Inhibitory Effects of Nitrative Stress on the Sulfation of 17β-Estradiol and 4-Methoxyestradiol by Human MCF 10A Mammary Epithelial Cells

Prolonged exposure to high level of estrogen is a known risk factor for breast carcinogenesis. It has been suggested recently that nitrative stress may be an etiologic factor for breast carcinogenesis. Since sulfation plays a major role in the homeostasis of estrogens and their metabolites, we attem...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2010/09/01, Vol.33(9), pp.1633-1637
Hauptverfasser:	Hui, Ying, Yasuda, Tomoko, Yasuda, Shin, Liu, Ming-Yih, Sakakibara, Yoichi, Suiko, Masahito, Wall, Katherine Ann, Liu, Ming-Cheh
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-estradiol 4-methoxyestradiol Cell Line Dose-Response Relationship, Drug Epithelial Cells - drug effects Epithelial Cells - enzymology Estradiol - analogs & derivatives Estradiol - metabolism Humans Mammary Glands, Human - drug effects Mammary Glands, Human - enzymology nitrative stress Nitric Oxide Donors - pharmacology Nitro Compounds - pharmacology Oxidative Stress - drug effects Oxidative Stress - physiology sulfation sulfotransferase isoform 1E1 Sulfotransferases - antagonists & inhibitors Sulfotransferases - metabolism
Online-Zugang:	Volltext
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