Evolutionary patterns of non-coding RNAs
A plethora of new functions of non-coding RNAs (ncRNAs) have been discovered in past few years. In fact, RNA is emerging as the central player in cellular regulation, taking on active roles in multiple regulatory layers from transcription, RNA maturation, and RNA modification to translational regula...
Gespeichert in:
| Veröffentlicht in: | Theory in biosciences = Theorie in den Biowissenschaften 2005-04, Vol.123 (4), p.301-369 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 369 |
|---|---|
| container_issue | 4 |
| container_start_page | 301 |
| container_title | Theory in biosciences = Theorie in den Biowissenschaften |
| container_volume | 123 |
| creator | Bompfünewerer, Athanasius F. Flamm, Christoph Fried, Claudia Fritzsch, Guido Hofacker, Ivo L. Lehmann, Jörg Missal, Kristin Mosig, Axel Müller, Bettina Prohaska, Sonja J. Stadler, Bärbel M.R. Stadler, Peter F. Tanzer, Andrea Washietl, Stefan Witwer, Christina |
| description | A plethora of new functions of non-coding RNAs (ncRNAs) have been discovered in past few years. In fact, RNA is emerging as
the central player in cellular regulation, taking on active roles in multiple regulatory layers from transcription, RNA maturation, and RNA modification to translational regulation. Nevertheless, very little is known about the evolution of this “Modern RNA World” and its components. In this contribution, we attempt to provide at least a cursory overview of the diversity of ncRNAs and functional RNA motifs in non-translated regions of regular messenger RNAs (mRNAs) with an emphasis on evolutionary questions. This survey is complemented by an in-depth analysis of examples from different classes of RNAs focusing mostly on their evolution in the vertebrate lineage. We present a survey of Y RNA genes in vertebrates and study the molecular evolution of the U7 snRNA, the snoRNAs E1/U17, E2, and E3, the Y RNA family, the
let-7 microRNA (miRNA) family, and the mRNA-like
evf-1 gene. We furthermore discuss the statistical distribution of miRNAs in metazoans, which suggests an explosive increase in the miRNA repertoire in vertebrates. The analysis of the transcription of ncRNAs suggests that small RNAs in general are genetically mobile in the sense that their association with a hostgene (e.g. when transcribed from introns of a mRNA) can change on evolutionary time scales. The
let-7 family demonstrates, that even the mode of transcription (as intron or as exon) can change among paralogous ncRNA. |
| doi_str_mv | 10.1016/j.thbio.2005.01.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_754025870</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1431761305000157</els_id><sourcerecordid>754025870</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-b24255760ecd308e61a89d51c8e22b0d4beda9a9525962979e62218726b46be23</originalsourceid><addsrcrecordid>eNp9kE1LwzAYx4Mobk4_gSAFD3ppTdImbQ4expgvMBREz6FNnmlKl8ykHfjtzdxA8ODpeQ6___PyQ-ic4Ixgwm_arP9ojMsoxizDJMOYHqAx4YSkJcvxYeyLPPac5CN0EkIbAVIKfoxGpKKYViUeo-v5xnVDb5yt_VeyrvsevA2JWybW2VQ5bex78vI0DafoaFl3Ac72dYLe7uavs4d08Xz_OJsuUhWX9WlDC8pYyTEoneMKOKkroRlRFVDaYF00oGtRC0aZ4FSUAjilpCopbwreAM0n6Go3d-3d5wChlysTFHRdbcENQZaswJTF2yN5-Yds3eBtPE7SvIpvC0ZYpPIdpbwLwcNSrr1ZxWclwXLrUbbyx6PcepSYyKgppi72s4dmBfo3sxcXgdsdANHFxoCXQRmwCrTxoHqpnfl3wTcWV4GB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2387619515</pqid></control><display><type>article</type><title>Evolutionary patterns of non-coding RNAs</title><source>SpringerLink Journals</source><creator>Bompfünewerer, Athanasius F. ; Flamm, Christoph ; Fried, Claudia ; Fritzsch, Guido ; Hofacker, Ivo L. ; Lehmann, Jörg ; Missal, Kristin ; Mosig, Axel ; Müller, Bettina ; Prohaska, Sonja J. ; Stadler, Bärbel M.R. ; Stadler, Peter F. ; Tanzer, Andrea ; Washietl, Stefan ; Witwer, Christina</creator><creatorcontrib>Bompfünewerer, Athanasius F. ; Flamm, Christoph ; Fried, Claudia ; Fritzsch, Guido ; Hofacker, Ivo L. ; Lehmann, Jörg ; Missal, Kristin ; Mosig, Axel ; Müller, Bettina ; Prohaska, Sonja J. ; Stadler, Bärbel M.R. ; Stadler, Peter F. ; Tanzer, Andrea ; Washietl, Stefan ; Witwer, Christina</creatorcontrib><description>A plethora of new functions of non-coding RNAs (ncRNAs) have been discovered in past few years. In fact, RNA is emerging as
the central player in cellular regulation, taking on active roles in multiple regulatory layers from transcription, RNA maturation, and RNA modification to translational regulation. Nevertheless, very little is known about the evolution of this “Modern RNA World” and its components. In this contribution, we attempt to provide at least a cursory overview of the diversity of ncRNAs and functional RNA motifs in non-translated regions of regular messenger RNAs (mRNAs) with an emphasis on evolutionary questions. This survey is complemented by an in-depth analysis of examples from different classes of RNAs focusing mostly on their evolution in the vertebrate lineage. We present a survey of Y RNA genes in vertebrates and study the molecular evolution of the U7 snRNA, the snoRNAs E1/U17, E2, and E3, the Y RNA family, the
let-7 microRNA (miRNA) family, and the mRNA-like
evf-1 gene. We furthermore discuss the statistical distribution of miRNAs in metazoans, which suggests an explosive increase in the miRNA repertoire in vertebrates. The analysis of the transcription of ncRNAs suggests that small RNAs in general are genetically mobile in the sense that their association with a hostgene (e.g. when transcribed from introns of a mRNA) can change on evolutionary time scales. The
let-7 family demonstrates, that even the mode of transcription (as intron or as exon) can change among paralogous ncRNA.</description><identifier>ISSN: 1431-7613</identifier><identifier>EISSN: 1611-7530</identifier><identifier>DOI: 10.1016/j.thbio.2005.01.002</identifier><identifier>PMID: 18202870</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Biology ; Evolution ; Evolutionary genetics ; gRNA ; Introns ; MicroRNAs ; miRNA ; Molecular evolution ; mRNA ; Non-coding RNA ; RNA editing ; RNA modification ; rRNA ; snoRNA ; snRNA ; Transcription ; UTR ; Vault RNA ; Vertebrates ; Y-RNA</subject><ispartof>Theory in biosciences = Theorie in den Biowissenschaften, 2005-04, Vol.123 (4), p.301-369</ispartof><rights>2005 Elsevier GmbH</rights><rights>Elsevier GmbH 2005.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-b24255760ecd308e61a89d51c8e22b0d4beda9a9525962979e62218726b46be23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18202870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bompfünewerer, Athanasius F.</creatorcontrib><creatorcontrib>Flamm, Christoph</creatorcontrib><creatorcontrib>Fried, Claudia</creatorcontrib><creatorcontrib>Fritzsch, Guido</creatorcontrib><creatorcontrib>Hofacker, Ivo L.</creatorcontrib><creatorcontrib>Lehmann, Jörg</creatorcontrib><creatorcontrib>Missal, Kristin</creatorcontrib><creatorcontrib>Mosig, Axel</creatorcontrib><creatorcontrib>Müller, Bettina</creatorcontrib><creatorcontrib>Prohaska, Sonja J.</creatorcontrib><creatorcontrib>Stadler, Bärbel M.R.</creatorcontrib><creatorcontrib>Stadler, Peter F.</creatorcontrib><creatorcontrib>Tanzer, Andrea</creatorcontrib><creatorcontrib>Washietl, Stefan</creatorcontrib><creatorcontrib>Witwer, Christina</creatorcontrib><title>Evolutionary patterns of non-coding RNAs</title><title>Theory in biosciences = Theorie in den Biowissenschaften</title><addtitle>Theory Biosci</addtitle><description>A plethora of new functions of non-coding RNAs (ncRNAs) have been discovered in past few years. In fact, RNA is emerging as
the central player in cellular regulation, taking on active roles in multiple regulatory layers from transcription, RNA maturation, and RNA modification to translational regulation. Nevertheless, very little is known about the evolution of this “Modern RNA World” and its components. In this contribution, we attempt to provide at least a cursory overview of the diversity of ncRNAs and functional RNA motifs in non-translated regions of regular messenger RNAs (mRNAs) with an emphasis on evolutionary questions. This survey is complemented by an in-depth analysis of examples from different classes of RNAs focusing mostly on their evolution in the vertebrate lineage. We present a survey of Y RNA genes in vertebrates and study the molecular evolution of the U7 snRNA, the snoRNAs E1/U17, E2, and E3, the Y RNA family, the
let-7 microRNA (miRNA) family, and the mRNA-like
evf-1 gene. We furthermore discuss the statistical distribution of miRNAs in metazoans, which suggests an explosive increase in the miRNA repertoire in vertebrates. The analysis of the transcription of ncRNAs suggests that small RNAs in general are genetically mobile in the sense that their association with a hostgene (e.g. when transcribed from introns of a mRNA) can change on evolutionary time scales. The
let-7 family demonstrates, that even the mode of transcription (as intron or as exon) can change among paralogous ncRNA.</description><subject>Biology</subject><subject>Evolution</subject><subject>Evolutionary genetics</subject><subject>gRNA</subject><subject>Introns</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Molecular evolution</subject><subject>mRNA</subject><subject>Non-coding RNA</subject><subject>RNA editing</subject><subject>RNA modification</subject><subject>rRNA</subject><subject>snoRNA</subject><subject>snRNA</subject><subject>Transcription</subject><subject>UTR</subject><subject>Vault RNA</subject><subject>Vertebrates</subject><subject>Y-RNA</subject><issn>1431-7613</issn><issn>1611-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LwzAYx4Mobk4_gSAFD3ppTdImbQ4expgvMBREz6FNnmlKl8ykHfjtzdxA8ODpeQ6___PyQ-ic4Ixgwm_arP9ojMsoxizDJMOYHqAx4YSkJcvxYeyLPPac5CN0EkIbAVIKfoxGpKKYViUeo-v5xnVDb5yt_VeyrvsevA2JWybW2VQ5bex78vI0DafoaFl3Ac72dYLe7uavs4d08Xz_OJsuUhWX9WlDC8pYyTEoneMKOKkroRlRFVDaYF00oGtRC0aZ4FSUAjilpCopbwreAM0n6Go3d-3d5wChlysTFHRdbcENQZaswJTF2yN5-Yds3eBtPE7SvIpvC0ZYpPIdpbwLwcNSrr1ZxWclwXLrUbbyx6PcepSYyKgppi72s4dmBfo3sxcXgdsdANHFxoCXQRmwCrTxoHqpnfl3wTcWV4GB</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Bompfünewerer, Athanasius F.</creator><creator>Flamm, Christoph</creator><creator>Fried, Claudia</creator><creator>Fritzsch, Guido</creator><creator>Hofacker, Ivo L.</creator><creator>Lehmann, Jörg</creator><creator>Missal, Kristin</creator><creator>Mosig, Axel</creator><creator>Müller, Bettina</creator><creator>Prohaska, Sonja J.</creator><creator>Stadler, Bärbel M.R.</creator><creator>Stadler, Peter F.</creator><creator>Tanzer, Andrea</creator><creator>Washietl, Stefan</creator><creator>Witwer, Christina</creator><general>Elsevier GmbH</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Evolutionary patterns of non-coding RNAs</title><author>Bompfünewerer, Athanasius F. ; Flamm, Christoph ; Fried, Claudia ; Fritzsch, Guido ; Hofacker, Ivo L. ; Lehmann, Jörg ; Missal, Kristin ; Mosig, Axel ; Müller, Bettina ; Prohaska, Sonja J. ; Stadler, Bärbel M.R. ; Stadler, Peter F. ; Tanzer, Andrea ; Washietl, Stefan ; Witwer, Christina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-b24255760ecd308e61a89d51c8e22b0d4beda9a9525962979e62218726b46be23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biology</topic><topic>Evolution</topic><topic>Evolutionary genetics</topic><topic>gRNA</topic><topic>Introns</topic><topic>MicroRNAs</topic><topic>miRNA</topic><topic>Molecular evolution</topic><topic>mRNA</topic><topic>Non-coding RNA</topic><topic>RNA editing</topic><topic>RNA modification</topic><topic>rRNA</topic><topic>snoRNA</topic><topic>snRNA</topic><topic>Transcription</topic><topic>UTR</topic><topic>Vault RNA</topic><topic>Vertebrates</topic><topic>Y-RNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bompfünewerer, Athanasius F.</creatorcontrib><creatorcontrib>Flamm, Christoph</creatorcontrib><creatorcontrib>Fried, Claudia</creatorcontrib><creatorcontrib>Fritzsch, Guido</creatorcontrib><creatorcontrib>Hofacker, Ivo L.</creatorcontrib><creatorcontrib>Lehmann, Jörg</creatorcontrib><creatorcontrib>Missal, Kristin</creatorcontrib><creatorcontrib>Mosig, Axel</creatorcontrib><creatorcontrib>Müller, Bettina</creatorcontrib><creatorcontrib>Prohaska, Sonja J.</creatorcontrib><creatorcontrib>Stadler, Bärbel M.R.</creatorcontrib><creatorcontrib>Stadler, Peter F.</creatorcontrib><creatorcontrib>Tanzer, Andrea</creatorcontrib><creatorcontrib>Washietl, Stefan</creatorcontrib><creatorcontrib>Witwer, Christina</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Theory in biosciences = Theorie in den Biowissenschaften</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bompfünewerer, Athanasius F.</au><au>Flamm, Christoph</au><au>Fried, Claudia</au><au>Fritzsch, Guido</au><au>Hofacker, Ivo L.</au><au>Lehmann, Jörg</au><au>Missal, Kristin</au><au>Mosig, Axel</au><au>Müller, Bettina</au><au>Prohaska, Sonja J.</au><au>Stadler, Bärbel M.R.</au><au>Stadler, Peter F.</au><au>Tanzer, Andrea</au><au>Washietl, Stefan</au><au>Witwer, Christina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evolutionary patterns of non-coding RNAs</atitle><jtitle>Theory in biosciences = Theorie in den Biowissenschaften</jtitle><addtitle>Theory Biosci</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>123</volume><issue>4</issue><spage>301</spage><epage>369</epage><pages>301-369</pages><issn>1431-7613</issn><eissn>1611-7530</eissn><abstract>A plethora of new functions of non-coding RNAs (ncRNAs) have been discovered in past few years. In fact, RNA is emerging as
the central player in cellular regulation, taking on active roles in multiple regulatory layers from transcription, RNA maturation, and RNA modification to translational regulation. Nevertheless, very little is known about the evolution of this “Modern RNA World” and its components. In this contribution, we attempt to provide at least a cursory overview of the diversity of ncRNAs and functional RNA motifs in non-translated regions of regular messenger RNAs (mRNAs) with an emphasis on evolutionary questions. This survey is complemented by an in-depth analysis of examples from different classes of RNAs focusing mostly on their evolution in the vertebrate lineage. We present a survey of Y RNA genes in vertebrates and study the molecular evolution of the U7 snRNA, the snoRNAs E1/U17, E2, and E3, the Y RNA family, the
let-7 microRNA (miRNA) family, and the mRNA-like
evf-1 gene. We furthermore discuss the statistical distribution of miRNAs in metazoans, which suggests an explosive increase in the miRNA repertoire in vertebrates. The analysis of the transcription of ncRNAs suggests that small RNAs in general are genetically mobile in the sense that their association with a hostgene (e.g. when transcribed from introns of a mRNA) can change on evolutionary time scales. The
let-7 family demonstrates, that even the mode of transcription (as intron or as exon) can change among paralogous ncRNA.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>18202870</pmid><doi>10.1016/j.thbio.2005.01.002</doi><tpages>69</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1431-7613 |
| ispartof | Theory in biosciences = Theorie in den Biowissenschaften, 2005-04, Vol.123 (4), p.301-369 |
| issn | 1431-7613 1611-7530 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_754025870 |
| source | SpringerLink Journals |
| subjects | Biology Evolution Evolutionary genetics gRNA Introns MicroRNAs miRNA Molecular evolution mRNA Non-coding RNA RNA editing RNA modification rRNA snoRNA snRNA Transcription UTR Vault RNA Vertebrates Y-RNA |
| title | Evolutionary patterns of non-coding RNAs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T08%3A17%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evolutionary%20patterns%20of%20non-coding%20RNAs&rft.jtitle=Theory%20in%20biosciences%20=%20Theorie%20in%20den%20Biowissenschaften&rft.au=Bompf%C3%BCnewerer,%20Athanasius%20F.&rft.date=2005-04-01&rft.volume=123&rft.issue=4&rft.spage=301&rft.epage=369&rft.pages=301-369&rft.issn=1431-7613&rft.eissn=1611-7530&rft_id=info:doi/10.1016/j.thbio.2005.01.002&rft_dat=%3Cproquest_cross%3E754025870%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2387619515&rft_id=info:pmid/18202870&rft_els_id=S1431761305000157&rfr_iscdi=true |