Increasing Donor Body Weight to Prevent Small-for-Size Syndrome in Living Donor Liver Transplantation
Background This study was designed to evaluate the possibility of avoiding small-for-size syndrome (SFSS) in living donor liver transplantation (LDLT) by increasing the donor’s body weight (BW) before liver donation. Methods Nineteen participants, including 15 volunteers and 4 liver donors, were enr...
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| Veröffentlicht in: | World journal of surgery 2010-10, Vol.34 (10), p.2401-2408 |
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| creator | Liu, Chinsu Lee, Rheun-Chuan Loong, Che-Chuan Hsia, Cheng-Yuan Yeh, Yi-Chen Chiou, See-Ying |
| description | Background
This study was designed to evaluate the possibility of avoiding small-for-size syndrome (SFSS) in living donor liver transplantation (LDLT) by increasing the donor’s body weight (BW) before liver donation.
Methods
Nineteen participants, including 15 volunteers and 4 liver donors, were enrolled in this study to increase their BW by 1.5–5 kg within 3 months by eating a high-protein and high-carbohydrate diet according to a flexible formula to increase calorie intake.
Results
Fifteen participants, including 12 volunteers and 3 live liver donors, successfully increased their BW by 1.5–5 kg within 3 months (failure rate, 21%). The actual liver weight (LW) gain was more than the expected LW gain using the formula for calculating standard liver volume (2.77- to 8.94-fold; median, 4.49-fold; mean, 4.45-fold,
P
|
| doi_str_mv | 10.1007/s00268-010-0656-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_754030383</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>754030383</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4500-9d9a88a5488d10b482e9dbfeab729fdcf89c2c50c8eca720eb8e5bf4cddabe813</originalsourceid><addsrcrecordid>eNqFkV1rFDEUhoModlv9Ad5IEKRXoycfM5O5tNVqZUFhK70MmcyZNWUm2SazlfXXm2VWFwTxKiec5z1fLyEvGLxhAPXbBMArVQCDAqqyKuQjsmBS8IILLh6TBYhK5piJE3Ka0h0AqyuonpITDqUQObsgeO1tRJOcX9P3wYdIL0K3o7fo1t8nOgX6NeID-omuRjMMRR9isXI_ka52vothROo8XbqHozx_MNKbaHzaDMZPZnLBPyNPejMkfH54z8i3qw83l5-K5ZeP15fvloWVJUDRdI1RypRSqY5BKxXHpmt7NG3Nm76zvWostyVYhdbUHLBVWLa9tF1nWlRMnJHzue4mhvstpkmPLlkc8iAYtknXpYS8txKZfPUXeRe20efhMsQ4qxiXGWIzZGNIKWKvN9GNJu40A713QM8O6OyA3jug95qXh8LbdsTuj-L3yTPw-gCYZM3Q50tZl46cELm3UplrZu6HG3D3_8769vPq4grKnM1aPmtTlvk1xuN2_578F71Gr1I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>751216124</pqid></control><display><type>article</type><title>Increasing Donor Body Weight to Prevent Small-for-Size Syndrome in Living Donor Liver Transplantation</title><source>MEDLINE</source><source>Wiley Journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Liu, Chinsu ; Lee, Rheun-Chuan ; Loong, Che-Chuan ; Hsia, Cheng-Yuan ; Yeh, Yi-Chen ; Chiou, See-Ying</creator><creatorcontrib>Liu, Chinsu ; Lee, Rheun-Chuan ; Loong, Che-Chuan ; Hsia, Cheng-Yuan ; Yeh, Yi-Chen ; Chiou, See-Ying</creatorcontrib><description>Background
This study was designed to evaluate the possibility of avoiding small-for-size syndrome (SFSS) in living donor liver transplantation (LDLT) by increasing the donor’s body weight (BW) before liver donation.
Methods
Nineteen participants, including 15 volunteers and 4 liver donors, were enrolled in this study to increase their BW by 1.5–5 kg within 3 months by eating a high-protein and high-carbohydrate diet according to a flexible formula to increase calorie intake.
Results
Fifteen participants, including 12 volunteers and 3 live liver donors, successfully increased their BW by 1.5–5 kg within 3 months (failure rate, 21%). The actual liver weight (LW) gain was more than the expected LW gain using the formula for calculating standard liver volume (2.77- to 8.94-fold; median, 4.49-fold; mean, 4.45-fold,
P
< 0.005) and using the ratio of liver weight to body weight (1.36- to 4.49-fold; median, 2.01-fold; mean, 2.06-fold,
P
< 0.005). The enlargement of the livers was symmetrical without significant fatty change. The graft-versus-recipient weight ratio increased 0.17%, 0.07%, and 0.08%, respectively, for the three live liver donors and successful LDLTs were performed.
Conclusions
By having liver donors eat a high-protein, high-carbohydrate diet to increase their BW in a short period of time, the actual LW may increase more than the expected LW gain without fatty change. This method of increasing LW may be used in selected cases of LDLT to avoid SFSS.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-010-0656-4</identifier><identifier>PMID: 20533036</identifier><identifier>CODEN: WJSUDI</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Abdominal Surgery ; Adult ; Biological and medical sciences ; Body Weight ; Body Weight Gain ; Cardiac Surgery ; Female ; General aspects ; General Surgery ; Humans ; Live Donor Liver Transplantation ; Liver Diseases - surgery ; Liver Donor ; Liver Graft ; Liver Transplantation - adverse effects ; Liver Transplantation - methods ; Liver Volume ; Liver, biliary tract, pancreas, portal circulation, spleen ; Living Donors ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Organ Size ; Postoperative Complications - etiology ; Postoperative Complications - prevention & control ; Prevention and actions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Thoracic Surgery ; Vascular Surgery ; Weight Gain</subject><ispartof>World journal of surgery, 2010-10, Vol.34 (10), p.2401-2408</ispartof><rights>Société Internationale de Chirurgie 2010</rights><rights>2010 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4500-9d9a88a5488d10b482e9dbfeab729fdcf89c2c50c8eca720eb8e5bf4cddabe813</citedby><cites>FETCH-LOGICAL-c4500-9d9a88a5488d10b482e9dbfeab729fdcf89c2c50c8eca720eb8e5bf4cddabe813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-010-0656-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-010-0656-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,41488,42557,45574,45575,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23361288$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20533036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Chinsu</creatorcontrib><creatorcontrib>Lee, Rheun-Chuan</creatorcontrib><creatorcontrib>Loong, Che-Chuan</creatorcontrib><creatorcontrib>Hsia, Cheng-Yuan</creatorcontrib><creatorcontrib>Yeh, Yi-Chen</creatorcontrib><creatorcontrib>Chiou, See-Ying</creatorcontrib><title>Increasing Donor Body Weight to Prevent Small-for-Size Syndrome in Living Donor Liver Transplantation</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description>Background
This study was designed to evaluate the possibility of avoiding small-for-size syndrome (SFSS) in living donor liver transplantation (LDLT) by increasing the donor’s body weight (BW) before liver donation.
Methods
Nineteen participants, including 15 volunteers and 4 liver donors, were enrolled in this study to increase their BW by 1.5–5 kg within 3 months by eating a high-protein and high-carbohydrate diet according to a flexible formula to increase calorie intake.
Results
Fifteen participants, including 12 volunteers and 3 live liver donors, successfully increased their BW by 1.5–5 kg within 3 months (failure rate, 21%). The actual liver weight (LW) gain was more than the expected LW gain using the formula for calculating standard liver volume (2.77- to 8.94-fold; median, 4.49-fold; mean, 4.45-fold,
P
< 0.005) and using the ratio of liver weight to body weight (1.36- to 4.49-fold; median, 2.01-fold; mean, 2.06-fold,
P
< 0.005). The enlargement of the livers was symmetrical without significant fatty change. The graft-versus-recipient weight ratio increased 0.17%, 0.07%, and 0.08%, respectively, for the three live liver donors and successful LDLTs were performed.
Conclusions
By having liver donors eat a high-protein, high-carbohydrate diet to increase their BW in a short period of time, the actual LW may increase more than the expected LW gain without fatty change. This method of increasing LW may be used in selected cases of LDLT to avoid SFSS.</description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Body Weight Gain</subject><subject>Cardiac Surgery</subject><subject>Female</subject><subject>General aspects</subject><subject>General Surgery</subject><subject>Humans</subject><subject>Live Donor Liver Transplantation</subject><subject>Liver Diseases - surgery</subject><subject>Liver Donor</subject><subject>Liver Graft</subject><subject>Liver Transplantation - adverse effects</subject><subject>Liver Transplantation - methods</subject><subject>Liver Volume</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Living Donors</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Organ Size</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - prevention & control</subject><subject>Prevention and actions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Thoracic Surgery</subject><subject>Vascular Surgery</subject><subject>Weight Gain</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkV1rFDEUhoModlv9Ad5IEKRXoycfM5O5tNVqZUFhK70MmcyZNWUm2SazlfXXm2VWFwTxKiec5z1fLyEvGLxhAPXbBMArVQCDAqqyKuQjsmBS8IILLh6TBYhK5piJE3Ka0h0AqyuonpITDqUQObsgeO1tRJOcX9P3wYdIL0K3o7fo1t8nOgX6NeID-omuRjMMRR9isXI_ka52vothROo8XbqHozx_MNKbaHzaDMZPZnLBPyNPejMkfH54z8i3qw83l5-K5ZeP15fvloWVJUDRdI1RypRSqY5BKxXHpmt7NG3Nm76zvWostyVYhdbUHLBVWLa9tF1nWlRMnJHzue4mhvstpkmPLlkc8iAYtknXpYS8txKZfPUXeRe20efhMsQ4qxiXGWIzZGNIKWKvN9GNJu40A713QM8O6OyA3jug95qXh8LbdsTuj-L3yTPw-gCYZM3Q50tZl46cELm3UplrZu6HG3D3_8769vPq4grKnM1aPmtTlvk1xuN2_578F71Gr1I</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Liu, Chinsu</creator><creator>Lee, Rheun-Chuan</creator><creator>Loong, Che-Chuan</creator><creator>Hsia, Cheng-Yuan</creator><creator>Yeh, Yi-Chen</creator><creator>Chiou, See-Ying</creator><general>Springer-Verlag</general><general>Springer‐Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>201010</creationdate><title>Increasing Donor Body Weight to Prevent Small-for-Size Syndrome in Living Donor Liver Transplantation</title><author>Liu, Chinsu ; Lee, Rheun-Chuan ; Loong, Che-Chuan ; Hsia, Cheng-Yuan ; Yeh, Yi-Chen ; Chiou, See-Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4500-9d9a88a5488d10b482e9dbfeab729fdcf89c2c50c8eca720eb8e5bf4cddabe813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Body Weight Gain</topic><topic>Cardiac Surgery</topic><topic>Female</topic><topic>General aspects</topic><topic>General Surgery</topic><topic>Humans</topic><topic>Live Donor Liver Transplantation</topic><topic>Liver Diseases - surgery</topic><topic>Liver Donor</topic><topic>Liver Graft</topic><topic>Liver Transplantation - adverse effects</topic><topic>Liver Transplantation - methods</topic><topic>Liver Volume</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Living Donors</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Organ Size</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - prevention & control</topic><topic>Prevention and actions</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Thoracic Surgery</topic><topic>Vascular Surgery</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Chinsu</creatorcontrib><creatorcontrib>Lee, Rheun-Chuan</creatorcontrib><creatorcontrib>Loong, Che-Chuan</creatorcontrib><creatorcontrib>Hsia, Cheng-Yuan</creatorcontrib><creatorcontrib>Yeh, Yi-Chen</creatorcontrib><creatorcontrib>Chiou, See-Ying</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Chinsu</au><au>Lee, Rheun-Chuan</au><au>Loong, Che-Chuan</au><au>Hsia, Cheng-Yuan</au><au>Yeh, Yi-Chen</au><au>Chiou, See-Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increasing Donor Body Weight to Prevent Small-for-Size Syndrome in Living Donor Liver Transplantation</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><addtitle>World J Surg</addtitle><date>2010-10</date><risdate>2010</risdate><volume>34</volume><issue>10</issue><spage>2401</spage><epage>2408</epage><pages>2401-2408</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><coden>WJSUDI</coden><abstract>Background
This study was designed to evaluate the possibility of avoiding small-for-size syndrome (SFSS) in living donor liver transplantation (LDLT) by increasing the donor’s body weight (BW) before liver donation.
Methods
Nineteen participants, including 15 volunteers and 4 liver donors, were enrolled in this study to increase their BW by 1.5–5 kg within 3 months by eating a high-protein and high-carbohydrate diet according to a flexible formula to increase calorie intake.
Results
Fifteen participants, including 12 volunteers and 3 live liver donors, successfully increased their BW by 1.5–5 kg within 3 months (failure rate, 21%). The actual liver weight (LW) gain was more than the expected LW gain using the formula for calculating standard liver volume (2.77- to 8.94-fold; median, 4.49-fold; mean, 4.45-fold,
P
< 0.005) and using the ratio of liver weight to body weight (1.36- to 4.49-fold; median, 2.01-fold; mean, 2.06-fold,
P
< 0.005). The enlargement of the livers was symmetrical without significant fatty change. The graft-versus-recipient weight ratio increased 0.17%, 0.07%, and 0.08%, respectively, for the three live liver donors and successful LDLTs were performed.
Conclusions
By having liver donors eat a high-protein, high-carbohydrate diet to increase their BW in a short period of time, the actual LW may increase more than the expected LW gain without fatty change. This method of increasing LW may be used in selected cases of LDLT to avoid SFSS.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>20533036</pmid><doi>10.1007/s00268-010-0656-4</doi><tpages>8</tpages></addata></record> |
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| subjects | Abdominal Surgery Adult Biological and medical sciences Body Weight Body Weight Gain Cardiac Surgery Female General aspects General Surgery Humans Live Donor Liver Transplantation Liver Diseases - surgery Liver Donor Liver Graft Liver Transplantation - adverse effects Liver Transplantation - methods Liver Volume Liver, biliary tract, pancreas, portal circulation, spleen Living Donors Male Medical sciences Medicine Medicine & Public Health Middle Aged Organ Size Postoperative Complications - etiology Postoperative Complications - prevention & control Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Thoracic Surgery Vascular Surgery Weight Gain |
| title | Increasing Donor Body Weight to Prevent Small-for-Size Syndrome in Living Donor Liver Transplantation |
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