Performance of the Prostate Cancer Antigen 3 (PCA3) Gene and Prostate-Specific Antigen in Prescreened Men: Exploring the Value of PCA3 for a First-line Diagnostic Test
Abstract Background The performance characteristics of serum prostate-specific antigen (PSA) as a diagnostic test for prostate cancer (PCa) are poor. The performance of the PCa antigen 3 (PCA3) gene as a primary diagnostic is unknown. Objective Assess the value of PCA3 as a first-line diagnostic tes...
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| Veröffentlicht in: | European urology 2010-10, Vol.58 (4), p.475-481 |
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| creator | Roobol, Monique J Schröder, Fritz H van Leeuwen, Pim Wolters, Tineke van den Bergh, Roderick C.N van Leenders, Geert J.L.H Hessels, Daphne |
| description | Abstract Background The performance characteristics of serum prostate-specific antigen (PSA) as a diagnostic test for prostate cancer (PCa) are poor. The performance of the PCa antigen 3 (PCA3) gene as a primary diagnostic is unknown. Objective Assess the value of PCA3 as a first-line diagnostic test. Design, setting and participants Participants included men aged 63–75 who were invited for rescreening in the period from September 2007 to February 2009 within the European Randomised Study of Screening for Prostate Cancer, Rotterdam section. Interventions Lateral sextant biopsies were performed if the serum PSA value was ≥3.0 ng/ml and/or the PCA3 score was ≥10. Measurements Measurements included distribution and correlation of PSA value and PCA3 score and their relation to the number of cases and the characteristics of PCa detected. Additional value of PCA3 was included in men with previous negative biopsy and/or PSA |
| doi_str_mv | 10.1016/j.eururo.2010.06.039 |
| format | Article |
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The performance of the PCa antigen 3 (PCA3) gene as a primary diagnostic is unknown. Objective Assess the value of PCA3 as a first-line diagnostic test. Design, setting and participants Participants included men aged 63–75 who were invited for rescreening in the period from September 2007 to February 2009 within the European Randomised Study of Screening for Prostate Cancer, Rotterdam section. Interventions Lateral sextant biopsies were performed if the serum PSA value was ≥3.0 ng/ml and/or the PCA3 score was ≥10. Measurements Measurements included distribution and correlation of PSA value and PCA3 score and their relation to the number of cases and the characteristics of PCa detected. Additional value of PCA3 was included in men with previous negative biopsy and/or PSA <3.0 ng/ml. Results and limitations In 721 men, all biopsied, 122 PCa cases (16.9%) were detected. Correlation between PSA and PCA3 is poor (Spearman rank correlation: ρ = 0.14; p < 0.0001). A PSA ≥3.0 ng/ml misses 64.7% of the total PCa that can be detected with the sextant biopsy technique and 57.9% of serious PCa (T2a or higher and/or Gleason grade ≥4, n = 19), and 68.2% of biopsies could have been avoided; the respective data for PCA3 ≥35 are 32%, 26.3%, and 51.7%. Performance of PCA3 in men with low PSA (area under the curve [AUC]: 0.63) and/or previous negative biopsy (AUC: 0.68) is unclear but has limited reliability due to small numbers. Conclusions PCA3 as a first-line screening test shows improvement of the performance characteristics and identification of serious disease compared with PSA in this prescreened population.</description><identifier>ISSN: 0302-2838</identifier><identifier>EISSN: 1873-7560</identifier><identifier>DOI: 10.1016/j.eururo.2010.06.039</identifier><identifier>PMID: 20637539</identifier><identifier>CODEN: EUURAV</identifier><language>eng</language><publisher>Kidlington: Elsevier</publisher><subject>Aged ; Antigens, Neoplasm - genetics ; Biological and medical sciences ; Gynecology. Andrology. Obstetrics ; Humans ; Male ; Male genital diseases ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Prostate-Specific Antigen - blood ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - genetics ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland ; Urology</subject><ispartof>European urology, 2010-10, Vol.58 (4), p.475-481</ispartof><rights>European Association of Urology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-b53806d8ff2153e2bf17634ce48cc9e7e575a289eccda12767e65d39587534d93</citedby><cites>FETCH-LOGICAL-c457t-b53806d8ff2153e2bf17634ce48cc9e7e575a289eccda12767e65d39587534d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23289416$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20637539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roobol, Monique J</creatorcontrib><creatorcontrib>Schröder, Fritz H</creatorcontrib><creatorcontrib>van Leeuwen, Pim</creatorcontrib><creatorcontrib>Wolters, Tineke</creatorcontrib><creatorcontrib>van den Bergh, Roderick C.N</creatorcontrib><creatorcontrib>van Leenders, Geert J.L.H</creatorcontrib><creatorcontrib>Hessels, Daphne</creatorcontrib><title>Performance of the Prostate Cancer Antigen 3 (PCA3) Gene and Prostate-Specific Antigen in Prescreened Men: Exploring the Value of PCA3 for a First-line Diagnostic Test</title><title>European urology</title><addtitle>Eur Urol</addtitle><description>Abstract Background The performance characteristics of serum prostate-specific antigen (PSA) as a diagnostic test for prostate cancer (PCa) are poor. The performance of the PCa antigen 3 (PCA3) gene as a primary diagnostic is unknown. Objective Assess the value of PCA3 as a first-line diagnostic test. Design, setting and participants Participants included men aged 63–75 who were invited for rescreening in the period from September 2007 to February 2009 within the European Randomised Study of Screening for Prostate Cancer, Rotterdam section. Interventions Lateral sextant biopsies were performed if the serum PSA value was ≥3.0 ng/ml and/or the PCA3 score was ≥10. Measurements Measurements included distribution and correlation of PSA value and PCA3 score and their relation to the number of cases and the characteristics of PCa detected. Additional value of PCA3 was included in men with previous negative biopsy and/or PSA <3.0 ng/ml. Results and limitations In 721 men, all biopsied, 122 PCa cases (16.9%) were detected. Correlation between PSA and PCA3 is poor (Spearman rank correlation: ρ = 0.14; p < 0.0001). A PSA ≥3.0 ng/ml misses 64.7% of the total PCa that can be detected with the sextant biopsy technique and 57.9% of serious PCa (T2a or higher and/or Gleason grade ≥4, n = 19), and 68.2% of biopsies could have been avoided; the respective data for PCA3 ≥35 are 32%, 26.3%, and 51.7%. Performance of PCA3 in men with low PSA (area under the curve [AUC]: 0.63) and/or previous negative biopsy (AUC: 0.68) is unclear but has limited reliability due to small numbers. Conclusions PCA3 as a first-line screening test shows improvement of the performance characteristics and identification of serious disease compared with PSA in this prescreened population.</description><subject>Aged</subject><subject>Antigens, Neoplasm - genetics</subject><subject>Biological and medical sciences</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><subject>Urology</subject><issn>0302-2838</issn><issn>1873-7560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkt2O0zAQhS0EYsvCGyDkGwRcpPgnthMukKqyuyAtotIu3FquMykuqVPsBLFPxGsy2ZZyZcn-5sz4nCHkOWdzzrh-u53DmMbUzwXDK6bnTNYPyIxXRhZGafaQzJhkohCVrM7Ik5y3jDGpavmYnAmmpVGynpE_K0htn3YueqB9S4fvQFepz4MbgC6n20QXcQgbiFTS16vlQr6hVxCButicyOJmDz60wZ_YEPERsk-AbEM_Q3xHL37vuz6FuLnv8s11433LSZPiDNTRy5DyUHQB5T8Et4mojpq3kIen5FHrugzPjuc5-Xp5cbv8WFx_ufq0XFwXvlRmKNZKVkw3VdsKriSIdcuNlqWHsvK-BgPKKCeqGrxvHBdGG9CqkbWq0I6yqeU5eXXQ3af-54iN7S5kD13nIvRjtkaVDB0VDMnyQHo0ISdo7T6FnUt3ljM7JWS39pCQnRKyTFtMCMteHBuM6x00p6J_kSDw8gi47F3XJgwh5P-cxPFLrpF7f-AA7fgVIFmPxgUs-QF3kLf9mCI6ZbnNwjJ7My3DtAsc10Az_MBfsWqvvA</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Roobol, Monique J</creator><creator>Schröder, Fritz H</creator><creator>van Leeuwen, Pim</creator><creator>Wolters, Tineke</creator><creator>van den Bergh, Roderick C.N</creator><creator>van Leenders, Geert J.L.H</creator><creator>Hessels, Daphne</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101001</creationdate><title>Performance of the Prostate Cancer Antigen 3 (PCA3) Gene and Prostate-Specific Antigen in Prescreened Men: Exploring the Value of PCA3 for a First-line Diagnostic Test</title><author>Roobol, Monique J ; Schröder, Fritz H ; van Leeuwen, Pim ; Wolters, Tineke ; van den Bergh, Roderick C.N ; van Leenders, Geert J.L.H ; Hessels, Daphne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-b53806d8ff2153e2bf17634ce48cc9e7e575a289eccda12767e65d39587534d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Antigens, Neoplasm - genetics</topic><topic>Biological and medical sciences</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roobol, Monique J</creatorcontrib><creatorcontrib>Schröder, Fritz H</creatorcontrib><creatorcontrib>van Leeuwen, Pim</creatorcontrib><creatorcontrib>Wolters, Tineke</creatorcontrib><creatorcontrib>van den Bergh, Roderick C.N</creatorcontrib><creatorcontrib>van Leenders, Geert J.L.H</creatorcontrib><creatorcontrib>Hessels, Daphne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roobol, Monique J</au><au>Schröder, Fritz H</au><au>van Leeuwen, Pim</au><au>Wolters, Tineke</au><au>van den Bergh, Roderick C.N</au><au>van Leenders, Geert J.L.H</au><au>Hessels, Daphne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Performance of the Prostate Cancer Antigen 3 (PCA3) Gene and Prostate-Specific Antigen in Prescreened Men: Exploring the Value of PCA3 for a First-line Diagnostic Test</atitle><jtitle>European urology</jtitle><addtitle>Eur Urol</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>58</volume><issue>4</issue><spage>475</spage><epage>481</epage><pages>475-481</pages><issn>0302-2838</issn><eissn>1873-7560</eissn><coden>EUURAV</coden><abstract>Abstract Background The performance characteristics of serum prostate-specific antigen (PSA) as a diagnostic test for prostate cancer (PCa) are poor. The performance of the PCa antigen 3 (PCA3) gene as a primary diagnostic is unknown. Objective Assess the value of PCA3 as a first-line diagnostic test. Design, setting and participants Participants included men aged 63–75 who were invited for rescreening in the period from September 2007 to February 2009 within the European Randomised Study of Screening for Prostate Cancer, Rotterdam section. Interventions Lateral sextant biopsies were performed if the serum PSA value was ≥3.0 ng/ml and/or the PCA3 score was ≥10. Measurements Measurements included distribution and correlation of PSA value and PCA3 score and their relation to the number of cases and the characteristics of PCa detected. Additional value of PCA3 was included in men with previous negative biopsy and/or PSA <3.0 ng/ml. Results and limitations In 721 men, all biopsied, 122 PCa cases (16.9%) were detected. Correlation between PSA and PCA3 is poor (Spearman rank correlation: ρ = 0.14; p < 0.0001). A PSA ≥3.0 ng/ml misses 64.7% of the total PCa that can be detected with the sextant biopsy technique and 57.9% of serious PCa (T2a or higher and/or Gleason grade ≥4, n = 19), and 68.2% of biopsies could have been avoided; the respective data for PCA3 ≥35 are 32%, 26.3%, and 51.7%. Performance of PCA3 in men with low PSA (area under the curve [AUC]: 0.63) and/or previous negative biopsy (AUC: 0.68) is unclear but has limited reliability due to small numbers. Conclusions PCA3 as a first-line screening test shows improvement of the performance characteristics and identification of serious disease compared with PSA in this prescreened population.</abstract><cop>Kidlington</cop><pub>Elsevier</pub><pmid>20637539</pmid><doi>10.1016/j.eururo.2010.06.039</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Antigens, Neoplasm - genetics Biological and medical sciences Gynecology. Andrology. Obstetrics Humans Male Male genital diseases Medical sciences Middle Aged Nephrology. Urinary tract diseases Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - diagnosis Prostatic Neoplasms - genetics Tumors Tumors of the urinary system Urinary tract. Prostate gland Urology |
| title | Performance of the Prostate Cancer Antigen 3 (PCA3) Gene and Prostate-Specific Antigen in Prescreened Men: Exploring the Value of PCA3 for a First-line Diagnostic Test |
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