Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells

the aims of the study are to investigate the additive effect of exogenous short-carbon chain phospholipids, C(2)-ceramide, on an anti-cancer drug paclitaxel (PTX)-induced senescence of human non-small cell lung cancer (NSCLC) cells deficient in functional p53 and p16, and to examine whether mitogen-...

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Veröffentlicht in:	Life sciences (1973) 2010-09, Vol.87 (11-12), p.350-357
Hauptverfasser:	Chen, Jeff Yi-Fu, Hwang, Chi-Ching, Chen, Wei-Yi, Lee, Jing-Ching, Fu, Tzu-Fun, Fang, Kang, Chu, Ying-Chieh, Huang, Ya-Lan, Lin, Jia-Cheng, Tsai, Wen-Hui, Chang, Hsueh-Wei, Chen, Bing-Hung, Chiu, Chien-Chih
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Baculoviral IAP Repeat-Containing 3 Protein beta-Galactosidase - metabolism Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Caspase 3 - metabolism Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cell Survival - genetics Cellular Senescence - drug effects Cyclin-Dependent Kinase Inhibitor p21 - genetics DNA Fragmentation - drug effects Extracellular Signal-Regulated MAP Kinases - metabolism G2 Phase - drug effects Gene Expression - drug effects Gene Expression - genetics GTP-Binding Proteins - genetics Humans Inhibitor of Apoptosis Proteins - genetics JNK Mitogen-Activated Protein Kinases - metabolism Microfilament Proteins - genetics Muscle Proteins - genetics Osteonectin - genetics p38 Mitogen-Activated Protein Kinases - metabolism Paclitaxel - pharmacology Phosphorylation - drug effects Plasminogen Activator Inhibitor 1 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Sphingosine - analogs & derivatives Sphingosine - pharmacology Transglutaminases - genetics Ubiquitin-Protein Ligases
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