Association between coronary flow reserve, left ventricular systolic function, and myocardial viability in acute myocardial infarction
To investigate the relationships between coronary flow reserve (CFR), left ventricular (LV) systolic function, and myocardial viability in patients with acute myocardial infarction (AMI). In 149 patients with a first AMI, we estimated CFR non-invasively and assessed LV systolic function with low-dos...
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| Veröffentlicht in: | European journal of echocardiography 2010-09, Vol.11 (8), p.665-670 |
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| creator | Løgstrup, Brian Bridal Høfsten, Dan E Christophersen, Thomas B Møller, Jacob E Bøtker, Hans E Pellikka, Patricia A Egstrup, Kenneth |
| description | To investigate the relationships between coronary flow reserve (CFR), left ventricular (LV) systolic function, and myocardial viability in patients with acute myocardial infarction (AMI).
In 149 patients with a first AMI, we estimated CFR non-invasively and assessed LV systolic function with low-dose dobutamine Doppler echocardiography (LDDE), which also identified viability. Resting echocardiographic variables did not differ between patients with preserved (54.4%) and low CFR (45.6%). During LDDE, longitudinal LV function was decreased [9.5 cm/s (8;11.3) vs. 10.6 cm/s (8.5;12.5), P = 0.04] and end-systolic volume increased [49.5 mL (38;66) vs. 42 (31;61), P = 0.04] in patients with low compared with preserved CFR. Among 87 (58%) patients with resting wall motion abnormalities, 28 met the criteria for viability. One of 53 (2%) met the criteria for viability in patients with CFR < or =2 compared with 27 of 34 (79%) with CFR > 2, P < 0.0001.
Resting echocardiographic parameters were similar in patient groups. During LDDE, patients with reduced CFR had increased LV size and compromised longitudinal function of LV and were less likely to have evidence of myocardial viability. |
| doi_str_mv | 10.1093/ejechocard/jeq037 |
| format | Article |
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In 149 patients with a first AMI, we estimated CFR non-invasively and assessed LV systolic function with low-dose dobutamine Doppler echocardiography (LDDE), which also identified viability. Resting echocardiographic variables did not differ between patients with preserved (54.4%) and low CFR (45.6%). During LDDE, longitudinal LV function was decreased [9.5 cm/s (8;11.3) vs. 10.6 cm/s (8.5;12.5), P = 0.04] and end-systolic volume increased [49.5 mL (38;66) vs. 42 (31;61), P = 0.04] in patients with low compared with preserved CFR. Among 87 (58%) patients with resting wall motion abnormalities, 28 met the criteria for viability. One of 53 (2%) met the criteria for viability in patients with CFR < or =2 compared with 27 of 34 (79%) with CFR > 2, P < 0.0001.
Resting echocardiographic parameters were similar in patient groups. During LDDE, patients with reduced CFR had increased LV size and compromised longitudinal function of LV and were less likely to have evidence of myocardial viability.</description><identifier>ISSN: 1525-2167</identifier><identifier>EISSN: 1532-2114</identifier><identifier>DOI: 10.1093/ejechocard/jeq037</identifier><identifier>PMID: 20308193</identifier><language>eng</language><publisher>England</publisher><subject>Aged ; Angioplasty, Balloon, Coronary ; Coronary Angiography ; Coronary Circulation - physiology ; Echocardiography, Stress ; Female ; Hemodynamics ; Humans ; Logistic Models ; Male ; Microcirculation ; Middle Aged ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - pathology ; Myocardial Infarction - therapy ; Myocardium ; Statistics as Topic ; Statistics, Nonparametric ; Stroke Volume ; Systole ; Ventricular Function, Left</subject><ispartof>European journal of echocardiography, 2010-09, Vol.11 (8), p.665-670</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-cd2b4e88bf537def578c3bb83b6349b5fb3579dfbc7f48ddc955c9850cf5f293</citedby><cites>FETCH-LOGICAL-c413t-cd2b4e88bf537def578c3bb83b6349b5fb3579dfbc7f48ddc955c9850cf5f293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20308193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Løgstrup, Brian Bridal</creatorcontrib><creatorcontrib>Høfsten, Dan E</creatorcontrib><creatorcontrib>Christophersen, Thomas B</creatorcontrib><creatorcontrib>Møller, Jacob E</creatorcontrib><creatorcontrib>Bøtker, Hans E</creatorcontrib><creatorcontrib>Pellikka, Patricia A</creatorcontrib><creatorcontrib>Egstrup, Kenneth</creatorcontrib><title>Association between coronary flow reserve, left ventricular systolic function, and myocardial viability in acute myocardial infarction</title><title>European journal of echocardiography</title><addtitle>Eur J Echocardiogr</addtitle><description>To investigate the relationships between coronary flow reserve (CFR), left ventricular (LV) systolic function, and myocardial viability in patients with acute myocardial infarction (AMI).
In 149 patients with a first AMI, we estimated CFR non-invasively and assessed LV systolic function with low-dose dobutamine Doppler echocardiography (LDDE), which also identified viability. Resting echocardiographic variables did not differ between patients with preserved (54.4%) and low CFR (45.6%). During LDDE, longitudinal LV function was decreased [9.5 cm/s (8;11.3) vs. 10.6 cm/s (8.5;12.5), P = 0.04] and end-systolic volume increased [49.5 mL (38;66) vs. 42 (31;61), P = 0.04] in patients with low compared with preserved CFR. Among 87 (58%) patients with resting wall motion abnormalities, 28 met the criteria for viability. One of 53 (2%) met the criteria for viability in patients with CFR < or =2 compared with 27 of 34 (79%) with CFR > 2, P < 0.0001.
Resting echocardiographic parameters were similar in patient groups. During LDDE, patients with reduced CFR had increased LV size and compromised longitudinal function of LV and were less likely to have evidence of myocardial viability.</description><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Coronary Angiography</subject><subject>Coronary Circulation - physiology</subject><subject>Echocardiography, Stress</subject><subject>Female</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Microcirculation</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardial Infarction - therapy</subject><subject>Myocardium</subject><subject>Statistics as Topic</subject><subject>Statistics, Nonparametric</subject><subject>Stroke Volume</subject><subject>Systole</subject><subject>Ventricular Function, Left</subject><issn>1525-2167</issn><issn>1532-2114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtKAzEUhoMoVqsP4Eayc2M1mUw6M8si3kBw435IzpxgSpq0SaalL-BzO7XeVueH_8LhI-SCsxvOGnGLc4T3ACp2t3NcMVEdkBMuRTEpOC8Pd7qQg55WI3Ka0pwxPrjlMRkVTLCaN-KEfMxSCmBVtsFTjXmD6CmEGLyKW2pc2NCICeMar6lDk-kafY4WeqciTduUg7NATe9ht3BNle_oYvv1k1WOrq3S1tm8pdZTBX3G_671RsWv4hk5MsolPP--Y_L2cP929zR5eX18vpu9TKDkIk-gK3SJda2NFFWHRlY1CK1roaeibLQ0Wsiq6YyGypR110EjJTS1ZGCkKRoxJlf72WUMqx5Tbhc2ATqnPIY-tZUsWSGqgdKY8H0SYkgpommX0S4GJi1n7Q5--we_3cMfOpff671eYPfb-KEtPgGU-4i7</recordid><startdate>201009</startdate><enddate>201009</enddate><creator>Løgstrup, Brian Bridal</creator><creator>Høfsten, Dan E</creator><creator>Christophersen, Thomas B</creator><creator>Møller, Jacob E</creator><creator>Bøtker, Hans E</creator><creator>Pellikka, Patricia A</creator><creator>Egstrup, Kenneth</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201009</creationdate><title>Association between coronary flow reserve, left ventricular systolic function, and myocardial viability in acute myocardial infarction</title><author>Løgstrup, Brian Bridal ; 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In 149 patients with a first AMI, we estimated CFR non-invasively and assessed LV systolic function with low-dose dobutamine Doppler echocardiography (LDDE), which also identified viability. Resting echocardiographic variables did not differ between patients with preserved (54.4%) and low CFR (45.6%). During LDDE, longitudinal LV function was decreased [9.5 cm/s (8;11.3) vs. 10.6 cm/s (8.5;12.5), P = 0.04] and end-systolic volume increased [49.5 mL (38;66) vs. 42 (31;61), P = 0.04] in patients with low compared with preserved CFR. Among 87 (58%) patients with resting wall motion abnormalities, 28 met the criteria for viability. One of 53 (2%) met the criteria for viability in patients with CFR < or =2 compared with 27 of 34 (79%) with CFR > 2, P < 0.0001.
Resting echocardiographic parameters were similar in patient groups. During LDDE, patients with reduced CFR had increased LV size and compromised longitudinal function of LV and were less likely to have evidence of myocardial viability.</abstract><cop>England</cop><pmid>20308193</pmid><doi>10.1093/ejechocard/jeq037</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Angioplasty, Balloon, Coronary Coronary Angiography Coronary Circulation - physiology Echocardiography, Stress Female Hemodynamics Humans Logistic Models Male Microcirculation Middle Aged Myocardial Infarction - diagnostic imaging Myocardial Infarction - pathology Myocardial Infarction - therapy Myocardium Statistics as Topic Statistics, Nonparametric Stroke Volume Systole Ventricular Function, Left |
| title | Association between coronary flow reserve, left ventricular systolic function, and myocardial viability in acute myocardial infarction |
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