Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy

Ischemic cardiomyopathy is the major cause of heart failure and a significant cause of morbidity and mortality. The degree of left ventricular dysfunction in this setting is often out of proportion to the amount of overtly infarcted tissue, and how decreased delivery of oxygen and nutrients leads to...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2010-09, Vol.122 (10), p.1004-1016
Hauptverfasser:	MOSLEHI, Javid, MINAMISHIMA, Yoji Andrew, JIANRU SHI, NEUBERG, Donna, CHARYTAN, David M, PADERA, Robert F, SIGNORETTI, Sabina, LIAO, Ronglih, KAELIN, William G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - metabolism Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiomyopathy, Dilated - metabolism Cardiomyopathy, Dilated - physiopathology Cell Hypoxia - physiology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fundamental and applied biological sciences. Psychology General aspects Heart Failure - metabolism Heart Failure - physiopathology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-Inducible Factor-Proline Dioxygenases Medical sciences Mice Mice, Inbred C57BL Mice, Mutant Strains Mitochondria - metabolism Myocardial Stunning - metabolism Myocardial Stunning - physiopathology Myocardium - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - enzymology Neovascularization, Physiologic - physiology Phenotype Procollagen-Proline Dioxygenase - genetics Procollagen-Proline Dioxygenase - metabolism Vertebrates: cardiovascular system
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