20of%20pharmacology&rft.au=Morley,%20J.E.&rft.date=1980-01-01&rft.volume=67&rft.issue=2&rft.spage=283&rft.epage=288&rft.pages=283-288&rft.issn=0014-2999&rft.eissn=1879-0712&rft_id=info:doi/10.1016/0014-2999(80)90509-9&rft_dat=%3Cproquest_cross%3E75405687%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75405687&rft_id=info:pmid/6780370&rft_els_id=0014299980905099&rfr_iscdi=true