Utilisation of atypical antipsychotic drugs in institutionalised elderly persons and prevalence of metabolic alterations
Describe and evaluate atypical antipsychotics utilisation on the institutionalized elderly population of the Valencian Community and prevalence of associated metabolic alterations. Multicentre transversal descriptive study on medication utilisation and prevalence case-control of alterations of glyca...
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| Veröffentlicht in: | Farmacia hospitalaria 2010-05, Vol.34 (3), p.139-147 |
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| creator | Martínez Romero, G Peris Martí, J F Gomar Fayos, J Navarro Gosalbez, M Quintana Vargas, I Muelas Tirado, J |
| description | Describe and evaluate atypical antipsychotics utilisation on the institutionalized elderly population of the Valencian Community and prevalence of associated metabolic alterations.
Multicentre transversal descriptive study on medication utilisation and prevalence case-control of alterations of glycaemia, cholesterol and triglycerides. The statistical analysis of metabolic alterations is performed from the difference in prevalence and its statistical signification between the control group and the study group.
681 patients were included (study group, 344; control group, 337) from 20 social-health-care centres. 18.5% of the institutionalised patients are being treated with atypical antipsychotics. The most frequent diagnoses are: behavioural alterations associated with dementia (63.6%) and schizophrenia (18.4%). Risperidone is the most frequently used antipsychotic (66.0%). For all the drugs in general the doses used adjust to those recommended for elderly patients. The prevalence of alterations in glycaemia, cholesterol and triglycerides metabolism in the group under study is 23.96%, 34.83%, and 26.29%, respectively, with no statistically significant differences against the control group. The analysis by type of drug did not show significant differences.
The results obtained show that utilisation of atypical antipsychotics in elderly patients complies with the established general recommendations. The doses used in elderly patients with behavioural alterations associated with dementia, mostly treated with risperidone, do not have a significant impact over prevalence increase of metabolic alterations. |
| doi_str_mv | 10.1016/j.farma.2009.10.010 |
| format | Article |
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Multicentre transversal descriptive study on medication utilisation and prevalence case-control of alterations of glycaemia, cholesterol and triglycerides. The statistical analysis of metabolic alterations is performed from the difference in prevalence and its statistical signification between the control group and the study group.
681 patients were included (study group, 344; control group, 337) from 20 social-health-care centres. 18.5% of the institutionalised patients are being treated with atypical antipsychotics. The most frequent diagnoses are: behavioural alterations associated with dementia (63.6%) and schizophrenia (18.4%). Risperidone is the most frequently used antipsychotic (66.0%). For all the drugs in general the doses used adjust to those recommended for elderly patients. The prevalence of alterations in glycaemia, cholesterol and triglycerides metabolism in the group under study is 23.96%, 34.83%, and 26.29%, respectively, with no statistically significant differences against the control group. The analysis by type of drug did not show significant differences.
The results obtained show that utilisation of atypical antipsychotics in elderly patients complies with the established general recommendations. The doses used in elderly patients with behavioural alterations associated with dementia, mostly treated with risperidone, do not have a significant impact over prevalence increase of metabolic alterations.</description><identifier>ISSN: 1130-6343</identifier><identifier>DOI: 10.1016/j.farma.2009.10.010</identifier><identifier>PMID: 20434929</identifier><language>spa</language><publisher>Spain</publisher><subject>Aged ; Aged, 80 and over ; Antipsychotic Agents - adverse effects ; Antipsychotic Agents - therapeutic use ; Case-Control Studies ; Comorbidity ; Cross-Sectional Studies ; Dementia - epidemiology ; Dementia - psychology ; Dose-Response Relationship, Drug ; Female ; Glucose Intolerance - chemically induced ; Glucose Intolerance - epidemiology ; Humans ; Hypercholesterolemia - chemically induced ; Hypercholesterolemia - epidemiology ; Hypertriglyceridemia - chemically induced ; Hypertriglyceridemia - epidemiology ; Institutionalization ; Male ; Mental Disorders - drug therapy ; Mental Disorders - epidemiology ; Mental Disorders - etiology ; Middle Aged ; Polypharmacy ; Prevalence ; Risperidone - adverse effects ; Risperidone - therapeutic use ; Schizophrenia - drug therapy ; Schizophrenia - epidemiology ; Spain - epidemiology</subject><ispartof>Farmacia hospitalaria, 2010-05, Vol.34 (3), p.139-147</ispartof><rights>Copyright © 2008 SEFH. Published by Elsevier Espana. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20434929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martínez Romero, G</creatorcontrib><creatorcontrib>Peris Martí, J F</creatorcontrib><creatorcontrib>Gomar Fayos, J</creatorcontrib><creatorcontrib>Navarro Gosalbez, M</creatorcontrib><creatorcontrib>Quintana Vargas, I</creatorcontrib><creatorcontrib>Muelas Tirado, J</creatorcontrib><title>Utilisation of atypical antipsychotic drugs in institutionalised elderly persons and prevalence of metabolic alterations</title><title>Farmacia hospitalaria</title><addtitle>Farm Hosp</addtitle><description>Describe and evaluate atypical antipsychotics utilisation on the institutionalized elderly population of the Valencian Community and prevalence of associated metabolic alterations.
Multicentre transversal descriptive study on medication utilisation and prevalence case-control of alterations of glycaemia, cholesterol and triglycerides. The statistical analysis of metabolic alterations is performed from the difference in prevalence and its statistical signification between the control group and the study group.
681 patients were included (study group, 344; control group, 337) from 20 social-health-care centres. 18.5% of the institutionalised patients are being treated with atypical antipsychotics. The most frequent diagnoses are: behavioural alterations associated with dementia (63.6%) and schizophrenia (18.4%). Risperidone is the most frequently used antipsychotic (66.0%). For all the drugs in general the doses used adjust to those recommended for elderly patients. The prevalence of alterations in glycaemia, cholesterol and triglycerides metabolism in the group under study is 23.96%, 34.83%, and 26.29%, respectively, with no statistically significant differences against the control group. The analysis by type of drug did not show significant differences.
The results obtained show that utilisation of atypical antipsychotics in elderly patients complies with the established general recommendations. The doses used in elderly patients with behavioural alterations associated with dementia, mostly treated with risperidone, do not have a significant impact over prevalence increase of metabolic alterations.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antipsychotic Agents - adverse effects</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Case-Control Studies</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Dementia - epidemiology</subject><subject>Dementia - psychology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Glucose Intolerance - chemically induced</subject><subject>Glucose Intolerance - epidemiology</subject><subject>Humans</subject><subject>Hypercholesterolemia - chemically induced</subject><subject>Hypercholesterolemia - epidemiology</subject><subject>Hypertriglyceridemia - chemically induced</subject><subject>Hypertriglyceridemia - epidemiology</subject><subject>Institutionalization</subject><subject>Male</subject><subject>Mental Disorders - drug therapy</subject><subject>Mental Disorders - epidemiology</subject><subject>Mental Disorders - etiology</subject><subject>Middle Aged</subject><subject>Polypharmacy</subject><subject>Prevalence</subject><subject>Risperidone - adverse effects</subject><subject>Risperidone - therapeutic use</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - epidemiology</subject><subject>Spain - epidemiology</subject><issn>1130-6343</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtKxDAUhrNQnHH0CQTJzlVrbr1kKYM3GHAzrkuanGqGtKlJKvbt7XiBAwcO3_8d-BG6oiSnhJa3h7xToVc5I0Qul5xQcoLWlHKSlVzwFTqP8UBIwSpGz9CKEcGFZHKNvl6TdTaqZP2AfYdVmkerlcNqSHaMs373yWpswvQWsR2Wicmm6YirJQcGgzMQ3IxHCNEPcQkaPAb4VA4GDUdnD0m13i0a5RKEn1_xAp12ykW4_NsbtH-432-fst3L4_P2bpeNRSEzU8tWllQSKCsNHTe0JEwp2lWiqA01IKBrtTbGQF2wUrS0bklHja6JpKBrvkE3v9ox-I8JYmp6GzU4pwbwU2yqQhBWciYW8vqPnNoeTDMG26swN_9d8W8jrW-A</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>Martínez Romero, G</creator><creator>Peris Martí, J F</creator><creator>Gomar Fayos, J</creator><creator>Navarro Gosalbez, M</creator><creator>Quintana Vargas, I</creator><creator>Muelas Tirado, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201005</creationdate><title>Utilisation of atypical antipsychotic drugs in institutionalised elderly persons and prevalence of metabolic alterations</title><author>Martínez Romero, G ; Peris Martí, J F ; Gomar Fayos, J ; Navarro Gosalbez, M ; Quintana Vargas, I ; Muelas Tirado, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p559-d89b96190e67cef3d1602aa1f7458d1de4efbccddde85264b18b0f1dc8091ec83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antipsychotic Agents - adverse effects</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Case-Control Studies</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Dementia - epidemiology</topic><topic>Dementia - psychology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Glucose Intolerance - chemically induced</topic><topic>Glucose Intolerance - epidemiology</topic><topic>Humans</topic><topic>Hypercholesterolemia - chemically induced</topic><topic>Hypercholesterolemia - epidemiology</topic><topic>Hypertriglyceridemia - chemically induced</topic><topic>Hypertriglyceridemia - epidemiology</topic><topic>Institutionalization</topic><topic>Male</topic><topic>Mental Disorders - drug therapy</topic><topic>Mental Disorders - epidemiology</topic><topic>Mental Disorders - etiology</topic><topic>Middle Aged</topic><topic>Polypharmacy</topic><topic>Prevalence</topic><topic>Risperidone - adverse effects</topic><topic>Risperidone - therapeutic use</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenia - epidemiology</topic><topic>Spain - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martínez Romero, G</creatorcontrib><creatorcontrib>Peris Martí, J F</creatorcontrib><creatorcontrib>Gomar Fayos, J</creatorcontrib><creatorcontrib>Navarro Gosalbez, M</creatorcontrib><creatorcontrib>Quintana Vargas, I</creatorcontrib><creatorcontrib>Muelas Tirado, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Farmacia hospitalaria</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martínez Romero, G</au><au>Peris Martí, J F</au><au>Gomar Fayos, J</au><au>Navarro Gosalbez, M</au><au>Quintana Vargas, I</au><au>Muelas Tirado, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utilisation of atypical antipsychotic drugs in institutionalised elderly persons and prevalence of metabolic alterations</atitle><jtitle>Farmacia hospitalaria</jtitle><addtitle>Farm Hosp</addtitle><date>2010-05</date><risdate>2010</risdate><volume>34</volume><issue>3</issue><spage>139</spage><epage>147</epage><pages>139-147</pages><issn>1130-6343</issn><abstract>Describe and evaluate atypical antipsychotics utilisation on the institutionalized elderly population of the Valencian Community and prevalence of associated metabolic alterations.
Multicentre transversal descriptive study on medication utilisation and prevalence case-control of alterations of glycaemia, cholesterol and triglycerides. The statistical analysis of metabolic alterations is performed from the difference in prevalence and its statistical signification between the control group and the study group.
681 patients were included (study group, 344; control group, 337) from 20 social-health-care centres. 18.5% of the institutionalised patients are being treated with atypical antipsychotics. The most frequent diagnoses are: behavioural alterations associated with dementia (63.6%) and schizophrenia (18.4%). Risperidone is the most frequently used antipsychotic (66.0%). For all the drugs in general the doses used adjust to those recommended for elderly patients. The prevalence of alterations in glycaemia, cholesterol and triglycerides metabolism in the group under study is 23.96%, 34.83%, and 26.29%, respectively, with no statistically significant differences against the control group. The analysis by type of drug did not show significant differences.
The results obtained show that utilisation of atypical antipsychotics in elderly patients complies with the established general recommendations. The doses used in elderly patients with behavioural alterations associated with dementia, mostly treated with risperidone, do not have a significant impact over prevalence increase of metabolic alterations.</abstract><cop>Spain</cop><pmid>20434929</pmid><doi>10.1016/j.farma.2009.10.010</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Case-Control Studies Comorbidity Cross-Sectional Studies Dementia - epidemiology Dementia - psychology Dose-Response Relationship, Drug Female Glucose Intolerance - chemically induced Glucose Intolerance - epidemiology Humans Hypercholesterolemia - chemically induced Hypercholesterolemia - epidemiology Hypertriglyceridemia - chemically induced Hypertriglyceridemia - epidemiology Institutionalization Male Mental Disorders - drug therapy Mental Disorders - epidemiology Mental Disorders - etiology Middle Aged Polypharmacy Prevalence Risperidone - adverse effects Risperidone - therapeutic use Schizophrenia - drug therapy Schizophrenia - epidemiology Spain - epidemiology |
| title | Utilisation of atypical antipsychotic drugs in institutionalised elderly persons and prevalence of metabolic alterations |
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